US7623908B2
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US
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Nonlinear interferometric vibrational imaging
Assignee: University of Illinois System
•
Filing: 2003-11-19
•
Granted: 2009-11-24
•
Expires: 2023-11-19
Abstract
Abstract A method of examining a sample, which includes: exposing a reference to a first set of electromagnetic radiation, to form a second set of electromagnetic radiation scattered from the reference; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; and interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation. The first set and the third set of electromagnetic radiation are generated from a source; at least a portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the fourth set of electromagnetic radiation is of a frequency different from that of the third set of electromagnetic radiation.
Inventors
- 👤 Stephen A. Boppart
- 👤 Daniel L. Marks
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 02:15
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/47; G01N21/4795; G01J; G01J3/00; G01J3/28; G01J3/44; G01N21/62; G01N21/63; G01N21/65; B; B33; B33Y; B33Y80/00; G01N2021/653; G01N2021/656
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
168 words
A method of examining a sample, comprising: exposing a non-linear reference medium to a first set of electromagnetic radiation generated in an interferometric system to form a second set of electromagnetic radiation scattered from the non-linear reference medium; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; and interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation; and detecting fourth photos in the fourth set of electromagnetic radiation; wherein the detecting comprises interfering; wherein the fourth photons are anti-Stokes photons or Stokes photons; wherein the first set and the third set of electromagnetic radiation are generated from a source; at least a portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the fourth set of electromagnetic radiation is of a frequency different from that of the third set of electromagnetic radiation.
Claim 2
Independent Claim
168 words
A method of examining a sample, comprising: exposing a non-linear reference medium to a first set of electromagnetic radiation generated in an interferometric system to form a second set of electromagnetic radiation scattered from the non-linear reference medium; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; and interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation; and detecting fourth photos in the fourth set of electromagnetic radiation; wherein the detecting comprises interfering; wherein the fourth photons are anti-Stokes photons or Stokes photons; wherein the first set and the third set of electromagnetic radiation are generated from a source; at least a portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the fourth set of electromagnetic radiation is of a frequency different from that of the third set of electromagnetic radiation.
Claim 3
Dependent Claim
13 words
The method of claim 1 , wherein the fourth photons are anti-Stokes photons.
Claim 4
Dependent Claim
13 words
The method of claim 1 , wherein the fourth photons are Stokes photons.
Claim 5
Independent Claim
168 words
A method of forming an image of a sample, comprising: exposing a non-linear reference medium to a first set of electromagnetic radiation generated in an interferometric system to form a second set of electromagnetic radiation scattered from the non-linear reference medium; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; forming a digital data set corresponding to the sample; and converting the data set into an image; wherein the forming of the data set comprises interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation; the first set and the third set of electromagnetic radiation are generated from a source; at least a portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the fourth set of electromagnetic radiation is of a frequency different from that of the third set of electromagnetic radiation.
Claim 6
Independent Claim
168 words
A method of forming an image of a sample, comprising: exposing a non-linear reference medium to a first set of electromagnetic radiation generated in an interferometric system to form a second set of electromagnetic radiation scattered from the non-linear reference medium; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; forming a digital data set corresponding to the sample; and converting the data set into an image; wherein the forming of the data set comprises interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation; the first set and the third set of electromagnetic radiation are generated from a source; at least a portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the fourth set of electromagnetic radiation is of a frequency different from that of the third set of electromagnetic radiation.
Claim 7
Dependent Claim
13 words
The method of claim 4 , wherein the fourth photons are anti-Stokes photons.
Claim 8
Dependent Claim
20 words
The method of claim 1 , wherein the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light.
Claim 9
Dependent Claim
20 words
The method of claim 4 , wherein the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light.
Claim 10
Dependent Claim
17 words
The method of claim 1 , wherein the examining of the sample is by optical coherence tomography.
Claim 11
Dependent Claim
18 words
The method of claim 4 , wherein the forming of the data set is by optical coherence tomography.
Claim 12
Dependent Claim
25 words
The method of claim 1 , wherein the sample is selected from the group consisting of a tissue sample, a single cell, and a patient.
