US5665382A
Expired / Lapsed
US
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Methods for the preparation of pharmaceutically active agents for in vivo delivery
Assignee: Abraxis Bioscience LLC
•
Filing: 1995-06-07
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Granted: 1997-09-09
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Expires: 2015-06-07
Abstract
Abstract In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
Inventors
- 👤 Mark W. Grinstaff
- 👤 Patrick Soon-Shiong
- 👤 Michael Wong
- 👤 Paul A. Sandford
- 👤 Kenneth S. Suslick
- 👤 Neil P. Desai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:24
CPC Classifications
A; A23; A23L; A23L33/00; A23L33/40; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6921; A61K47/6925; A61K47/6927; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/12; A61K49/126; A61K49/18; A61K49/1818; A61K49/1821; A61K49/1824; A61K49/1827; A61K49/1851; A61K49/1863; A61K49/22; A61K49/222; A61K49/223; A61K49/226; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5052; A61K9/51; A61K9/5107; A61K9/513; A61K9/5138; A61K9/5146; A61K9/5161; A61K9/5169; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
81 words
A method for the preparation of pharmaceutically active agents for in vivo delivery, said method comprising subjecting aqueous medium containing biocompatible material capable of being crosslinked by disulfide bonds and a pharmaceutically active agent to high intensity ultrasound conditions for a time sufficient to promote crosslinking of said biocompatible material by disulfide bonds; wherein said pharmaceutically active agent issubstantially completely contained within a polymeric shell, and wherein the largest cross-sectional dimension of said shell is no greater than about 10 microns.
Claim 2
Independent Claim
81 words
A method for the preparation of pharmaceutically active agents for in vivo delivery, said method comprising subjecting aqueous medium containing biocompatible material capable of being crosslinked by disulfide bonds and a pharmaceutically active agent to high intensity ultrasound conditions for a time sufficient to promote crosslinking of said biocompatible material by disulfide bonds; wherein said pharmaceutically active agent issubstantially completely contained within a polymeric shell, and wherein the largest cross-sectional dimension of said shell is no greater than about 10 microns.
Claim 3
Dependent Claim
37 words
The method according to claim 1, wherein said biocompatible material is a naturally occurring polymer, a synthetic polymer, or a combination thereof, wherein said polymer, prior to crosslinking, has covalently attached thereto sulfhydryl groups or disulfide linkages.
Claim 4
Dependent Claim
51 words
The method according to claim 2, wherein said naturally occurring polymer is selected from proteins containing sulfhydryl groups and/or disulfide groups, polypeptides containing sulfhydryl groups and/or disulfide groups, lipids containing sulfhydryl groups and/or disulfide groups, polynucleic acids containing sulfhydryl groups and/or disulfide groups, or polysaccharides containing sulfhydryl groups and/or disulfide groups.
Claim 5
Dependent Claim
30 words
The method according to claim 3, wherein said protein is selected from hemoglobin, myoglobin, albumin, insulin, lysozyme, immunoglobulins, α-2-macroglobulin, fibronectin, vitronectin, fibrinogen, or combinations of any two or more thereof.
Claim 6
Dependent Claim
11 words
The method according to claim 4, wherein said protein is albumin.
Claim 7
Dependent Claim
11 words
The method according to claim 4, wherein said protein is hemoglobin.
Claim 8
Dependent Claim
16 words
The method according to claim 4, wherein said protein is a combination of albumin and hemoglobin.
Claim 9
Dependent Claim
19 words
The method according to claim 1, wherein said pharmaceutically active agent is selected from a solid, liquid, or gas.
Claim 10
Dependent Claim
46 words
The method according to claim 1, wherein said pharmaceutically active agent is selected from analgesic agents, anesthetic agents, anti-asthmatic agents, antibiotics, anti-depressant agents, anti-diabetic agents, anti-fungal agents, anti-hypertensive agents, anti-inflammatory agents, anti-neoplastic agents, anxiolytic agents, enzymatically active agents, immunostimulating agents, immunosuppressive agents, or physiologically active gases.
Claim 11
Dependent Claim
21 words
The method according to claim 9, wherein said analgesic agent is selected from acetaminophen, aspirin, ibuprofen, or morphine and derivatives thereof.
Claim 12
Dependent Claim
50 words
A method for the delivery of a pharmaceutically agent to a subject in need thereof, said method comprising administering to said subject the articles prepared by the method of claim 1 by oral, intravenous, subcutaneous, intraperitoneal, intrathecal, intramuscular, intracranial, inhalational, topical, transdermal, suppository (rectal), or pessary (vaginal) routes of administration.
References Cited (Backward Citations)
US3536074A
Cited
US3959457A
Cited
US4073943A
Cited
US4001401A
Cited
US4061736A
Cited
US4001200A
Cited
US4053590A
Cited
US4226248A
Cited
US4247406A
Cited
US4534899A
Cited
US4572203A
Cited
US4718433A
Cited
WO1985000011A1
Cited
EP0129619A1
Cited
US4671954A
Cited
US4789550A
Cited
US4598064A
Cited
US4600531A
Cited
US4639364A
Cited
EP0190050A2
Cited
US4584130A
Cited
EP0213303A2
Cited
WO1987001055A1
Cited
WO1988001506A1
Cited
WO1988007365A2
Cited
EP0295941A2
Cited
EP0307863A1
Cited
WO1989003674A1
Cited
WO1989003693A1
Cited
US4844882A
Cited
US4929446A
Cited
US5171755A
Cited
WO1990001953A1
Cited
US4951673A
Cited
EP0361677A1
Cited
EP0391518A2
Cited
WO1990013780A1
Cited
WO1990013285A1
Cited
US5114703A
Cited
US5116599A
Cited
WO1991001759A1
Cited
EP0418153A1
Cited
US5250283A
Cited
WO1991015753A1
Cited
WO1991015947A1
Cited
US5059699A
Cited
US5110606A
Cited
US5318767A
Cited
US5143716A
Cited
WO1992018165A2
Cited
US5362478A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-09-08 | 2001-03-10 | 2001-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-09-08 | 2005-03-10 | 2005-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-09-08 | 2009-03-10 | 2009-09-09 | $7700.00 | Window Closed / Lapsed |