Patent US4014335A successfully refreshed from Google Patents.
US4014335A
Expired / Lapsed
US
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Ocular drug delivery device
Assignee: Alza Corp
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Filing: 1976-03-25
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Granted: 1977-03-29
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Expires: 1996-03-25
Abstract
Abstract An ocular drug dispensing device for administering a drug at a controlled and continuous dosage unit rate to the eye to produce a local or systemic physiological or pharmacological effect is comprised of a shaped body insoluble in tear fluid and comprised of a first wall, a third wall distant from the first wall, a second wall interposed between the first and third wall and extending around their peripheries for sealingly engaging the first and third wall, a reservoir defined by the inner surfaces of the walls and containing the drug or a mixture of the drug in a carrier and wherein at least one of the first and third walls is formed of an imperforate drug release rate controlling material permeable to the passage of drug or a microporous material containing in the micropores a drug release rate controlling medium permeable to the passage of drug for administering a therapeutically effective amount of drug over a prolonged period of time.
Inventors
- 👤 Randall K. Arnold
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:44
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002; A61F; A61F9/00; A61F9/0008; A61F9/0017; A61K; A61K9/00; A61K9/0012; A61K9/0048; A61K9/0051
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
144 words
An ocular device for the administration of drug comprising a three layered laminate having a pair of separate and discrete first and third walls formed of a material insoluble in tear fluid with one of the walls formed of a drug release rate controlling material permeable to the passage of drug and the other wall formed of a material impermeable to the passage of drug, a second wall interposed between the first and third walls and formed with an inwardly disposed hole with the second wall sealingly engaging the first and third walls to form a reservoir containing a drug selected from the group consisting of antibiotic, antibacterial, antiviral, antiallergenic, anti-inflammatory, miotic, anticholinesterase, mydriatic and sympathomimetic drugs, and wherein drug is administered from the device at a controlled and continuous rate by passage through the rate controlling wall over a prolonged period of time.
Claim 2
Dependent Claim
144 words
An ocular device for the administration of drug comprising a three layered laminate having a pair of separate and discrete first and third walls formed of a material insoluble in tear fluid with one of the walls formed of a drug release rate controlling material permeable to the passage of drug and the other wall formed of a material impermeable to the passage of drug, a second wall interposed between the first and third walls and formed with an inwardly disposed hole with the second wall sealingly engaging the first and third walls to form a reservoir containing a drug selected from the group consisting of antibiotic, antibacterial, antiviral, antiallergenic, anti-inflammatory, miotic, anticholinesterase, mydriatic and sympathomimetic drugs, and wherein drug is administered from the device at a controlled and continuous rate by passage through the rate controlling wall over a prolonged period of time.
Claim 3
Dependent Claim
38 words
The ocular device for the administration of drug according to claim 1 wherein the antibiotic is a member selected from the group consisting of tetracycline, chlortetracycline, bacitracin, neomycin, polymyxin, gramicidin, oxytetracycline, chloramphenicol, gentamycin, penicillin, erythomycin, and mixtures thereof.
Claim 4
Dependent Claim
31 words
The ocular system for the administration of drug according to claim 1 wherein the antibacterial is a member selected from the group consisting of sulfonamide, sulfacetamide, sulfamethizole, sulfisoxyazole, and mixtures thereof.
Claim 5
Dependent Claim
18 words
The ocular system for the administration of drug according to claim 1 wherein the antiviral drug is idoxuridine.
Claim 6
Dependent Claim
43 words
The ocular device for the administration of drug according to claim 1 wherein the anti-inflammatory drug is a member selected from the group consisting of hydrocortisone, hydrocortisone acetate, dexamethasone, dexamethasone 21-phosphate, flucoinolone, medrysone, prednisolone, methylprednisolone, prednisolone 21-phosphate, prednisolone acetate, fluoromethalone, betamethasone and triaminolone.
Claim 7
Dependent Claim
28 words
The ocular device for the administration of drug according to claim 1 wherein the sympathomimetic is a member selected from the group consisting of phenylephrine, epinephrine and hydroamphetamine.