Claim 13
Dependent Claim
25 words
The method of claim 4 , wherein the sample is selected from the group consisting of a tissue sample, a single cell, and a patient.
Claim 14
Dependent Claim
13 words
The method of claim 10 , wherein the sample is a human patient.
Claim 15
Dependent Claim
13 words
The method of claim 11 , wherein the sample is a human patient.
Claim 16
Dependent Claim
85 words
In a method of forming an image using an optical coherence tomography, apparatus, the method including exposing a sample or patient to electromagnetic radiation, collecting scattered electromagnetic radiation, and forming an image from the collected electromagnetic radiation including interfering the collected electromagnetic radiation with reference electromagnetic radiation, the improvement comprising the reference electromagnetic radiation being scattered from a non-linear reference sample, and the wavelength of the collected electromagnetic radiation being different from that of the electromagnetic radiation that the sample or patient is exposed to.
Claim 17
Dependent Claim
85 words
In a method of forming an image using an optical coherence tomography, apparatus, the method including exposing a sample or patient to electromagnetic radiation, collecting scattered electromagnetic radiation, and forming an image from the collected electromagnetic radiation including interfering the collected electromagnetic radiation with reference electromagnetic radiation, the improvement comprising the reference electromagnetic radiation being scattered from a non-linear reference sample, and the wavelength of the collected electromagnetic radiation being different from that of the electromagnetic radiation that the sample or patient is exposed to.
Claim 18
Dependent Claim
62 words
In an optical coherence tomography device, including an electromagnetic radiation source for generating reference electromagnetic radiation and sample electromagnetic radiation, an optical delay line, a scanner, and a electromagnetic radiation detector, the improvement comprising a reference holder and optics adapted for exposing the reference electromagnetic radiation to a non-linear reference medium before interfering the reference electromagnetic radiation with the sample electromagnetic radiation.
Claim 19
Dependent Claim
62 words
In an optical coherence tomography device, including an electromagnetic radiation source for generating reference electromagnetic radiation and sample electromagnetic radiation, an optical delay line, a scanner, and a electromagnetic radiation detector, the improvement comprising a reference holder and optics adapted for exposing the reference electromagnetic radiation to a non-linear reference medium before interfering the reference electromagnetic radiation with the sample electromagnetic radiation.
Claim 20
Independent Claim
67 words
A device for examining a sample, comprising: an oscillator, a reference generator, including non-linear reference medium, a optically coupled to the oscillator, a sample illuminator, optically coupled to the oscillator, an interferometric demodulator, optically coupled to the reference generator and the sample illuminator, a recorder, coupled to the demodulator, and a frequency-selecting element that ensures that the light that illuminates the sample is excluded from the modulator.
Claim 21
Independent Claim
67 words
A device for examining a sample, comprising: an oscillator, a reference generator, including non-linear reference medium, a optically coupled to the oscillator, a sample illuminator, optically coupled to the oscillator, an interferometric demodulator, optically coupled to the reference generator and the sample illuminator, a recorder, coupled to the demodulator, and a frequency-selecting element that ensures that the light that illuminates the sample is excluded from the modulator.
Claim 22
Dependent Claim
12 words
The device of claim 16 , wherein the oscillator comprises a laser.
Claim 23
Dependent Claim
17 words
The device of claim 17 , wherein the oscillator further comprises a pulse shaper or a chirper.
Claim 24
Dependent Claim
19 words
The device of claim 16 , further comprising a scanner for scanning a sample, coupled to the sample illuminator.
Claim 25
Independent Claim
119 words
A method of examining a sample, comprising: exposing sample to a first set of electromagnetic radiation generated in an interferometric system to form a second set of electromagnetic radiation non-linearly scattered from the sample; and interfering the second set of electromagnetic radiation with a third set of electromagnetic radiation; wherein the third set of electromagnetic radiation is coherent with the first set of electromagnetic radiation; at least a first portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the third set of electromagnetic radiation is of the same frequency as the first portion of the second set of electromagnetic radiation.
