US4342784A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chemical compositions and method of utilization
Assignee: ER Squibb and Sons LLC
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Filing: 1972-06-12
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Granted: 1982-08-03
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Expires: 1992-06-12
Abstract
Abstract Disclosed herein is a pharmaceutically active gelled composition of dimethyl sulfoxide for utilization in the treatment of musculoskeletal disorders.
Inventors
- 👤 Ruth N. Havemeyer
- 👤 Gilman N. Cyr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:27
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K47/00; A61K47/30; A61K47/32; A61K47/36; A61K47/38
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
186 words
A method of administering liquid dimethylsulfoxide cutaneously and topically to humans and animals in amounts effective for therapeutic action without having the dimethylsulfoxide run off the skin and without causing significant irritation of the skin, said method comprising (a) applying to the surface of the skin at and surrounding the site of the disorder being treated an ionicly sensitive, semi-solid gel consisting essentially of (i) a mixture of dimethylsulfoxide and water wherein the dimethylsulfoxide is present in a concentration of about 99.8% to about 10% by weight in the gel composition, (ii) carboxy polymethylene water-soluble resin in an amount from about 0.2% to about 20.0% by weight of the gel composition and, (iii) a neutralizing agent selected from the group consisting of triethanolamine, N-methylglucamine, sodium hydroxide, triethylamine, or monoethanolamine; and (b) maintaining said semi-solid gel in contact with said skin for a period sufficient to enable the salt normally present at the surface of the skin to gradually break the semi-solid gel composition and thereby slowly release the liquid mixture of dimethylsulfoxide and water over the surface of the skin where the semi-solid gel was applied.
Claim 2
Independent Claim
186 words
A method of administering liquid dimethylsulfoxide cutaneously and topically to humans and animals in amounts effective for therapeutic action without having the dimethylsulfoxide run off the skin and without causing significant irritation of the skin, said method comprising (a) applying to the surface of the skin at and surrounding the site of the disorder being treated an ionicly sensitive, semi-solid gel consisting essentially of (i) a mixture of dimethylsulfoxide and water wherein the dimethylsulfoxide is present in a concentration of about 99.8% to about 10% by weight in the gel composition, (ii) carboxy polymethylene water-soluble resin in an amount from about 0.2% to about 20.0% by weight of the gel composition and, (iii) a neutralizing agent selected from the group consisting of triethanolamine, N-methylglucamine, sodium hydroxide, triethylamine, or monoethanolamine; and (b) maintaining said semi-solid gel in contact with said skin for a period sufficient to enable the salt normally present at the surface of the skin to gradually break the semi-solid gel composition and thereby slowly release the liquid mixture of dimethylsulfoxide and water over the surface of the skin where the semi-solid gel was applied.
Claim 3
Dependent Claim
25 words
The method of claim 1, wherein the dimethylsulfoxide is present in a concentration of about 99.8% to about 90% by weight in the gel composition.
Claim 4
Dependent Claim
27 words
The method of claim 2, wherein the carboxy polymethylene water-soluble resin is present in an amount from about 1% to about 2% by weight of the dimethylsulfoxide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-02 | 1986-02-01 | 1986-08-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-02 | 1990-02-01 | 1990-08-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-02 | 1994-02-01 | 1994-08-03 | $7700.00 | Window Closed / Lapsed |