Patent US4573848A successfully refreshed from Google Patents.
US4031071A
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Tetrapeptides
Assignee: Parke Davis and Co LLC
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Filing: 1976-03-01
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Granted: 1977-06-21
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Expires: 1996-03-01
Abstract
Abstract New tetrapeptides having the formula A-Ser(benzyl)-Try(benzyl)-D-Ala-Leu-R 1 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl); Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); Leu is D-Leu or L-Leu, and R 1 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.
Inventors
- 👤 Eugene Leroy Wittle
- 👤 Ernest D. Nicolaides
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:56
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; C07K5/1013; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
43 words
A tetrapeptide represented by the formula A-Ser(benzyl)-Tyr(benzyl)-D-Ala-Leu-R.sub.1 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl or p-nitrobenzyloxycarbonyl; Ser(benzyl) is L-Ser(benzyl) or D-Ser(benzyl), Tyr(benzyl) is L-Tyr(benzyl) or D-Tyr(benzyl), Leu is L-Leu or D-Leu, and R 1 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.
Claim 2
Dependent Claim
43 words
A tetrapeptide represented by the formula A-Ser(benzyl)-Tyr(benzyl)-D-Ala-Leu-R.sub.1 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl or p-nitrobenzyloxycarbonyl; Ser(benzyl) is L-Ser(benzyl) or D-Ser(benzyl), Tyr(benzyl) is L-Tyr(benzyl) or D-Tyr(benzyl), Leu is L-Leu or D-Leu, and R 1 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.
Claim 3
Dependent Claim
11 words
The compound of claim 1 having the name N.sup.α-t-butoxycarbonyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-alanyl-L-leucine methyl ester.
Claim 4
Dependent Claim
10 words
The compound of claim 1 having the name N.sup.α-t-butoxycarbonyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-alanyl-L-leucine N-ethylamide.
Claim 5
Dependent Claim
10 words
The compound of claim 1 having the name N.sup.α-t-butoxycarbonyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-alanyl-D-leucine N-ethylamide.
References Cited (Backward Citations)
US3725380A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-20 | 1980-12-20 | 1981-06-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-20 | 1984-12-20 | 1985-06-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-20 | 1988-12-20 | 1989-06-21 | $7700.00 | Window Closed / Lapsed |