US4563184A — Synthetic resin wound dressing and method of trea…

Claim 1

Independent Claim 105 words

In combination with a synthetic resin wound dressing of the type wherein a particulate, hydrophilic, water swellable polymer of an acrylate or acrylamide, is combined with an inert, non-toxic, water miscible organic solvent of polyethylene glycol, capable of forming a paste with said polymer, the improvement which comprises, a hydrogen bonding plasticizer of dimethylsulfoxide mixed with the combined polymer and solvent, with said polymer ranging between about 30%-55% by weight of said dressing, with said solvent ranging between about 20%-60% by weight of said dressing, and with said plasticizer being present in a plasticizing amount ranging up to about 20% by weight of said dressing.

Claim 2

Dependent Claim 105 words

In combination with a synthetic resin wound dressing of the type wherein a particulate, hydrophilic, water swellable polymer of an acrylate or acrylamide, is combined with an inert, non-toxic, water miscible organic solvent of polyethylene glycol, capable of forming a paste with said polymer, the improvement which comprises, a hydrogen bonding plasticizer of dimethylsulfoxide mixed with the combined polymer and solvent, with said polymer ranging between about 30%-55% by weight of said dressing, with said solvent ranging between about 20%-60% by weight of said dressing, and with said plasticizer being present in a plasticizing amount ranging up to about 20% by weight of said dressing.

Claim 3

Dependent Claim 105 words

A synthetic resin wound dressing of the bonding type comprising a particulate, hydrophilic, water swellable polymer of an acrylate or acrylamide, an inert, non-toxic water miscible organic solvent of polyethylene glycol, the improvement which comprises, a hydrogen bonding plasticizer mixed with said polymer and solvent, said plasticizer is a material selected from the group consisting of dimethylsulfoxide, dimethylphthalate, 2,3-butylene carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethylsulfone, methylene glycolate, methylpropyl sulfone, and butyrolactone, said polymer ranging between 30%-55% by weight of said dressing, with said solvent ranging between about 20%-60% by weight of said dressing, and said plasticizer ranging up to about 20% by weight of said dressing.

Claim 4

Dependent Claim 105 words

A synthetic resin wound dressing of the bonding type comprising a particulate, hydrophilic, water swellable polymer of an acrylate or acrylamide, an inert, non-toxic water miscible organic solvent of polyethylene glycol, the improvement which comprises, a hydrogen bonding plasticizer mixed with said polymer and solvent, said plasticizer is a material selected from the group consisting of dimethylsulfoxide, dimethylphthalate, 2,3-butylene carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethylsulfone, methylene glycolate, methylpropyl sulfone, and butyrolactone, said polymer ranging between 30%-55% by weight of said dressing, with said solvent ranging between about 20%-60% by weight of said dressing, and said plasticizer ranging up to about 20% by weight of said dressing.

Claim 5

Dependent Claim 123 words

A synthetic resin wound dressing of the preformed film type bandage comprising a particulate, hydrophilic, water swellable polymer of an acrylate or acrylamide, an inert nontoxic, water miscible organic solvent of polyethylene glycol, the improvement which comprises, a hydrogen bonding plasticizer of dimethylsulfoxide mixed with the combined polymer and solvent, said combination of polymer, solvent, and plasticizer being mixed in combination and cured to form a bandage type dressing with controlled flexibility and elasticity, and having an adherent surface, with said polymer ranging between about 30%-55% by weight of said dressing, with said solvent ranging between about 20%-60% by weight of said dressing, and with said plasticizer being present in a plasticizing amount ranging up to about 20% by weight of said dressing.

Claim 6

Dependent Claim 123 words

A synthetic resin wound dressing of the preformed film type bandage comprising a particulate, hydrophilic, water swellable polymer of an acrylate or acrylamide, an inert nontoxic, water miscible organic solvent of polyethylene glycol, the improvement which comprises, a hydrogen bonding plasticizer of dimethylsulfoxide mixed with the combined polymer and solvent, said combination of polymer, solvent, and plasticizer being mixed in combination and cured to form a bandage type dressing with controlled flexibility and elasticity, and having an adherent surface, with said polymer ranging between about 30%-55% by weight of said dressing, with said solvent ranging between about 20%-60% by weight of said dressing, and with said plasticizer being present in a plasticizing amount ranging up to about 20% by weight of said dressing.

