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US4029583A Expired / Lapsed US ⏱️ 0.0 years remaining

Chromatographic supports and methods and apparatus for preparing the same

Assignee: Purdue Research Foundation
•
Filing: 1975-02-28
•
Granted: 1977-06-14
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Expires: 1995-02-28
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Abstract

Abstract Chromatographic supports are disclosed as are methods and apparatus for preparing the same. The support includes an inorganic support matrix that is capable of reacting with silanols, a stationary phase, and an intermediate silane coupling agent having a silicon functional group capable of bonding to the support surface and an organic functional group capable of bonding to the stationary phase. The inorganic support matrix is preferably controlled porosity glass or silica while the coupling agent may include a simple carbohydrate, a carbohydrate derivative, or a polymer to which the stationary phase is attached. A plurality of chromatographic supports and stationary phases are disclosed and two methods of bonding of stationary phases to supports are also disclosed. In addition, apparatus including a fluidized bed is also disclosed to prepare supports.

Inventors

  • 👤 Shung Ho Chang
  • 👤 Frederick E. Regnier

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-25 13:41
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/30; B01J20/32; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3257; B01J20/02; B01J20/10; B01J20/103; B01J20/281; B01J20/286; B01J20/289; B01J20/3202; B01J20/3204; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3268; B01J20/3272; B01J20/3285; C; C12; C12N; C12N11/00; C12N11/14

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 75 words
A chromatographic support, comprising: an inorganic support matrix having a surface portion; a stationary phase for partitioning solutes, said stationary phase being a glycidyl ether selected from the group consisting of methanol, ethanol, propanol, hexanol, tetradecanol, phenol, and p-nitrophenol, a nucleophilic functional group, and a leaving group; and a silane coupling agent having one group for bonding to said surface portion of said support matrix and a second group for bonding to the stationary phase.
Claim 2
Dependent Claim 75 words
A chromatographic support, comprising: an inorganic support matrix having a surface portion; a stationary phase for partitioning solutes, said stationary phase being a glycidyl ether selected from the group consisting of methanol, ethanol, propanol, hexanol, tetradecanol, phenol, and p-nitrophenol, a nucleophilic functional group, and a leaving group; and a silane coupling agent having one group for bonding to said surface portion of said support matrix and a second group for bonding to the stationary phase.
Claim 3
Dependent Claim 30 words
The chromatographic support of claim 1 wherein said stationary phase contains a nucleophilic functional group selected from the group consisting of OH, NH, HSO 3 , and HPO 4 .
Claim 4
Dependent Claim 24 words
The chromatographic support of claim 1 wherein said stationary phase contains a leaving group selected from the group consisting of Cl, Br, and tosylate.

References Cited (Backward Citations)

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US3514925A Cited
US3500616A Cited
US3657117A Cited
US3664967A Cited
US3722181A Cited
US3795313A Cited
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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-06-13 1980-12-13 1981-06-14 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-06-13 1984-12-13 1985-06-14 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-06-13 1988-12-13 1989-06-14 $7700.00 Window Closed / Lapsed

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