US4001200A
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Novel polymerized, cross-linked, stromal-free hemoglobin
Assignee: QUEST BLOOD SUBSTITUTE Inc
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Filing: 1975-02-27
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Granted: 1977-01-04
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Expires: 1995-02-27
Abstract
Abstract This invention concerns polymerized, cross-linked, stromal-free hemoglobin useful as a blood substitute for carrying oxygen to tissues and organs, as a blood plasma expander and for supplying oxygen to oxygen-requiring environments.
Inventors
- 👤 Pieter Bonsen
- 👤 Myron B. Laver
- 👤 Kent C. Morris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 05:59
CPC Classifications
C; C08; C08H; C08H1/00; C07; C07K; C07K14/00; C07K14/795; C07K14/805; A; A61; A61K; A61K38/00; A61M; A61M1/00; A61M1/36; A61M1/3693; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0429; A61M2202/0433; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/105831
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
54 words
Polymerized, cross-linked, stromal-free hemoglobin, soluble in aqueous and physiological fluids, capable of reversibly binding a ligand, having a molecular weight of 64,000 to 1,000,000 and the formula poly(Hb) n wherein Hb is a member selected from the group consisting of a stromal-free monomer, dimer, trimer and tetramer hemoglobin, and n is 4 to 60.
Claim 2
Dependent Claim
54 words
Polymerized, cross-linked, stromal-free hemoglobin, soluble in aqueous and physiological fluids, capable of reversibly binding a ligand, having a molecular weight of 64,000 to 1,000,000 and the formula poly(Hb) n wherein Hb is a member selected from the group consisting of a stromal-free monomer, dimer, trimer and tetramer hemoglobin, and n is 4 to 60.
Claim 3
Dependent Claim
12 words
The polymerized hemoglobin according to claim 1 wherein the hemoglobin is deoxyhemoglobin.
Claim 4
Dependent Claim
13 words
The polymerized hemoglobin according to claim 1 wherein the hemoglobin is liganded hemoglobin.
Claim 5
Dependent Claim
34 words
The polymerized hemoglobin according to claim 1 wherein the polymerized hemoglobin is soluble in physiological fluids, has an oxygen capacity close to 100%, and an intrinsic viscosity of 0.04 to 0.16 deciliters per gram.
Claim 6
Dependent Claim
34 words
The polymerized hemoglobin according to claim 1 wherein the polymerized hemoglobin has a partial pressure at half-saturation, P 50 , or 2.5 mm Hg to 120 mm Hg at 37° C and neutral pH.
Claim 7
Dependent Claim
30 words
The polymerized, cross-linked, stromal-free hemoglobin according to claim 1 wherein the hemoglobin is cross-linked with a member selected from the group consisting of gluturaldehyde, divinylsulfone, hexamethylene diisocyanate and butadiene diepoxide.
References Cited (Backward Citations)
US3057782A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-04 | 1980-07-05 | 1981-01-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-04 | 1984-07-05 | 1985-01-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-04 | 1988-07-05 | 1989-01-04 | $7700.00 | Window Closed / Lapsed |