Patent EP0309241A2 successfully refreshed from Google Patents.
EP0309241A2
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Inductive collagen-based bone repair preparations
Assignee: Collagen Aesthetics Inc
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Filing: 1988-09-22
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Granted: —
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Expires: 2008-09-22
Abstract
Abstract An improved process for the preparation of mineral/collagen/OF (osteogenic factor) inductive implants for bone repair utilizes drying, under ambient pressure conditions, a suspension of 75-95% mineral particles, 5-25% collagen, and an effective amount of OF, such as 0.5-4% partially purified OFE or its equivalent wherein the concentration of collagen in the suspension subjected to drying is 30-100 mg/ml. The resulting implants are improved. They are homogeneous in composition and have a high compressive modulus as well as containing OF in a biologically active and available form.
Inventors
- 👤 George Chu
- 👤 Ranga Nathan
- 👤 Saeid Seyedin
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 23:08
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/36; A61L27/3641; A61L27/3645; A61L27/365; A61L27/40; A61L27/44; A61L27/46; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A61K; A61K38/00; A61L2430/00; A61L2430/02; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
110 words
A process for preparing a hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate wherein the composition comprises an osteoinductively effective amount of a protein osteoinductive factor (OF), which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host, and a carrier having components which consist essentially of mineral constituting 60-98% and collagen constituting 2-40% of the composition, which process comprises: (a) preparing a uniform suspension in water of the collagen, mineral, and OF components of the composition so that the concentration of collagen in the suspension is 30-100 mg/ml; and (b) subjecting the suspension to controlled drying under ambient pressure to obtain a rigid solid.
Claim 2
Dependent Claim
110 words
A process for preparing a hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate wherein the composition comprises an osteoinductively effective amount of a protein osteoinductive factor (OF), which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host, and a carrier having components which consist essentially of mineral constituting 60-98% and collagen constituting 2-40% of the composition, which process comprises: (a) preparing a uniform suspension in water of the collagen, mineral, and OF components of the composition so that the concentration of collagen in the suspension is 30-100 mg/ml; and (b) subjecting the suspension to controlled drying under ambient pressure to obtain a rigid solid.
Claim 3
Dependent Claim
22 words
The process of claim 1 wherein the drying is continued until the solid has a compressive modulus of at least 20 N/cm².
Claim 4
Dependent Claim
18 words
A process of claim 1 or claim 2, which further includes heat curing of the product of (b).
Claim 5
Dependent Claim
16 words
The process of claim 3 wherein the heat curing is conducted at 50-120°C for 4-168 hours.
Claim 6
Dependent Claim
45 words
The process of any one of the preceding claims wherein the suspension of (a) is prepared by mixing a dilute solution of OF with mineral particles, drying the mixture, and mixing the dried mixture with reconstituted atelopeptide fibrillar collagen suspension containing 30-100 mg/ml of collagen.
Claim 7
Dependent Claim
51 words
A process of any one of claims 1 to 4 wherein the suspension of (a) is prepared by adding a solution of OF to collagen in solution, precipitating the collagen and OF, resuspending the precipitate to a collagen concentration of 10-100 mg/ml, and then mixing the resulting suspension with mineral particles.
Claim 8
Dependent Claim
67 words
A hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate, which consists essentially of 60-98% mineral particles; 2-40% of atelopeptide hypoimmunogenic collagen; and an effective amount of an OF preparation, wherein the implant is a porous rigid solid of compressive modulus greater than 20 N/cm², is homogeneous with respect to its components, and wherein the OF is in a biologically active and available form.
Claim 9
Dependent Claim
67 words
A hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate, which consists essentially of 60-98% mineral particles; 2-40% of atelopeptide hypoimmunogenic collagen; and an effective amount of an OF preparation, wherein the implant is a porous rigid solid of compressive modulus greater than 20 N/cm², is homogeneous with respect to its components, and wherein the OF is in a biologically active and available form.
Claim 10
Dependent Claim
20 words
The composition of claim 7,wherein the effective amount of OF preparation is 0.5-4% of partially purified OF or its equivalent.
Claim 11
Dependent Claim
51 words
A hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate which comprises an osteoinductively effective amount of a protein osteoinductive factor (OF) derived from bone, which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host, said composition containing at least 75% by weight of mineral carrier.
Claim 12
Dependent Claim
51 words
A hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate which comprises an osteoinductively effective amount of a protein osteoinductive factor (OF) derived from bone, which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host, said composition containing at least 75% by weight of mineral carrier.
Claim 13
Dependent Claim
158 words
The hypoimmunogenic composition of claim 9 selected from the group consisting of (a) a composition which is 87.5% bone collagen powder and 10% non-fibrillar collagen, and wherein the amount of OF corresponds to that obtained by including between about 2.5% by weight of the implant as partially purified OF; (b) a composition which is 85-95% mineral carrier, 5-15% atelopeptide collagen, and wherein the amount of OF corresponds to that obtained by including between about 0.5% and 4% by weight of the implant of partially purified OF; (c) a composition which is 87.5% TCP/HA mixture and 10% non-fibrillar collagen, and wherein the amount of OF corresponds to that obtained by including about 2.5% by weight of the implant as partially purified OF; and (d) a composition which is 91.5% TCP/HA mixture and 6% reconstituted fibrillar collagen, and wherein the amount of OF corresponds to that obtained by including about 2.5% by weight of the implant as partially purified OF.
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