US4171283A
Expired / Lapsed
US
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Hemoperfusion adsorbents
Assignee: Kuraray Co Ltd
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Filing: 1977-07-29
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Granted: 1979-10-16
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Expires: 1997-07-29
Abstract
Abstract A hemoperfusion adsorbent is provided comprising an adsorbent material containing at least one coating thereon of a hydrophilic polymer prepared by the polymerization of at least one monomeric acrylate or methacrylate with a copolymerizable monomer containing an epoxy moiety therein.
Inventors
- 👤 Toshihide Nakashima
- 👤 Koichi Takakura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 05:30
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61M; A61M1/00; A61M1/36; A61M1/3679; B; B01; B01J; B01J20/00; B01J20/02; B01J20/20; B01J20/22; B01J20/26; B01J20/261; B01J20/264; B01J20/265; B01J20/267; B01J20/28; B01J20/28002; B01J20/28004; B01J20/28014; B01J20/28016; B01J20/28019; B01J20/30; B01J20/3078; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/327; B01J20/3276; B01J20/328; B01J20/3282; C; C01; C01B; C01B32/00; C01B32/30; C01B32/354; C01B32/372; C08; C08F; C08F292/00; D; D01; D01F; D01F11/00; D01F11/10; D01F11/12; D01F11/122; B01J2220/00; B01J2220/40; B01J2220/48; B01J2220/4812; B01J2220/50; B01J2220/58
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
207 words
A hemoperfusion adsorbent comprising an adsorbent material containing at least one coating thereon of a hydrophilic polymer prepared by the polymerization of at least one monomeric acrylate or methacrylate represented by the formula: ##STR3## wherein Y is a radical selected from the group consisting of --R 2 --OR 3 and --R 2 --NR 3 R' 3 , R 1 is hydrogen or methyl, R 2 is a divalent alkylene radical containing 2 to 3 carbon atoms or a poly(oxyalkylene) radical, and R 3 and R' 3 , respectively, are hydrogen or an alkyl group containing 1 to 3 carbon atoms which can be substituted with polar radicals, with a copolymerizable monomer containing an epoxy moiety therein represented by the formula: ##STR4## wherein Z is a divalent radical selected from the group consisting of --COO--R 2 -- and --CH 2 --OCH 2 --, n is 0 or 1, R 1 , R' 1 and R" 1 are each, respectively, hydrogen or methyl and R 2 is a divalent alkylene radical containing 1 to 3 carbon atoms or a poly(oxyalkylene) radical, wherein the feed ratio of the copolymerizable monomer containing an epoxy moiety therein in the polymerization ranges from 0.1 to 10% based on the weight of total monomers.
Claim 2
Dependent Claim
207 words
A hemoperfusion adsorbent comprising an adsorbent material containing at least one coating thereon of a hydrophilic polymer prepared by the polymerization of at least one monomeric acrylate or methacrylate represented by the formula: ##STR3## wherein Y is a radical selected from the group consisting of --R 2 --OR 3 and --R 2 --NR 3 R' 3 , R 1 is hydrogen or methyl, R 2 is a divalent alkylene radical containing 2 to 3 carbon atoms or a poly(oxyalkylene) radical, and R 3 and R' 3 , respectively, are hydrogen or an alkyl group containing 1 to 3 carbon atoms which can be substituted with polar radicals, with a copolymerizable monomer containing an epoxy moiety therein represented by the formula: ##STR4## wherein Z is a divalent radical selected from the group consisting of --COO--R 2 -- and --CH 2 --OCH 2 --, n is 0 or 1, R 1 , R' 1 and R" 1 are each, respectively, hydrogen or methyl and R 2 is a divalent alkylene radical containing 1 to 3 carbon atoms or a poly(oxyalkylene) radical, wherein the feed ratio of the copolymerizable monomer containing an epoxy moiety therein in the polymerization ranges from 0.1 to 10% based on the weight of total monomers.
Claim 3
Dependent Claim
24 words
A hemoperfusion adsorbent as defined in claim 1 wherein the adsorbent material comprises adsorbent particles having a diameter from about 0.1 to 5 mm.
Claim 4
Dependent Claim
14 words
A hemoperfusion adsorbent as defined in claim 2 wherein the adsorbent is activated carbon.
Claim 5
Dependent Claim
20 words
A hemoperfusion adsorbent as defined in claim 3 wherein the activated carbon is bead activated carbon manufactured from petroleum pitch.
Claim 6
Dependent Claim
8 words
The heat cured hemoperfusion adsorbent of claim 1.
Claim 7
Dependent Claim
41 words
A hemoperfusion adsorbent as defined in claim 1 which has been substantially freed from air bubbles by boiling said adsorbent in water or physiological saline, cooling said adsorbents, packing said adsorbents into a container and sterilizing the packed container by autoclaving.
Claim 8
Dependent Claim
27 words
A hemoperfusion adsorbent as defined in claim 6 wherein sterilization is effected by introducing water vapor into the autoclave at a temperature of at least 120° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-10-15 | 1983-04-16 | 1983-10-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-10-15 | 1987-04-16 | 1987-10-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-10-15 | 1991-04-16 | 1991-10-16 | $7700.00 | Window Closed / Lapsed |