Claim 8
Dependent Claim
33 words
The ocular device for the administration of drug according to claim 1 wherein the drug release rate controlling wall is formed of a homogenous material permeable to the passage of drug by diffusion.
Claim 9
Dependent Claim
40 words
The ocular device for the administration of drug according to claim 1 wherein the reservoir containing the drug additionally contains a carrier which carrier is more permeable to the passage of drug than is the drug release rate controlling wall.
Claim 10
Dependent Claim
55 words
The ocular device for the administration of drug according to claim 1 wherein the second wall is formed of a member selected from the group consisting of poly(vinylacetate), cross-linked poly(vinyl alcohol), cross-linked poly(vinyl butyrate), ethylene-ethylacrylate copolymer, poly(ethyl hexylacrylate), poly(vinyl chloride), poly(vinyl acetate), ethylene-vinyl acetate copolymer, plasticized ethylene-vinyl acetate copolymer, poly(vinyl ester), poly(vinyl formal), and polyamide.
Claim 11
Dependent Claim
32 words
The ocular device for the administration of drug according to claim 1 wherein the drug is mixed with a carrier selected from the group of solid, semi-solid, liquid, gel and colloidal carriers.
Claim 12
Dependent Claim
80 words
The ocular device for administering drug according to claim 1 wherein the drug is mixed with a carrier selected from the group consisting of a polysaccharide, agar, agarose, algin, sodium alginate, carrageenan, fucordan, furcellaran, laminaran, hypnea, gum arabic, gum ghatti, gum karaya, starch, gum tragacanth, guar gum, locust bean gum, quince psyllium, okra gum, pectin, dextran, amylose, amylopectin, dextrin, cellulose, methylcellulose, hydroxyalkyl cellulose wherein the alkyl contains 1 to 7 carbon atoms, sodium carboxymethylcellulose, sodium carboxyethylcellulose, ethylcellulose, and mixtures thereof.
Claim 13
Dependent Claim
36 words
The ocular device for administering drug according to claim 1 wherein the device has a geometric shape selected from the group consisting of ring, bean, elliptical, banana, rectangular, square, trapezoidal, triangular, half-circle and crescent shaped devices.
Claim 14
Dependent Claim
134 words
An ocular device for the administration of an ophthalmic drug comprising a three layered laminate having a pair of separate and discrete first and third walls formed of a material insoluble in tear fluid with one of the walls formed of a drug release rate controlling material permeable to the passage of drug and the other wall formed of a material impermeable to the passage of drug, a second wall interposed between the first and third walls and formed with an inwardly disposed hole with the second wall sealingly engaging the first and third walls to form a reservoir containing a drug selected from the group of ophthalmic drugs consisting of pilocarpine, pilocarpine and its acceptable salts, eserine salicylate, carbachol, eserine, phospholine iodide, demecarium bromide, cyclopentolate, homatropine, scopolamine, atropine, atropine sulfate, eucatropine, and tropicamide.
Claim 15
Dependent Claim
134 words
An ocular device for the administration of an ophthalmic drug comprising a three layered laminate having a pair of separate and discrete first and third walls formed of a material insoluble in tear fluid with one of the walls formed of a drug release rate controlling material permeable to the passage of drug and the other wall formed of a material impermeable to the passage of drug, a second wall interposed between the first and third walls and formed with an inwardly disposed hole with the second wall sealingly engaging the first and third walls to form a reservoir containing a drug selected from the group of ophthalmic drugs consisting of pilocarpine, pilocarpine and its acceptable salts, eserine salicylate, carbachol, eserine, phospholine iodide, demecarium bromide, cyclopentolate, homatropine, scopolamine, atropine, atropine sulfate, eucatropine, and tropicamide.