Claim 26
Independent Claim
119 words
A method of examining a sample, comprising: exposing sample to a first set of electromagnetic radiation generated in an interferometric system to form a second set of electromagnetic radiation non-linearly scattered from the sample; and interfering the second set of electromagnetic radiation with a third set of electromagnetic radiation; wherein the third set of electromagnetic radiation is coherent with the first set of electromagnetic radiation; at least a first portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the third set of electromagnetic radiation is of the same frequency as the first portion of the second set of electromagnetic radiation.
Claim 27
Dependent Claim
24 words
The method of claim 20 , further comprising detecting second photons in the second set of electromagnetic radiation; wherein the detecting comprises the interfering.
Claim 28
Dependent Claim
13 words
The method of claim 21 , wherein the second photons are anti-Stokes photons.
Claim 29
Independent Claim
146 words
A method of forming an image of a sample, comprising: exposing a sample to a first set of electromagnetic radiation generated in an interferometric system to form a second set of electromagnetic radiation non-linearly scattered from the sample; forming a digital data set corresponding to the sample; and converting the data set into an image; wherein the forming of the image comprises interfering the second set of electromagnetic radiation and a third set of electromagnetic radiation; wherein the third set of electromagnetic radiation is phase-coherent with the first set of electromagnetic radiation; at least a first portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the third set of electromagnetic radiation is of the same frequency as the first portion of the second set of electromagnetic radiation.
Claim 30
Independent Claim
146 words
A method of forming an image of a sample, comprising: exposing a sample to a first set of electromagnetic radiation generated in an interferometric system to form a second set of electromagnetic radiation non-linearly scattered from the sample; forming a digital data set corresponding to the sample; and converting the data set into an image; wherein the forming of the image comprises interfering the second set of electromagnetic radiation and a third set of electromagnetic radiation; wherein the third set of electromagnetic radiation is phase-coherent with the first set of electromagnetic radiation; at least a first portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the third set of electromagnetic radiation is of the same frequency as the first portion of the second set of electromagnetic radiation.
Claim 31
Dependent Claim
33 words
The method of claim 23 , further comprising detecting second photons in the second set of electromagnetic radiation; wherein the detecting comprises the interfering, and the forming of the image comprises the detecting.
Claim 32
Dependent Claim
13 words
The method of claim 23 , wherein the second photons are anti-Stokes photons.
Claim 33
Dependent Claim
13 words
The method of claim 23 , wherein the second photons are Stokes photons.
Claim 34
Dependent Claim
20 words
The method of claim 20 , wherein the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light.
Claim 35
Dependent Claim
20 words
The method of claim 23 , wherein the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light.
Claim 36
Dependent Claim
17 words
The method of claim 20 , wherein the examining of the sample is by optical coherence tomography.
Claim 37
Dependent Claim
17 words
The method of claim 23 , wherein the forming of the image is by optical coherence tomography.
Claim 38
Dependent Claim
25 words
The method of claim 20 , wherein the sample is selected from the group consisting of a tissue sample, a single cell, and a patient.
Claim 39
Dependent Claim
25 words
The method of claim 23 , wherein the sample is selected from the group consisting of a tissue sample, a single cell, and a patient.
Claim 40
Dependent Claim
13 words
The method of claim 31 , wherein the sample is a human patient.
Claim 41
Dependent Claim
13 words
The method of claim 32 , wherein the sample is a human patient.
Claim 42
Independent Claim
142 words
A method of examining a sample, comprising: exposing a non-linear reference medium to a first set of electromagnetic radiation generated in an interferometric system to form a second set of electromagnetic radiation inelastically scattered from the non-linear reference; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; and interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation; wherein the first set and the third set of electromagnetic radiation are generated from a source; at least a portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the fourth set of electromagnetic radiation is of a frequency different from that of the third set of electromagnetic radiation.
Claim 43
Independent Claim
142 words
A method of examining a sample, comprising: exposing a non-linear reference medium to a first set of electromagnetic radiation generated in an interferometric system to form a second set of electromagnetic radiation inelastically scattered from the non-linear reference; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; and interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation; wherein the first set and the third set of electromagnetic radiation are generated from a source; at least a portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the fourth set of electromagnetic radiation is of a frequency different from that of the third set of electromagnetic radiation.
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