US4404285A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing a zero standard serum
Assignee: Specialty Materials Inc
•
Filing: 1981-06-24
•
Granted: 1983-09-13
•
Expires: 2001-06-24
Abstract
Abstract A method for the removal of hormones from whole human serum which comprises: contacting, at a pressure higher than 1 psi the serum with a composite sheet, the composite sheet comprising a matrix of self-bonding fibers having interdispersed therein carbon particles, such that better than 90% of the carbon particles have an average diameter less than about 50 microns; and recovering a whole human serum having substantially undetectable amounts of hormones. The method is particularly useful for the removal of thyroid hormones.
Inventors
- 👤 Kenneth C. Hou
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 10:25
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; B; B01; B01D; B01D15/00; B01D15/08; G01N2496/00; G01N2496/05; G01N33/74; G01N33/78; Y; Y10; Y10S; Y10S435/00; Y10S435/97; Y10T; Y10T436/00; Y10T436/10; Y10T436/106664; Y10T436/107497; Y10T436/25; Y10T436/25375
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
71 words
A method for the removal of thyroid hormones from human serum which comprises: flowing, at a pressure differential higher than 1 psi, said serum through a column containing a composite sheet, said composite sheet comprising a matrix of self-bonding fibers having interdispersed therein carbon particles, such that better than 90% of said carbon particles have an average diameter less than about 50 microns; thereby removing said thyroid hormones from said serum.
Claim 2
Independent Claim
71 words
A method for the removal of thyroid hormones from human serum which comprises: flowing, at a pressure differential higher than 1 psi, said serum through a column containing a composite sheet, said composite sheet comprising a matrix of self-bonding fibers having interdispersed therein carbon particles, such that better than 90% of said carbon particles have an average diameter less than about 50 microns; thereby removing said thyroid hormones from said serum.
Claim 3
Dependent Claim
21 words
The method of claim 1 wherein said thyroid hormones are selected from the group consisting of thyroxine, tri-iodo thyronine and cortisol.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein said pressure is 1-200 psi.
Claim 5
Dependent Claim
15 words
The method of claim 1 wherein said composite sheet comprises cellulose fiber and activated carbon.
Claim 6
Dependent Claim
21 words
The method of claim 4 wherein said cellulose fiber comprises 2-10: 1 by weight ratio of unrefined to highly refined pulp.
Claim 7
Dependent Claim
24 words
The method of claim 5 wherein said highly refined pulp has a Canadian Standard Freeness (CSF) value in the range +100 to -600 ml.
Claim 8
Dependent Claim
22 words
The method of claim 5 wherein said unrefined pulp has a Canadian Standard Freeness value in the range +400 to +800 ml.
Claim 9
Dependent Claim
18 words
The method of claim 5 wherein said unrefined pulp comprises 10-30% of the total weight of the sheet.
Claim 10
Dependent Claim
19 words
The method of claim 5 wherein said highly refined pulp comprises 1-15% of the total weight of the sheet.
Claim 11
Dependent Claim
32 words
The method of claim 5 wherein said unrefined pulp comprises 18-20% of the total weight of the sheet, and said highly refined pulp comprises 8-10% of the total weight of the sheet.
Claim 12
Dependent Claim
16 words
The method of claim 4 wherein said carbon is present in said sheet in hormone-adsorbing amounts.
Claim 13
Dependent Claim
17 words
The method of claim 11 wherein said amount is 10-90% of the total weight of said sheet.
Claim 14
Dependent Claim
22 words
The method of claim 4 wherein said sheet also comprises thyroid hormone adsorbing amounts of thyroid hormone adsorbing materials other than carbon.
Claim 15
Dependent Claim
28 words
The method of claim 1 wherein said composite sheet is present in the form of a plurality of essentially circular pads fitting the inside of a cylindrical column.
Claim 16
Dependent Claim
25 words
The method of claim 14 wherein the starting whole serum is allowed to flow through the column and sequentially contact each of said circular pads.
Claim 17
Dependent Claim
14 words
The method of claim 15 wherein said serum is recycled through said pad-containing column.
Claim 18
Independent Claim
18 words
The method of any one of claims 1-13 wherein said removal is carried out at normal serum pH.
References Cited (Backward Citations)
US1787467A
Cited
US3149023A
Cited
US3442819A
Cited
US3414383A
Cited
US3615222A
Cited
US3666854A
Cited
US3743482A
Cited
US3775615A
Cited
US3776698A
Cited
US3911096A
Cited
US3953360A
Cited
US4321288A
Cited
US4076892A
Cited
US3972818A
Cited
US4147764A
Cited
US4309247A
Cited
US4169051A
Cited
US4115534A
Cited
US4115537A
Cited
US4197287A
Cited
US4139604A
Cited
US4305782A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-12 | 1987-03-14 | 1987-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-12 | 1991-03-14 | 1991-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-12 | 1995-03-14 | 1995-09-13 | $7700.00 | Window Closed / Lapsed |