Claim 7

Dependent Claim 66 words

A synthetic resin wound dressing as set forth in claim 1, 2, or 3 and further comprising as a further ingredient a medicament agent, said medicament agent is a material selected from the group consisting of a germicide, a fungicide, an antimicrobial agent, an antibiotic, an analgesic, a hormone agent, an anti-inflammatory agent, a cardiovascular agent, an anticonvulsant agent, a pulmonary agent, and a muscle relaxant.

Claim 8

Dependent Claim 53 words

A synthetic resin wound dressing as set forth in claim 2 or 3 and wherein said dressing comprises, when said polymer, solvent, and hydrogen bonding plasticizer are mixed, a cured bandage type dressing having a controlled increased flexibility, elasticity, and surface adhesion, and which may be stored in bandage type form until usage.

Claim 9

Dependent Claim 112 words

The synthetic resin wound dressing as set forth in claim 1, 2, or 3 wherein said polymer is poly(2-hydroxyethylmethacrylate), said solvent being polyethylene glycol hving a molecular weight ranging between about 200-2000, and said hydrogen bonding plasticizer being dimethylsulfoxide with the amount of said plasticizer directly controlling the set-up of the composition in forming a substantially occlusive film, and with the length of the set-up time decreasing as the quantity of the plasticizer increases such that set-up times of less than about 30 seconds or less may be realized when the above-stated maximum quantity of said plasticizer is present, to about 45 minutes when a minimum amount of said plasticizer is present.

Claim 10

Dependent Claim 19 words

A synthetic resin wound dressing as set forth in claim 1, 2, or 3 wherein said polymer is poly(2-hydroxyethylmethacrylate).

Claim 11

Dependent Claim 25 words

A synthetic resin wound dressing as set forth in claim 7 wherein said solvent is polyethylene glycol having a molecular weight ranging between about 200-2000.

Claim 12

Dependent Claim 32 words

A synthetic resin wound dressing as set forth in claim 1, 2, or 3 wherein said bandage-type dressing comprises a substrate having a layer of said paste applied to one face thereof.

Claim 13

Dependent Claim 19 words

A synthetic resin wound dressing as set forth in claim 9 wherein said substrate is a biaxially stretchable substrate.

Claim 14

Dependent Claim 99 words

A synthetic resin wound dressing as set forth in claim 1, 2, or 3 wherein said polymer is a polymer of hydroxy(C 2 -C 4 -alkyl)methacrylate, hydroxy(C 2 -C 4 alkyl) acrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 -alkyl)methacrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl)acrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl)methacrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl)acrylate, N-(C 1 -C 4 alkyl)acrylamide, N-(C 1 -C 4 alkyl)methacrylamide, N,N-di(C 1 -C 4 -alkyl)acrylamide, N,N-(di(C 1 -C 4 alkyl)methacrylamide, vicinal-epoxy(C 1 -C 4 alkyl)methacrylate, or vicinal-epoxy(C 1 -C 4 alkyl)acrylate.

Claim 15

Dependent Claim 28 words

A synthetic resin wound dressing as set forth in claim 11 wherein said polymer is at least slightly crosslinked and has a molecular weight of at least 50,000.

Claim 16

Dependent Claim 31 words

A synthetic resin wound dressing as set forth in claim 1, 2, or 3 wherein said plasticizer is a liquid having a solubility parameter ranging between about 10.7 to about 12.6.

Claim 17

Dependent Claim 40 words

A synthetic resin wound dressing as set forth in claim 1, 2, or 3 wherein said solvent is polyethylene glycol of the general formula H(OCH 2 CH 2 ) n OH, where n is greater than or equal to 4.

