Patent US4193915A successfully refreshed from Google Patents.
US4193915A
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Contraceptive, antibody generating, polypeptides
Assignee: Individual
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Filing: 1978-04-13
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Granted: 1980-03-18
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Expires: 1998-04-13
Abstract
Abstract Polypeptides D-Ser-Arg-Tyr-Gly-Pro-Val-Gly-Val-NH 2 , D-Ser-Arg-Ala-Tyr-Pro-Thr-Pro-Ala-Arg-Ser-Lys-Lys-NH 2 , D-Ser-Arg-Tyr-Gly-Lys-Pro-Val-Gly-Lys-Lys-Lys-Lys-NH 2 , D-Ser-Arg-Tyr-Gly-Lys-Pro-Val-Arg-Ser-Lys-Lys-NH 2 , D-Ser-Arg-Tyr-Gly-Pro-Val-NH 2 , D-Ser-Arg-Tyr-Gly-Lys-Pro-Val-Gly-Lys-Lys-Val-NH 2 , D-Ser-Arg-Leu-Pro-Gly-Pro-Ser-NH 2 , D-Ser-Arg-Val-Leu-Val-Gly-Val-NH 2 , D-Ser-Arg-Val-Leu-Pro-Val-NH 2 , D-Ser-Arg-Ala-Tyr-Pro-Thr, D-Ser-Arg-Val-Leu-Gln-Gly-Val-NH 2 , D-Ser-Arg-Ala-Tyr-Pro-Arg-Leu-Pro-Gly-Pro-NH 2 , D-Ser-Arg-Ala-Tyr-Pro-Arg-Val-Leu-Gln-Gly-Val-NH 2 , D-Ser-Arg-Ala-Tyr-Pro-Arg-Val-Leu-Pro-Val-NH 2 , are useful as contraceptives.
Inventors
- 👤 Kenneth W. McKerns
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 19:12
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/59; C07K14/665; C07K14/695; C07K14/6955; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/11; Y10S930/13
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
82 words
A compound R 1 -R 2 -R 3 and its pharmacologically acceptable salts, wherein R 1 is chosen from the group consisting of D-Ser-Arg, Ser-Arg, and -Arg, R 2 is chosen from the group consisting of Tyr-Gly-Lys-Pro-Val-Gly-Lys-Lys, Ala-Tyr-Pro-Thr-Pro-Ala-Arg-Ser-Lys, Tyr-Gly-Lys-Pro-Val-Gly-Lys-Lys-Lys, Tyr-Gly-Lys-Pro-Val-Arg-Ser-Lys, Tyr-Gly-Pro, Tyr-Gly-Pro-Val-Gly, Val-Leu-Pro, Val-Leu-Val-Gly, Ala-Tyr-Pro, Leu-Pro-Gly-Pro, Val-Leu-Gln-Gly, Ala-Tyr-Pro-Arg-Leu-Pro-Gly, Ala-Tyr-Pro-Arg-Val-Leu-Gln-Gly and Ala-Tyr-Pro-Arg-Val-Leu-Pro, and R 3 is chosen from the group consisting of Val-NH 2 , -Val, Lys-NH 2 , -Lys, -Thr, Thr-NH 2 , -Ser, Ser-NH 2 , -Pro and -Pro-NH 2 .
