US4264766A
Expired / Lapsed
US
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Immunological diagnostic reagents
Assignee: Roche Diagnostics Corp
•
Filing: 1978-09-11
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Granted: 1981-04-28
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Expires: 1998-09-11
Abstract
Abstract A water-insoluble immunological reagent being formed from discrete particles of a latex carrier to which a water-soluble polyhydroxy compound is covalently bound having condensed thereto through a covalent link an immunologically active material; process for the manufacture of said reagent; a kit containing said reagent and the use of said reagent in immunological determinations.
Inventors
- 👤 Ernst A. Fischer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:54
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0021; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; Y; Y10; Y10S; Y10S436/00; Y10S436/823; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
63 words
A latex composition comprising discrete particles of a latex carrier having reactive functional groups selected from a group consisting of carboxyl, amino, amido or nitrile, said latex particles being covalently bonded through said functional group to a polyhydroxy compound, said particles having a size in the range of from about 0.01 microns to about 0.9 microns and a specific gravity of about 1.0.
Claim 2
Dependent Claim
63 words
A latex composition comprising discrete particles of a latex carrier having reactive functional groups selected from a group consisting of carboxyl, amino, amido or nitrile, said latex particles being covalently bonded through said functional group to a polyhydroxy compound, said particles having a size in the range of from about 0.01 microns to about 0.9 microns and a specific gravity of about 1.0.
Claim 3
Dependent Claim
74 words
A latex composition comprising discrete particles of a latex carrier having a reactive functional group selected from the group consisting of carboxyl, amino, amido and nitrile, said latex particles being covalently bonded through said functional grop to a polyhydroxy compound, and said polyhydroxy compound being activated with an oxidizing agent, said particles having a size in the range of from about 0.01 microns to about 0.9 microns and a specific gravity of about 1.0.
Claim 4
Dependent Claim
74 words
A latex composition comprising discrete particles of a latex carrier having a reactive functional group selected from the group consisting of carboxyl, amino, amido and nitrile, said latex particles being covalently bonded through said functional grop to a polyhydroxy compound, and said polyhydroxy compound being activated with an oxidizing agent, said particles having a size in the range of from about 0.01 microns to about 0.9 microns and a specific gravity of about 1.0.
Claim 5
Dependent Claim
13 words
The latex of claim 1 wherein said latex carrier is a carboxylated latex.
Claim 6
Dependent Claim
15 words
The latex of claim 3 wherein said carboxylated latex is a carboxylated styrene butadiene copolymer.
Claim 7
Dependent Claim
18 words
The latex of claim 1 wherein the water-soluble polyhydroxy compound is a water-soluble polysaccharide or a derivative thereof.
Claim 8
Dependent Claim
12 words
The latex of claim 5 wherein said water-soluble polysaccharide is an aminopolysaccharide.
Claim 9
Dependent Claim
10 words
The latex of claim 6 wherein the aminopolysaccharide is 1-amino-2-hydroxypropyldextran.
Claim 10
Dependent Claim
27 words
The latex of claim 1 wherein the ratio of said carrier latex to said water-soluble polyhydroxy compound is from about 2 to about 50 parts by volume.
Claim 11
Dependent Claim
79 words
The process for the production of a latex composition comprising reacting an aqueous suspension containing discrete particles of a latex carrier having reactive functional groups selected from the group consisting of amino, carboxyl, amido and nitrile with a water soluble polyhydroxy compound to covalently bond said polyhydroxy compound through said functional group to said latex particles, said particles having a size in the range of from about 0.01 to about 0.9 microns and a specific gravity of about 1.0.
Claim 12
Dependent Claim
79 words
The process for the production of a latex composition comprising reacting an aqueous suspension containing discrete particles of a latex carrier having reactive functional groups selected from the group consisting of amino, carboxyl, amido and nitrile with a water soluble polyhydroxy compound to covalently bond said polyhydroxy compound through said functional group to said latex particles, said particles having a size in the range of from about 0.01 to about 0.9 microns and a specific gravity of about 1.0.
Claim 13
Dependent Claim
90 words
A process for the manufacture of a latex composition comprising reacting an aqueous suspension containing discrete particles of a latex carrier having reactive functional groups selected from the group consisting of carboxyl, amino, amido and nitrile with a water soluble polyhydroxy compound to covalently bond said latex particles through said functional group to said polyhydroxy compound and thereafter treating said reacted latex particles with an oxidizing agent, said particles having a size in the range of from about 0.01 to about 0.9 microns and a specific gravity of about 1.0.
Claim 14
Dependent Claim
90 words
A process for the manufacture of a latex composition comprising reacting an aqueous suspension containing discrete particles of a latex carrier having reactive functional groups selected from the group consisting of carboxyl, amino, amido and nitrile with a water soluble polyhydroxy compound to covalently bond said latex particles through said functional group to said polyhydroxy compound and thereafter treating said reacted latex particles with an oxidizing agent, said particles having a size in the range of from about 0.01 to about 0.9 microns and a specific gravity of about 1.0.
Claim 15
Dependent Claim
12 words
The latex of claim 10 wherein the oxidizing agent is a periodate.
Claim 16
Dependent Claim
33 words
The process of claim 9 wherein the latex is a carboxylated polymer and the water-soluble polyhydroxy compound an amino polysaccharide and said reaction is carried out in the presence of a coupling agent.
Claim 17
Dependent Claim
13 words
The process of claim 9 wherein the coupling agent is a water-soluble carbodiimide.
Claim 18
Dependent Claim
19 words
The process of claim 9 wherein activated latex reacted with the polyhydroxy compound is treated with an activating agent.
Claim 19
Dependent Claim
26 words
The process of claim 10 wherein said polyhydroxy compound is an amino polysaccharide and said reaction is carried out in the presence of a coupling agent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-27 | 1984-10-27 | 1985-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-27 | 1988-10-27 | 1989-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-27 | 1992-10-27 | 1993-04-28 | $7700.00 | Window Closed / Lapsed |