Claim 18

Dependent Claim 33 words

A synthetic resin wound dressing as set forth in claim 14 wherein said polyethylene glycol solvent has a molecular weight ranging between about 200-2000, and has a boiling point of about 200° C.

Claim 19

Dependent Claim 23 words

A synthetic resin wound dressing as set forth in claim 15 wherein said polyethylene glycol has a molecular weight ranging between about 200-800.

Claim 20

Dependent Claim 18 words

A synthetic resin wound dressing as set forth in claim 4 wherein said antimicrobial agent is silver sulfadiazine.

Claim 21

Dependent Claim 30 words

A synthetic resin wound dressing as set forth in claim 17 wherein said silver sulfadiazine is present in said wound dressing ranging between about 0.5 to about 7% by weight.

Claim 22

Dependent Claim 17 words

A synthetic resin wound dressing as set forth in claim 4 wherein said cardiovascular agent is nitroglycerine.

Claim 23

Dependent Claim 29 words

A synthetic resin wound dressing as set forth in claim 19 wherein said nitroglycerine is present in said wound dressing ranging between about 0.5 to about 10% by weight.

Claim 24

Dependent Claim 17 words

A synthetic resin wound dressing as set forth in claim 4 wherein said antimicrobial agent is nitrofurazone.

Claim 25

Dependent Claim 29 words

A synthetic resin wound dressing as set forth in claim 21 wherein said nitrofurazone is present in said wound dressing ranging between about 0.5 to about 10% by weight.

Claim 26

Dependent Claim 18 words

A synthetic resin wound dressing as set forth in claim 4 wherein said antimicrobial agent is silver nitrate.

Claim 27

Dependent Claim 30 words

A synthetic resin wound dressing as set forth in claim 23 wherein said silver nitrate is present in said wound dressing ranging between about 0.5 to about 10% by weight.

Claim 28

Dependent Claim 43 words

A synthetic resin wound dressing as set forth in claim 4 wherein said antimicrobial agent consists essentially of silver sulfadiazine, nitrofurazone, or silver nitrate with the weight of said antimicrobial agent ranging between about 0.5 to about 10% by weight of said dressing.

Claim 29

Dependent Claim 18 words

A synthetic resin wound dressing as set forth in claim 4 wherein said antimicrobial agent is mafenide acetate.

Claim 30

Dependent Claim 30 words

A synthetic resin wound dressing as set forth in claim 26 wherein said mafenide acetate is present in said wound dressing ranging between about 0.5 to about 10% by weight.

Claim 31

Dependent Claim 110 words

A synthetic resin wound dressing comprising a preformed polymer film of poly(hydroxyethylmethacrylate), a solvent of polyethylene glycol, a hydrogen bonding plasticizer of dimethylsulfoxide, and a medicinal agent of silver sulfadiazine, nitrofurazone, silver nitrate, or mafenide acetate, wherein said poly(hydroxyethylmethacrylate) ranges between 30%-55% by weight of said dressing, said polyethylene glycol ranges between about 20%-60% by weight of said dressing, said dimethylsulfoxide being present in a plasticizing amount ranges up to about 20% by weight of said dressing, said medicinal agent, or combinations thereof, ranges between about 0.5% to about 10% by weight of said dressing, and wherein said composition is mixed and formed into a precured bandage type wound dressing.

Claim 32

Dependent Claim 110 words

A synthetic resin wound dressing comprising a preformed polymer film of poly(hydroxyethylmethacrylate), a solvent of polyethylene glycol, a hydrogen bonding plasticizer of dimethylsulfoxide, and a medicinal agent of silver sulfadiazine, nitrofurazone, silver nitrate, or mafenide acetate, wherein said poly(hydroxyethylmethacrylate) ranges between 30%-55% by weight of said dressing, said polyethylene glycol ranges between about 20%-60% by weight of said dressing, said dimethylsulfoxide being present in a plasticizing amount ranges up to about 20% by weight of said dressing, said medicinal agent, or combinations thereof, ranges between about 0.5% to about 10% by weight of said dressing, and wherein said composition is mixed and formed into a precured bandage type wound dressing.