Claim 2
Dependent Claim
82 words
A compound R 1 -R 2 -R 3 and its pharmacologically acceptable salts, wherein R 1 is chosen from the group consisting of D-Ser-Arg, Ser-Arg, and -Arg, R 2 is chosen from the group consisting of Tyr-Gly-Lys-Pro-Val-Gly-Lys-Lys, Ala-Tyr-Pro-Thr-Pro-Ala-Arg-Ser-Lys, Tyr-Gly-Lys-Pro-Val-Gly-Lys-Lys-Lys, Tyr-Gly-Lys-Pro-Val-Arg-Ser-Lys, Tyr-Gly-Pro, Tyr-Gly-Pro-Val-Gly, Val-Leu-Pro, Val-Leu-Val-Gly, Ala-Tyr-Pro, Leu-Pro-Gly-Pro, Val-Leu-Gln-Gly, Ala-Tyr-Pro-Arg-Leu-Pro-Gly, Ala-Tyr-Pro-Arg-Val-Leu-Gln-Gly and Ala-Tyr-Pro-Arg-Val-Leu-Pro, and R 3 is chosen from the group consisting of Val-NH 2 , -Val, Lys-NH 2 , -Lys, -Thr, Thr-NH 2 , -Ser, Ser-NH 2 , -Pro and -Pro-NH 2 .
Claim 3
Dependent Claim
44 words
A compound of claim 1 comprising R 1 -Tyr-Gly-R 6 and its pharmacologically acceptable salts, wherein R 6 is chosen from the group consisting of Pro-R 4 and Pro-Val-Gly-R 4 wherein R 4 is chosen from the group consisting of -Val-NH 2 and -Val.
Claim 4
Dependent Claim
66 words
A compound of claim 2 wherein Tyr may be substituted by an amino acid chosen from the group consisting of Ala, Val, and Leu, Gly may be substituted by an amino acid chosen from the group consisting of Tyr, Leu, and Pro and Val-NH 2 may be substituted by a compound chosen from the group consisting of Pro-NH 2 , Gly, Thr and Thr-NH 2 .
Claim 5
Dependent Claim
13 words
A compound of claim 3 comprising D-Ser-Arg-Val-Leu-Pro-Val-NH 2 and its pharmacologically acceptable salts.
Claim 6
Dependent Claim
12 words
A compound of claim 3 comprising D-Ser-Arg-Ala-Tyr-Pro-Thr and its pharmacologically acceptable salts.
Claim 7
Dependent Claim
13 words
A compound of claim 3 comprising D-Ser-Arg-Ala-Tyr-Pro-Thr-NH 2 and its pharmacologically acceptable salts.
Claim 8
Dependent Claim
13 words
A compound of claim 2 comprising D-Ser-Arg-Tyr-Gly-Pro-Val-Gly-Val-NH 2 and its pharmacologically acceptable salts.
Claim 9
Dependent Claim
13 words
A compound of claim 2 comprising D-Ser-Arg-Tyr-Gly-Pro-Val-NH 2 and its pharmacologically acceptable salts.
Claim 10
Dependent Claim
30 words
A compound of claim 1 comprising R 1 -Tyr-Gly-Lys-Pro-Val-Gly-Lys-Lys-R 4 , and its pharmacologically acceptable salts wherein R 4 is chosen from the group consisting of -Val-NH 2 and -Val.
Claim 11
Dependent Claim
13 words
A compound of claim 9 comprising D-Ser-Arg-Tyr-Gly-Lys-Pro-Val-Gly-Lys-Lys-Val-NH 2 and its pharmacologically acceptable salts.
Claim 12
Dependent Claim
30 words
A compound of claim 1 comprising R 1 -Ala-Tyr-Pro-Thr-Pro-Ala-Arg-Ser-Lys-R 5 , and its pharmacologically acceptable salts wherein R 5 is chosen from the group consisting of -Lys-NH 2 and -Lys.
Claim 13
Dependent Claim
13 words
A compound of claim 11 comprising D-Ser-Arg-Ala-Tyr-Pro-Thr-Pro-Ala-Arg-Ser-Lys-Lys-NH 2 and its pharmacologically acceptable salts.
Claim 14
Dependent Claim
29 words
A compound of claim 1 comprising R 1 -Tyr-Gly-Lys-Pro-Val-Gly-Lys-Lys-Lys-R 5 and its pharmacologically acceptable salts wherein R 5 is chosen from the group consisting of -Lys-NH 2 and -Lys.
