US4086219A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nonapeptides and methods for their production
Assignee: Parke Davis and Co LLC
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Filing: 1976-12-27
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Granted: 1978-04-25
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Expires: 1996-12-27
Abstract
Abstract New nonapeptides having the formula Prot Grp-R-Trp-Ser-Tyr-R 2 -Leu-Arg-Pro-Gly-R 3 ; salts thereof; wherein R is Gln, Gln (bzl), His (bzl), Ser (bzl), Pro, Leu, Tyr (bzl), Ile, Cys (bzl) or Phe, R 2 is D-Phe, D-Ala, D-Leu, D-Trp, D-Tyr, D-Tyr (Me), D-Ser, D-Met, D-Arg, D-Val, D-His, D-Gln, D-Phs, D-Thr, D-Pro or D-Asn and R 3 is NH 2 , NH(lower alkyl) or N-(lower alkyl) 2 , methods for their production; certain peptide intermediates and their salts used in the production thereof; and the use of said nonapeptides as luteinizing hormone releasing factor antagonists.
Inventors
- 👤 Eugene Leroy Wittle
- 👤 Mildred Catherine Rebstock
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 10:47
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0821; C07K5/10; C07K5/1002; C07K5/1005; C07K5/101; C07K7/00; C07K7/04; C07K7/23; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-L-leucyl-L-tryptophyl-L-seryl-L-tyrosyl-D-asparaginyl-L-leucyl-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 2
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-L-leucyl-L-tryptophyl-L-seryl-L-tyrosyl-D-asparaginyl-L-leucyl-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 3
Dependent Claim
10 words
A compound having the name N.sup.α -t-Butoxycarbonyl-O-benzyl-L-seryl-L-tryptophyl-L-seryl-L-tyrosyl-D-seryl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 4
Dependent Claim
10 words
A compound having the name N.sup.α -t-Butoxycarbonyl-O-benzyl-L-seryl-L-tryptophyl-L-seryl-L-tyrosyl-D-seryl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 5
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-O-benzyl-L-seryl-L-tryptophyl-L-seryl-L-tyrosyl-D-phenylalanyl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 6
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-O-benzyl-L-seryl-L-tryptophyl-L-seryl-L-tyrosyl-D-phenylalanyl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 7
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-L-glutaminyl-L-tryptophyl-L-seryl-L-tyrosyl-D-phenylalanyl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 8
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-L-glutaminyl-L-tryptophyl-L-seryl-L-tyrosyl-D-phenylalanyl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 9
Dependent Claim
10 words
A compound having the name N.sup.α -t-butoxycarbonyl-O-benzyl-L-seryl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 10
Dependent Claim
10 words
A compound having the name N.sup.α -t-butoxycarbonyl-O-benzyl-L-seryl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 11
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-L-glutaminyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 12
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-L-glutaminyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 13
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-O-benzyl-L-tyrosyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-larginyl-L-prolylglycinamide and salts thereof.
Claim 14
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-O-benzyl-L-tyrosyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-larginyl-L-prolylglycinamide and salts thereof.
Claim 15
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-L-isoleucyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 16
Dependent Claim
10 words
A compound having the name N.sup.α -benzyloxycarbonyl-L-isoleucyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-glycinamide and salts thereof.
Claim 17
Dependent Claim
11 words
A compound having the name N.sup.α -p-methoxybenzyloxycarbonyl-O-benzyl-L-seryl-L-tryptophyl-L-seryl-L-tyrosyl-D-phenylalanyl-L-leucyl-L-arginyl-L-prolyl-glycinamide hydrochloride and salts thereof.
Claim 18
Dependent Claim
11 words
A compound having the name N.sup.α -p-methoxybenzyloxycarbonyl-O-benzyl-L-seryl-L-tryptophyl-L-seryl-L-tyrosyl-D-phenylalanyl-L-leucyl-L-arginyl-L-prolyl-glycinamide hydrochloride and salts thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-24 | 1981-10-24 | 1982-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-24 | 1985-10-24 | 1986-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-24 | 1989-10-24 | 1990-04-25 | $7700.00 | Window Closed / Lapsed |