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US4292299A
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Slow-releasing medical preparation to be administered by adhering to a wet mucous surface
Assignee: Teijin Ltd
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Filing: 1980-07-07
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Granted: 1981-09-29
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Expires: 2000-07-07
Abstract
Abstract PCT No. PCT/JP79/00284 Sec. 371 Date Nov. 6, 1979 Sec. 102(e) Date July 7, 1980 PCT Filed July 7, 1980 PCT Pub. No. WO80/00916 PCT Pub. Date May 15, 1980 A medical preparation composed of an adhesive layer comprising polymers which have adhesiveness to a wet mucous surface and swellability upon moistening and a nonadhesive layer which has no adhesiveness to a wet mucous surface and is water soluble or water disintegrable, with at least one of the layers made to contain a medicament. The medical preparation is administered by adhering to a wet mucous surface of the mucous membrane and skin of men or animals, whereby exhibiting a property to release the medicament slowly extending over a long period of time to cure or prevent general or local diseases.
Inventors
- 👤 Yoshiki Suzuki
- 👤 Hiroshi Ikura
- 👤 Gentaro Yamashita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:25
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2086; A61K9/209; A61K9/0012; A61K9/0053; A61K9/006; A61K9/70
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
74 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface comprising an adhesive layer composed of a polymer which has the adhesiveness to a wet mucous surface and a property to swell upon moistening and a nonadhesive, either water soluble or disintegrable, layer which has no adhesiveness to a wet mucous surface and at least either one of said adhesive layer and nonadhesive layer is made to contain a medicament.
Claim 2
Dependent Claim
74 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface comprising an adhesive layer composed of a polymer which has the adhesiveness to a wet mucous surface and a property to swell upon moistening and a nonadhesive, either water soluble or disintegrable, layer which has no adhesiveness to a wet mucous surface and at least either one of said adhesive layer and nonadhesive layer is made to contain a medicament.
Claim 3
Dependent Claim
31 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein a medicament is contained in the adhesive layer as an intimate mixture.
Claim 4
Dependent Claim
31 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the thickness of the adhesive layer is about 0.1 to 2.5 mm.
Claim 5
Dependent Claim
34 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the adhesive layer has the adhesiveness of about 40 g/cm 2 (adhesion area) or more.
Claim 6
Dependent Claim
31 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the preparation assumes the form of a tablet consisting of two layers.
Claim 7
Dependent Claim
82 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the polymer of the adhesive layer is at least one polymer selected from a group comprising acrylic acids or their pharmaceutically acceptable nontoxic salts, copolymers of acrylic acid or their pharmaceutically acceptable nontoxic salts, hydrophilic vinyl copolymers not copolymerized with acrylic acid as a main component, hydrophilic cellulose derivatives, polysaccharides or their derivatives and gelatine or collagen or their derivatives with improved swellability.
Claim 8
Dependent Claim
45 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the polymer of the adhesive layer is a mixture of cellulose ether and polyacrylic acid (or its salt) or copolymer of acrylic acid (or its salt).
Claim 9
Dependent Claim
29 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the nonadhesive layer comprises lactose or glucose or their mixture.
Claim 10
Dependent Claim
32 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 7, wherein the cellulose ether is methyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose or their mixture.
References Cited (Backward Citations)
US3249109A
Cited
US3339546A
Cited
US3444858A
Cited
US3536809A
Cited
US3696811A
Cited
US3911099A
Cited
US4039653A
Cited
US4059686A
Cited
US3972995A
Cited
FR2450618A2
Cited
DE2908847A1
Cited
US4226848A
Cited
US4250163A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-28 | 1985-03-30 | 1985-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-28 | 1989-03-30 | 1989-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-28 | 1993-03-30 | 1993-09-29 | $7700.00 | Window Closed / Lapsed |