Claim 33

Dependent Claim 132 words

A process of treating a wound site comprising applying a synthetic resin film type bandage wound dressing to the wound site, said wound dressing consisting essentially of a particulate hydrophilic, water swellable polymer of an acrylate or acrylamide, an inert, non-toxic, water miscible, organic solvent of polyethylene glycol, and a hydrogen bonding plasticizer, said plasticizer selected from the group consisting of dimethylsulfoxide, dimethylphthalate, 2,3-butylene carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethylsulfone, methylene glycolate, methylpropyl sulfone, and butryolactone, said polymer, solvent, and plasticizer capable of forming a flexible adherent film dressing, the said polymer ranging between about 30%-55% by weight of said dressing, with said solvent ranging between about 20%-60% by weight of said dressing, and with said plasticizer being present in a plasticizing amount ranging up to about 20% by weight of said dressing.

Claim 34

Dependent Claim 132 words

A process of treating a wound site comprising applying a synthetic resin film type bandage wound dressing to the wound site, said wound dressing consisting essentially of a particulate hydrophilic, water swellable polymer of an acrylate or acrylamide, an inert, non-toxic, water miscible, organic solvent of polyethylene glycol, and a hydrogen bonding plasticizer, said plasticizer selected from the group consisting of dimethylsulfoxide, dimethylphthalate, 2,3-butylene carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethylsulfone, methylene glycolate, methylpropyl sulfone, and butryolactone, said polymer, solvent, and plasticizer capable of forming a flexible adherent film dressing, the said polymer ranging between about 30%-55% by weight of said dressing, with said solvent ranging between about 20%-60% by weight of said dressing, and with said plasticizer being present in a plasticizing amount ranging up to about 20% by weight of said dressing.

Claim 35

Dependent Claim 38 words

The process of claim 29 wherein, said polymer, solvent, and plasticizer are initially mixed, a settable paste results which may be formed into a flexible, elastic and adherent film type bandage for application directly on the wound site.

Claim 36

Dependent Claim 27 words

The process of claim 30 further comprising applying said mixture to an adherent substrate and permitting said mixture to cure thereby to form said preformed bandage-type dressing.

Claim 37

Dependent Claim 27 words

The process of claim 30 further comprising applying said mixture to a non-adherent surface and permitting said mixture to cure thereby to form said preformed bandage-type dressing.

Claim 38

Dependent Claim 43 words

The process of claim 29 further comprising adding a medicament agent, such as a germicide, a fungicide, an antimicrobial agent, an antibiotic, an analgesic, a hormone agent, an anti-inflammatory agent, a cardiovascular agent, an anticonvulsant agent, a pulmonary agent, or a muscle relaxant.

Claim 39

Dependent Claim 29 words

The process of claim 29 wherein said plasticizer is from the group of dimethylsulfoxide, dimethylphthalate, 2,3-butylene carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethyl sulfone, methylene glycolate, methyl propyl sulfone or butyrolactone.

Claim 40

Dependent Claim 10 words

The process of claim 29 wherein said polymer is poly(2-hydroxyethylmethacrylate).

Claim 41

Dependent Claim 19 words

The process of claim 35 wherein said solvent is polyethylene glycol having a molecular weight ranging between about 200-2,000.

Claim 42

Dependent Claim 11 words

The process of claim 36 wherein said plasticizer is preferably dimethylsulfoxide.

Claim 43

Dependent Claim 15 words

The process of claim 29 wherein the dressing is applied to a burn wound site.

Claim 44

Dependent Claim 37 words

The process of claim 38 wherein the dressing comprises an antimicrobial agent such as silver sulfadiazine, silver nitrate, nitrofurazone, mafenide acetate, or mixtures thereof, said antimicrobial agent ranging up to about 10% by weight of said dressing.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1989-01-06	1989-07-08	1990-01-07	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1993-01-06	1993-07-08	1994-01-07	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1997-01-06	1997-07-08	1998-01-07	$7700.00	Window Closed / Lapsed

Synthetic resin wound dressing and method of treatment using same

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