US4472303A
Expired / Lapsed
US
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Blood purification method
Assignee: Kuraray Co Ltd
•
Filing: 1983-08-22
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Granted: 1984-09-18
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Expires: 2003-08-22
Abstract
Abstract Treatment of the blood by means of a blood purification device comprising packed, substantially spherical, smooth-surfaced, porous granules having at least 0.1 μmole/m 2 of the silanol group on the surface thereof, a blood inlet and a blood outlet scarcely causes decrease in leukocyte or platelet count or blood cell damage and can remove proteins from the blood by adsorption without high pressure loss.
Inventors
- 👤 Masao Tanihara
- 👤 Toshihide Nakashima
- 👤 Koichi Takakura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 16:05
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; B; B01; B01D; B01D15/00; B01D15/08; B01J; B01J20/00; B01J20/28; B01J20/28002; B01J20/28004; B01J20/28014; B01J20/28016; B01J20/28019; B01J20/28054; B01J20/28069; B01J20/28078; B01J20/30; B01J20/3078; B01J20/3085; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/327; B01J2220/00; B01J2220/50; B01J2220/58; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
57 words
A method of purifying the blood which comprises contracting the blood with substantially spherical, porous granules made of a material selected from the group consisting of porous glass, porous silica, and silica-alumina and having at least 0.1μ mole/m 2 of the silanol group on the surface thereof and thereby removing a protein from the blood by adsorption.
Claim 2
Independent Claim
57 words
A method of purifying the blood which comprises contracting the blood with substantially spherical, porous granules made of a material selected from the group consisting of porous glass, porous silica, and silica-alumina and having at least 0.1μ mole/m 2 of the silanol group on the surface thereof and thereby removing a protein from the blood by adsorption.
Claim 3
Dependent Claim
30 words
A method of purifying the blood as claimed in claim 1, wherein the spherical porous granules have a mean pore diameter of 350-900 angstroms and the protein fraction includes γ-globulin.
Claim 4
Dependent Claim
32 words
A method of purifying the blood as claimed in claim 1, wherein the spherical porous granules have a mean pore diameter of 900-1,600 angstroms and the protein fraction includes the low-density lipoprotein.
Claim 5
Dependent Claim
29 words
A method of purifying the blood as claimed in claim 1, the majority of the spherical porous granules a diameter within the range of 0.1 mm to 5 mm.
Claim 6
Dependent Claim
31 words
A method of purifying the blood as claimed in claim 1, wherein the majority of the spherical porous granules have a diameter within the range of 0.5 mm to 1 mm.
Claim 7
Dependent Claim
29 words
A method of purifying the blood as claimed in claim 1, wherein the spherical porous granules have a pore volume within the range of 0.3 cc/g to 2.0 cc/g.
Claim 8
Dependent Claim
29 words
A method of purifying the blood as claimed in claim 1, wherein the spherical porous granules have a pore diameter within the range of 20 angstroms to 3,000 angstroms.
Claim 9
Dependent Claim
42 words
A method of purifying the blood as claimed in claim 1, wherein the ratio of the volume occupied by pores with diameters within the range of 0.8D-1.2D to the whole pore volume is at least 80%, D being the mean pore diameter.
Claim 10
Dependent Claim
21 words
A method of purifying the blood as claimed in claim 1, wherein the spherical porous granules are made of porous glass.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-18 | 1988-03-19 | 1988-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-18 | 1992-03-19 | 1992-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-18 | 1996-03-19 | 1996-09-18 | $7700.00 | Window Closed / Lapsed |