Patent US4366310A successfully refreshed from Google Patents.
US4366310A
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US
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Controlled release compositions
Assignee: Euro Celtique SA
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Filing: 1980-12-10
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Granted: 1982-12-28
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Expires: 2000-12-10
Abstract
Abstract Molecular coordination complexes are formed between a cellulose polymer and a non-polar solid aliphatic alcohol containing 8 to 18 carbon atoms optionally substituted with an aliphatic group containing 8 to 18 carbon atoms by solvating the polymer with a volatile polar solvent and reacting the solvated cellulose polymer directly with the aliphatic alcohol, preferably as a melt. The resulting composition may be dried. This constitutes the complex. The composition has utility as a matrix in controlled release formulations since it has a uniform porosity which may be varied.
Inventors
- 👤 Stewart T. Leslie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 02:24
CPC Classifications
C; C08; C08B; C08B11/00; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013; A61K9/2022; A61K9/205; A61K9/2054; C08K; C08K5/00; C08K5/04; C08K5/05
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
44 words
A molecular coordination complex of a cellulose polymer and a solid aliphatic alcohol selected from the group consisting of unsubstituted solid aliphatic alcohols of 8-18 carbon atoms and solid aliphatic alcohols of 8-18 carbon atoms substituted by an aliphatic group of 8-18 carbon atoms.
Claim 2
Dependent Claim
44 words
A molecular coordination complex of a cellulose polymer and a solid aliphatic alcohol selected from the group consisting of unsubstituted solid aliphatic alcohols of 8-18 carbon atoms and solid aliphatic alcohols of 8-18 carbon atoms substituted by an aliphatic group of 8-18 carbon atoms.
Claim 3
Dependent Claim
15 words
Molecular coordination complex of claim 1 wherein said cellulose polymer is a hydroxy alkyl cellulose.
Claim 4
Dependent Claim
25 words
Molecular coordination complex according to claim 1 wherein the number of carbon atoms of the solid aliphatic alcohol is between 10 and 18 carbon atoms.
Claim 5
Dependent Claim
32 words
Molecular coordination complex according to claim 1 wherein said cellulose polymer is hydroxymethyl cellulose, hydroxyethyl cellulose or hydroxypropyl cellulose and wherein the aliphatic alcohol is lauryl, myristyl, cetyl, stearyl or cetostearyl alcohol.
Claim 6
Dependent Claim
18 words
Controlled release pharmaceutical composition comprising an active pharmaceutical agent distributed in the molecular coordination complex of claim 1.
Claim 7
Dependent Claim
23 words
Composition according to claim 5 wherein the amount of said molecular coordination complex is more than 20% of the weight of the composition.
Claim 8
Dependent Claim
46 words
Method of producing the molecular coordination complex of claim 1, which comprises solvating the cellulose polymer with a volatile polar solvent therefor to form a solvated cellulose polymer and reacting the thus solvated cellulose polymer with said solid aliphatic alcohol, thereby forming said molecular coordination complex.
Claim 9
Dependent Claim
43 words
Method according to claim 7 wherein said solvated cellulose polymer is introduced into a melt of said solid aliphatic alcohol so as to cause reaction therebetween, cooling the thus formed reaction mass and drying the same to remove any residual volatile polar solvent.
Claim 10
Dependent Claim
24 words
Method according to claim 8 wherein 1-6 parts by weight of said volatile polar solvent are used per each part of said cellulose polymer.
Claim 11
Dependent Claim
21 words
Method according to claim 8 wherein one part of aliphatic alcohol is used per each part of said volatile polar solvent.
Claim 12
Dependent Claim
12 words
The molecular coordination complex of claim 1 wherein said complex is porous.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-12-27 | 1986-06-28 | 1986-12-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-12-27 | 1990-06-28 | 1990-12-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-12-27 | 1994-06-28 | 1994-12-28 | $7700.00 | Window Closed / Lapsed |