Claim 15
Dependent Claim
13 words
A compound of claim 13 comprising D-Ser-Arg-Tyr-Gly-Lys-Pro-Val-Gly-Lys-Lys-Lys-Lys-NH 2 and its pharmacologically acceptable salts.
Claim 16
Dependent Claim
30 words
A compound of claim 1 comprising R 1 -Tyr-Gly-Lys-Pro-Val-Arg-Ser-Lys-R 5 , and its pharmacologically acceptable salts wherein R 5 is chosen from the group consisting of -Lys-NH 2 and -Lys.
Claim 17
Dependent Claim
13 words
A compound of claim 15 comprising D-Ser-Arg-Tyr-Gly-Lys-Pro-Val-Arg-Ser-Lys-Lys-NH 2 and its pharmacologically acceptable salts.
Claim 18
Dependent Claim
30 words
A compound of claim 1 comprising R 1 -Val-Leu-Val-Gly-R 4 , and its pharmacologically acceptable salts, wherein R 4 is chosen from the group consisting of Val-NH 2 and -Val.
Claim 19
Dependent Claim
14 words
A compound of claim 17 comprising D-Ser-Arg-Val-Leu-Val-Gly-Val-NH 2 , and its pharmacologically acceptable salts.
Claim 20
Dependent Claim
30 words
A compound of claim 1 comprising R 1 -Leu-Pro-Gly-Pro-R 7 , and its pharmacologically acceptable salts, wherein R 7 is chosen from the group consisting of Ser-NH 2 and Ser.
Claim 21
Dependent Claim
13 words
A compound of claim 19 comprising D-Ser-Arg-Leu-Pro-Gly-Pro-Ser-NH 2 and its pharmacologically acceptable salts.
Claim 22
Dependent Claim
29 words
A compound of claim 1 comprising R 1 -Val-Leu-Gln-Gly-R 4 and its pharmacologically acceptable salts, wherein R 4 is chosen from the group consisting of Val-NH 2 and -Val.
Claim 23
Dependent Claim
13 words
A compound of claim 21 comprising D-Ser-Arg-Val-Leu-Gln-Gly-Val-NH 2 and its pharmacologically acceptable salts.
Claim 24
Dependent Claim
30 words
A compound of claim 1 comprising R 1 -Ala-Tyr-Pro-Arg-Leu-Pro-Gly-R 8 , and its pharmacologically acceptable salts, wherein R 8 is chosen from the group consisting of Pro-NH 2 and -Pro.
Claim 25
Dependent Claim
13 words
A compound of claim 23 comprising D-Ser-Arg-Ala-Tyr-Pro-Arg-Leu-Pro-Gly-Pro-NH 2 and its pharmacologically acceptable salts.
Claim 26
Dependent Claim
29 words
A compound of claim 1 comprising R 1 -Ala-Tyr-Pro-Arg-Val-Leu-Gln-Gly-R 4 and its pharmacologically acceptable salts wherein R 4 is chosen from the group consisting of Val-NH 2 and -Val.
Claim 27
Dependent Claim
13 words
A compound of claim 25 comprising D-Ser-Arg-Ala-Tyr-Pro-Arg-Val-Leu-Gln-Gly-Val-NH 2 and its pharmacologically acceptable salts.
Claim 28
Dependent Claim
30 words
A compound of claim 1 comprising R 1 -Ala-Tyr-Pro-Arg-Val-Leu-Pro-R 4 , and its pharmacologically acceptable salts wherein R 4 is chosen from the group consisting of Val-NH 2 and -Val.
Claim 29
Dependent Claim
13 words
A compound of claim 27 comprising D-Ser-Arg-Ala-Tyr-Pro-Arg-Val-Leu-Pro-Val-NH 2 and its pharmacologically acceptable salts.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-18 | 1983-09-17 | 1984-03-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-18 | 1987-09-17 | 1988-03-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-18 | 1991-09-17 | 1992-03-18 | $7700.00 | Window Closed / Lapsed |