US4043994A
Expired / Lapsed
US
⏱️ 0.0 years remaining
New pentapeptides and methods for their production
Assignee: Parke Davis and Co LLC
•
Filing: 1976-06-23
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Granted: 1977-08-23
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Expires: 1996-06-23
Abstract
Abstract New pentapeptides having the formula X-R-Ser-(benzyl)-Tyr(benzyl)-R 1 -Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Aze, His(benzyl) and Trp; R 1 is a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Ala, Leu and Pro and Y is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino with the priviso that the total number of amino acid units when R and R 1 are combined is three.
Inventors
- 👤 Eugene Leroy Wittle
- 👤 Ernest D. Nicolaides
- 👤 Marland Paul Hutt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 03:35
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/06; C07K7/23; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
94 words
A pentapeptide of the formula X--R--Ser(benzyl)-Tyr(benzyl)--R.sup.1 Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Aze, His(benzyl) and Trp; R 1 is a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Ala, Leu and Pro and Y is lower alkoxy, hydrazino, amino, lower alkylamino and di(lower alkyl)amino with the proviso that the total number of amino acid units when R and R 1 are combined is three.
Claim 2
Dependent Claim
94 words
A pentapeptide of the formula X--R--Ser(benzyl)-Tyr(benzyl)--R.sup.1 Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Aze, His(benzyl) and Trp; R 1 is a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Ala, Leu and Pro and Y is lower alkoxy, hydrazino, amino, lower alkylamino and di(lower alkyl)amino with the proviso that the total number of amino acid units when R and R 1 are combined is three.
Claim 3
Dependent Claim
26 words
The pentapeptides of claim 1 wherein X is t-butoxycarbonyl, R is Trp or His(benzyl), R 1 is Ala-Leu or Ala-Pro and Y is methoxy or ethylamino.
Claim 4
Dependent Claim
12 words
The pentapeptide of claim 1 having the name N.sup.α -t-butoxycarbonyl-D-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-alanyl-L-leucine methyl ester.
Claim 5
Dependent Claim
11 words
The pentapeptide of claim 1 having the name N.sup.α -t-butoxycarbonyl-D-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-alanyl-D-proline N-ethylamide.
Claim 6
Dependent Claim
11 words
The pentapeptide of claim 1 having the name N.sup.α -t-butoxycarbonyl-D-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-alanyl-L-proline N-ethylamide.
Claim 7
Dependent Claim
14 words
The pentapeptide of claim 1 having the name N.sup.α -t-butoxycarbonyl-N im -benzyl-L-histidyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-alanyl-L-leucine methyl ester.
Claim 8
Dependent Claim
13 words
The pentapeptide of claim 1 having the name N.sup.α -t-butoxycarbonyl-N im -benzyl-L-histidyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-alanyl-L-leucyl hydrazide.
References Cited (Backward Citations)
US3796697A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-22 | 1981-02-21 | 1981-08-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-22 | 1985-02-21 | 1985-08-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-22 | 1989-02-21 | 1989-08-23 | $7700.00 | Window Closed / Lapsed |