US6428811B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
Assignee: Rice University
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Filing: 2000-07-14
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Granted: 2002-08-06
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Expires: 2020-07-14
Abstract
Abstract A thermally sensitive polymer-particle composite that absorbs electromagnetic radiation, and uses the absorbed energy to trigger the delivery of a chemical is disclosed. Metal nanoshells are nanoparticulate materials that are suitable for use in the present composites and can be made according to a process that includes optically tuning or tailoring their maximum optical absorption to any desired wavelength primarily by altering the ratio of the core diameter to the shell thickness. Preferred nanoshells are selected that strongly absorb light in the near-infrared and thus produce heat. These nanoshells are combined with a temperature-sensitive material to provide an implantable or injectable material for modulated drug delivery via external exposure to near-IR light. This invention provides a means to improve the quality of life for persons requiring multiple injections of a drug, such as diabetes mellitus patients.
Inventors
- 👤 Jennifer L. West
- 👤 Scott R. Sershen
- 👤 Nancy J. Halas
- 👤 Steven J. Oldenburg
- 👤 Richard D. Averitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 02:22
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6903; A61K41/00; A61K41/0028; A61K41/0042; A61K47/6921; A61K47/6923; B; B01; B01J; B01J13/00; B01J13/02; B22; B22F; B22F1/00; B22F1/05; B22F1/054; B22F1/18; B82; B82Y; B82Y15/00; B82Y30/00; B82Y5/00; C; C08; C08K; C08K9/00; C08K9/02; C09; C09C; C09C1/00; C09C1/28; C09C1/30; C09C1/3045; C09C1/3054; C09C1/3081; C09C1/309; C09K; C09K3/00; G; G02; G02F; G02F1/00; G02F1/35; G02F1/355; G21; G21K; G21K1/00; G21K1/10; C01; C01P; C01P2002/00; C01P2002/80; C01P2002/82; C01P2002/84; C01P2004/00; C01P2004/01; C01P2004/04; C01P2004/10; C01P2004/12; C01P2004/30; C01P2004/32; C01P2004/38; C01P2004/50; C01P2004/54; C01P2004/60; C01P2004/61; C01P2004/62; C01P2004/64; C01P2004/80; C01P2006/00; C01P2006/22; C01P2006/32; C01P2006/33; C01P2006/40; C01P2006/60; G01; G01N; G01N21/00; G01N21/62; G01N21/63; G01N21/65; G01N21/658; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2991
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
57 words
A composition for modulated delivery of a chemical to a desired location, said composition comprising: a plurality of optically heatable particles capable of converting incident radiation into heat energy when said particles are irradiated with electromagnetic radiation; and a medium, said medium containing the chemical and comprising a thermally responsive material in thermal contact with said particles.
Claim 2
Dependent Claim
57 words
A composition for modulated delivery of a chemical to a desired location, said composition comprising: a plurality of optically heatable particles capable of converting incident radiation into heat energy when said particles are irradiated with electromagnetic radiation; and a medium, said medium containing the chemical and comprising a thermally responsive material in thermal contact with said particles.
Claim 3
Dependent Claim
55 words
The composition according to claim 1 wherein said particles each comprise: a non-conducting core, a metal shell adhering to said core and, a defined core radius:shell thickness ratio, optionally, a molecular linkage between said shell and said core, and said particles having a defined wavelength absorbance maximum when said particle is irradiated with electromagnetic radiation.
Claim 4
Dependent Claim
22 words
The composition according to claim 2 wherein said core has an independently defined diameter and said shell has an independently defined thickness.
Claim 5
Dependent Claim
21 words
The composition of claim 1 wherein said particles have a wavelength absorbance maximum between about 300 nm and about 20 μm.
Claim 6
Dependent Claim
15 words
The composition of claim 1 wherein said thermally responsive material comprises at least one polymer.
Claim 7
Dependent Claim
18 words
The composition of claim 5 wherein said at least one polymer is a copolymer of N-isopropylacrylamide and acrylamide.
Claim 8
Dependent Claim
11 words
The composition of claim 1 wherein said medium is a hydrogel.
Claim 9
Dependent Claim
13 words
The composition of claim 1 wherein said medium comprises at least two layers.
Claim 10
Dependent Claim
16 words
The composition of claim 8 wherein said particles are embedded in at least one said layer.
Claim 11
Dependent Claim
20 words
The composition of claim 1 wherein said defined wavelength absorbance maximum is in the near-infrared range of the electromagnetic spectrum.
Claim 12
Dependent Claim
16 words
The composition of claim 1 wherein said particles and said thermally responsive medium together form microparticulates.
Claim 13
Dependent Claim
18 words
The composition of claim 1 in the form of a desiccated polymer-particle composite capable of forming a hydrogel.
Claim 14
Dependent Claim
67 words
The composition of claim 1 further comprising at least one therapeutic agent releasably contained in said medium such that when the temperature of said medium or portion thereof is at a first temperature said agent is retained, and when said medium or a portion thereof is at a second temperature higher than said first temperature, at least a portion of said agent is released from said medium.
Claim 15
Dependent Claim
31 words
The composition of claim 13 wherein said first temperature is approximately normal body temperature of said subject and said second temperature is about 1-20° C. higher than said normal body temperature.
Claim 16
Dependent Claim
27 words
The composition of claim 13 wherein said thermally responsive material is substantially solid at said first temperature and undergoes a reversible phase transition above said second temperature.
Claim 17
Dependent Claim
15 words
The composition of claim 13 wherein said agent is contained in said thermally responsive medium.
Claim 18
Independent Claim
87 words
A system for modulated in vivo delivery of a therapeutic agent comprising: an implantable composition containing: a plurality of optically heatable particles capable of converting incident radiation into heat energy when said particles are irradiated with electromagnetic radiation; at least one therapeutic agent, and a medium comprising a thermally responsive material in contact with said particles, said material substantially retaining said agent at a first temperature and substantially releasing said agent at a second temperature that is higher than said first temperature; and optionally, a biosensor system.
Claim 19
Independent Claim
87 words
A system for modulated in vivo delivery of a therapeutic agent comprising: an implantable composition containing: a plurality of optically heatable particles capable of converting incident radiation into heat energy when said particles are irradiated with electromagnetic radiation; at least one therapeutic agent, and a medium comprising a thermally responsive material in contact with said particles, said material substantially retaining said agent at a first temperature and substantially releasing said agent at a second temperature that is higher than said first temperature; and optionally, a biosensor system.
References Cited (Backward Citations)
US5213788A
Cited
US5427767A
Cited
US6068857A
Cited
US6344272B1
Cited
US5993374A
Cited
US5945293A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-08-05 | 2006-02-04 | 2006-08-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-08-05 | 2010-02-04 | 2010-08-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-08-05 | 2014-02-04 | 2014-08-06 | $7700.00 | Window Closed / Lapsed |