Claim 16
Dependent Claim
152 words
An ocular device for the administration of drug comprising a three layered laminate having a pair of separate and discrete first and third walls formed of a material insoluble in tear fluid with one of the walls formed of a microporous material, the pores of which contain a drug release rate controlling medium permeable to the passage of drug and the other wall formed of a material impermeable to the passage of drug, a second wall positioned between the first and third walls and formed with an inwardly disposed hole with the second wall sealingly engaging the first and third walls to form a reservoir containing a drug selected from the group consisting of antibiotic, antibacterial, antiviral, antiallergenic, anti-inflammatory, miotic, anticholinesterase, mydriatic and sympathomimetic drugs, and wherein drug is administered from the device at a controlled and continuous rate by passage through the rate controlling medium over a prolonged period of time.
Claim 17
Dependent Claim
152 words
An ocular device for the administration of drug comprising a three layered laminate having a pair of separate and discrete first and third walls formed of a material insoluble in tear fluid with one of the walls formed of a microporous material, the pores of which contain a drug release rate controlling medium permeable to the passage of drug and the other wall formed of a material impermeable to the passage of drug, a second wall positioned between the first and third walls and formed with an inwardly disposed hole with the second wall sealingly engaging the first and third walls to form a reservoir containing a drug selected from the group consisting of antibiotic, antibacterial, antiviral, antiallergenic, anti-inflammatory, miotic, anticholinesterase, mydriatic and sympathomimetic drugs, and wherein drug is administered from the device at a controlled and continuous rate by passage through the rate controlling medium over a prolonged period of time.
Claim 18
Dependent Claim
48 words
An ocular device for the administration of drug according to claim 14 wherein the drug is an ophthalmic drug selected from the group consisting of pilocarpine, pilocarpine and its acceptable salts, eserine, eserine salicylate, carbachol, phospholine iodide, demecarium bromide, cyclopentolate, homatropine, scopolamine, atropine, atropine sulfate, eucatropine and tropicamide.
Claim 19
Dependent Claim
32 words
An ocular system for the administration of drug according to claim 14 wherein the microporous wall is formed of a microporous material having a porosity of between 5 percent and 95 percent.
Claim 20
Dependent Claim
168 words
An ocular delivery device for the continuous administration of drug over a prolonged period of time comprising a sealed container shaped for insertion and placement in the eye, said container comprising a pair of first and third membrane walls spaced from each other, each formed of a material insoluble in ocular fluid with one of the membrane walls formed of a material permeable to the passage of ocular drug and the other membrane wall formed of a material substantially impermeable to the passage of drug, a second peripheral shaped wall interposed between and sealingly engaging the first and third membrane walls along their outer faced peripheries to define an integral unit and form a reservoir defined by the inner surface of the first, second and third walls, said reservoir containing ocular drug selected from the group consisting of locally and systemically acting drugs which are released therefrom at a controlled and continuous rate by passage through the release rate controlling membrane wall over a prolonged period of time.
Claim 21
Dependent Claim
168 words
An ocular delivery device for the continuous administration of drug over a prolonged period of time comprising a sealed container shaped for insertion and placement in the eye, said container comprising a pair of first and third membrane walls spaced from each other, each formed of a material insoluble in ocular fluid with one of the membrane walls formed of a material permeable to the passage of ocular drug and the other membrane wall formed of a material substantially impermeable to the passage of drug, a second peripheral shaped wall interposed between and sealingly engaging the first and third membrane walls along their outer faced peripheries to define an integral unit and form a reservoir defined by the inner surface of the first, second and third walls, said reservoir containing ocular drug selected from the group consisting of locally and systemically acting drugs which are released therefrom at a controlled and continuous rate by passage through the release rate controlling membrane wall over a prolonged period of time.
Claim 22
Dependent Claim
26 words
The ocular delivery device for the continuous administration of ocular drug according to claim 17 wherein the second wall is ring, elliptical, oval or annular shaped.
Claim 23
Dependent Claim
35 words
The ocular delivery device for the continuous administration of ocular drug according to claim 17 wherein the device is longer than wide and is designed for insertion and placement in the cul-de-sac of the eye.
