US4258179A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coating agents for solid medicaments
Assignee: Astellas Pharma Inc
•
Filing: 1978-12-20
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Granted: 1981-03-24
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Expires: 1998-12-20
Abstract
Abstract A novel coating agent for solid medicaments containing a hydrogel-like substance of a water-insoluble hydroxypropyl cellulose having 5-16% by weight of a hydroxypropoxy group or the dry powder of a hydrogel-like substance. By coating solid medicaments with the coating agent, solid medicaments having high impact resistance and showing very less aging can be provided advantageously in industry.
Inventors
- 👤 Hiroitsu Kawata
- 👤 Tadayoshi Ohmura
- 👤 Hiroyoshi Shiozawa
- 👤 Munetaka Hattori
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:39
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2991; Y10T428/2998
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
24 words
A composition for coating a solid medicament comprising a hydrogel-like substance of a water-insoluble hydroxypropyl cellulose containing 5-16% by weight of a hydroxypropoxy group.
Claim 2
Dependent Claim
24 words
A composition for coating a solid medicament comprising a hydrogel-like substance of a water-insoluble hydroxypropyl cellulose containing 5-16% by weight of a hydroxypropoxy group.
Claim 3
Dependent Claim
16 words
A coating composition according to claim 1 which is in the form of a dry powder.
Claim 4
Dependent Claim
41 words
A coating composition for a solid medicament as claimed in claim 1 wherein said coating composition is in a liquid state and contains the hydrogel-like substance or the dry powder thereof in an amount of 0.1-30% by weight as hydroxypropyl cellulose.
Claim 5
Dependent Claim
43 words
A coating composition for a solid medicament as claimed in claim 1 or 3 wherein said coating composition is a sugar coating agent and contains the hydrogel-like substance or the dry powder thereof in an amount of 0.1-15% by weight as hydroxypropyl cellulose.
Claim 6
Dependent Claim
35 words
A coating composition for a solid medicament as claimed in claim 4 wherein said coating composition contains the hydrogel-like substance or the dry powder thereof in an amount of 1-10% by weight as hydroxypropyl cellulose.
Claim 7
Dependent Claim
45 words
A coating composition for a solid medicament as claimed in claim 5 wherein said coating composition contains the hydrogel-like substance or the dry powder thereof in an amount of 1-10% by weight as hydroxypropyl cellulose and calcium lactate in an amount of 1-20% by weight.
Claim 8
Dependent Claim
45 words
A coating composition for a solid medicament as claimed in claim 1 or 3 wherein said coating composition is a sugar coating agent for spraying and contains the hydrogel-like substance or the dry powder thereof in an amount of 0.1-10% by weight as hydroxypropyl cellulose.
Claim 9
Dependent Claim
36 words
A coating composition for a solid medicament as claimed in claim 7 wherein said sugar coating composition contains the hydrogel-like substance or the dry powder thereof in an amount of 3-7% by weight as hydroxypropyl cellulose.
Claim 10
Dependent Claim
46 words
A coating composition for a solid medicament as claimed in claim 8 wherein said sugar coating composition contains the hydrogel-like substance or the dry powder thereof in an amount of 3-7% by weight as hydroxypropyl cellulose and calcium lactate in an amount of 3-15% by weight.
Claim 11
Dependent Claim
42 words
A coating composition for a solid medicament as claimed in claim 1 or 3 wherein said coating composition is a film coating agent containing the hydrogel-like substance or the dry powcer thereof in an amount of 1-10% by weight as hydroxypropyl cellulose.
Claim 12
Dependent Claim
29 words
A coating composition for a solid medicament as claimed in claim 3 wherein said coating composition is in a powder state containing the dry powder of the hydrogel-like substance.
Claim 13
Dependent Claim
22 words
A method of coating solid medicament which comprises coating a solid medicament with the coating composition of claim 1 or claim 2.
Claim 14
Dependent Claim
15 words
A solid medicament which is coated with the coating composition of claim 1 or 3.
Claim 15
Independent Claim
36 words
A method of producing a hydrogel-like substance which comprises grinding or kneading 1 part by weight of water-insoluble hydroxypropyl cellulose containing 5-16% by weight of a hydroxypropoxy group in the presence of 5-20 parts of water.
Claim 16
Independent Claim
36 words
A method of producing a hydrogel-like substance which comprises grinding or kneading 1 part by weight of water-insoluble hydroxypropyl cellulose containing 5-16% by weight of a hydroxypropoxy group in the presence of 5-20 parts of water.
Claim 17
Dependent Claim
13 words
A method according to claim 14 wherein 7-13 parts of water is used.
Claim 18
Dependent Claim
24 words
A method according to claim 14 wherein the hydrogel-like substance is obtained in the form of a dry powder by drying the final mixture.
Claim 19
Dependent Claim
21 words
A hydrogel-like substance of a water-insoluble hydroxypropyl cellulose containing 5-16% by weight of a hydroxypropyl group or the dry powder thereof.
Claim 20
Dependent Claim
21 words
A hydrogel-like substance of a water-insoluble hydroxypropyl cellulose containing 5-16% by weight of a hydroxypropyl group or the dry powder thereof.
Claim 21
Dependent Claim
8 words
The product of the process of claim 14.
Claim 22
Dependent Claim
19 words
A composition for coating a solid medicament comprising the product of claim 18 and sugar or a film-forming agent.
Claim 23
Dependent Claim
85 words
A compound according to claim 17 having a decomposition starting temperature in the dry powder form of about 15° C. higher than untreated hydroxypropyl cellulose, having the same X-ray diffraction curve at d=4.44 A but having a full width of half maximum smaller than untreated hydroxypropyl cellulose, having a more amorphous crystalline structure than untreated hydroxypropyl cellulose as observed from a polarizing microphotograph, and having a fused substance-like appearance as observed from electron microphotographs as compared with untreated hydroxypropyl cellulose which has a fibrous crystal.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-23 | 1984-09-22 | 1985-03-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-23 | 1988-09-22 | 1989-03-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-23 | 1992-09-22 | 1993-03-24 | $7700.00 | Window Closed / Lapsed |