Claim 24
Dependent Claim
38 words
An ocular delivery device for the continuous administration of ocular drug according to claim 17 wherein the drug is a member selected from the group consisting of antibiotic, antibacterial, antiviral, antiallergenic, anti-inflammatory, miotic, anticholinesterase, mydriatic and sympathomimetic drugs.
Claim 25
Dependent Claim
47 words
An ocular delivery device for the continuous administration of drug according to claim 17 wherein the drug is a member selected from the group consisting of phenylephrine, epinephrine, pilocarpine, pilocarpine and its acceptable salts, eserine, idoxuridine, tetracycline, neomycin, penicillin, erythromycin, scopolamine, atropine, physostigmine, hydrocortisone, prednisolone, and sulfisoxazole.
Claim 26
Dependent Claim
48 words
An ocular delivery device for the continuous administration of drug according to claim 17 wherein the membrane wall is formed of a material permeable to the passage of ocular drug by diffusion selected from the group consisting of ethylene-vinyl acetate copolymer, plasticized ethylene-vinyl acetate copolymer, poly(dimethylsiloxane) and poly(ethylene).
Claim 27
Dependent Claim
54 words
An ocular delivery system for the continuous administration of drug according to claim 17 wherein the device is sized, shaped and adapted for insertion and placement into a human eye and has a length of 4 to 20 millimeters, a width of 1 to 15 millimeters and a thickness of 0.1 to 4 millimeters.
Claim 28
Dependent Claim
36 words
An ocular delivery device for the continuous administration of drug according to claim 17 wherein the reservoir has a diameter of 1.2 to 14.8 millimeters and contains from 1 microgram to 100 milligrams of ocular drug.
Claim 29
Dependent Claim
181 words
An ocular delivery device for the continuous administration of drug comprising a closed container shaped and sized for insertion and placement in the eye, said container comprising a pair of first and third walls spaced from each other, each formed of a material insoluble in ocular fluid with one of the walls formed of a microporous polymeric material capable of housing in its pores a drug release rate controlling medium permeable to the passage of drug and the other wall formed of a material substantially impermeable to the passage of drug, a second peripheral shaped wall positioned between and sealingly engaging the first and third walls along their marginal faced peripheries to define an integral unit and form a reservoir defined by the inner surface of the first, second and third walls, said reservoir containing an ocular drug selected from the group of drugs that give physiologic and pharmacologic beneficial effects, which is released from the device at a controlled and continuous rate by passage through the release rate controlling medium housed in the pores over a prolonged period of time.
Claim 30
Dependent Claim
181 words
An ocular delivery device for the continuous administration of drug comprising a closed container shaped and sized for insertion and placement in the eye, said container comprising a pair of first and third walls spaced from each other, each formed of a material insoluble in ocular fluid with one of the walls formed of a microporous polymeric material capable of housing in its pores a drug release rate controlling medium permeable to the passage of drug and the other wall formed of a material substantially impermeable to the passage of drug, a second peripheral shaped wall positioned between and sealingly engaging the first and third walls along their marginal faced peripheries to define an integral unit and form a reservoir defined by the inner surface of the first, second and third walls, said reservoir containing an ocular drug selected from the group of drugs that give physiologic and pharmacologic beneficial effects, which is released from the device at a controlled and continuous rate by passage through the release rate controlling medium housed in the pores over a prolonged period of time.
Claim 31
Dependent Claim
47 words
The ocular delivery device for the continuous administration of drug according to claim 25 wherein the drug has limited solubility in the medium housed in the pores with the drug selected from the group consisting of mydriatic, parasympatholytic, parasympathomimetic, anticholinesterase, adrenergic, anti-inflammatory, anti-infective, antifungal and antiviral drugs.
Claim 32
Dependent Claim
24 words
The ocular delivery device for the continuous administration of drug according to claim 25 wherein the medium housed in the micropores is eye fluid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-28 | 1980-09-27 | 1981-03-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-28 | 1984-09-27 | 1985-03-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-28 | 1988-09-27 | 1989-03-29 | $7700.00 | Window Closed / Lapsed |