US5650156A
Expired / Lapsed
US
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Methods for in vivo delivery of nutriceuticals and compositions useful therefor
Assignee: Abraxis Bioscience LLC
•
Filing: 1995-06-07
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Granted: 1997-07-22
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Expires: 2015-06-07
Abstract
Abstract In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
Inventors
- 👤 Mark W. Grinstaff
- 👤 Patrick Soon-Shiong
- 👤 Michael Wong
- 👤 Paul A. Sandford
- 👤 Kenneth S. Suslick
- 👤 Neil P. Desai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 07:47
CPC Classifications
A; A23; A23L; A23L33/00; A23L33/40; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6921; A61K47/6925; A61K47/6927; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/12; A61K49/126; A61K49/18; A61K49/1818; A61K49/1821; A61K49/1824; A61K49/1827; A61K49/1851; A61K49/1863; A61K49/22; A61K49/222; A61K49/223; A61K49/226; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5052; A61K9/51; A61K9/5107; A61K9/513; A61K9/5138; A61K9/5146; A61K9/5161; A61K9/5169; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
77 words
A method for the preparation of articles for in vivo delivery of nutriceuticals, said method comprising subjecting aqueous medium containing biocompatible material capable of being crosslinked by disulfide bonds and a nutriceutical to high intensity ultrasound conditions for a time sufficient to promote crosslinking of said biocompatible material by disulfide bonds; wherein said nutriceutical is substantially contained within a polymeric shell, and wherein the largest cross-sectional dimension of said shell is no greater than about 10 microns.
Claim 2
Independent Claim
77 words
A method for the preparation of articles for in vivo delivery of nutriceuticals, said method comprising subjecting aqueous medium containing biocompatible material capable of being crosslinked by disulfide bonds and a nutriceutical to high intensity ultrasound conditions for a time sufficient to promote crosslinking of said biocompatible material by disulfide bonds; wherein said nutriceutical is substantially contained within a polymeric shell, and wherein the largest cross-sectional dimension of said shell is no greater than about 10 microns.
Claim 3
Dependent Claim
37 words
The method according to claim 1, wherein said biocompatible material is a naturally occurring polymer, a synthetic polymer, or a combination thereof, wherein said polymer, prior to crosslinking, has covalently attached thereto sulfhydryl groups or disulfide linkages.
Claim 4
Dependent Claim
28 words
The method according to claim 1, wherein said nutriceutical is selected from amino acids, sugars, proteins, carbohydrates, fat-soluble vitamins, fat, or combinations of any two or more thereof.
Claim 5
Dependent Claim
21 words
The method according to claim 1, wherein said nutriceutical within said shell is dissolved or suspended in a biocompatible dispersing agent.
Claim 6
Dependent Claim
49 words
A method for the delivery of a nutriceutical to a subject in need thereof, said method comprising administering to said subject the articles prepared by the method of claim 1 by oral, intravenous, subcutaneous, intraperitoneal, intrathecal, intramuscular, intracranial, inhalational, topical, transdermal, suppository (rectal), or pessary (vaginal) routes of administration.
Claim 7
Independent Claim
68 words
A method for the preparation of articles for in vivo delivery of nutriceuticals, said method comprising subjecting aqueous medium containing a nutriceutical capable of being crosslinked by disulfide bonds to high intensity ultrasound conditions for a time sufficient to promote crosslinking of said biocompatible material by disulfide bonds to form a polymeric shell; wherein the largest cross-sectional dimension of said shell is no greater than about 10 microns.
Claim 8
Independent Claim
68 words
A method for the preparation of articles for in vivo delivery of nutriceuticals, said method comprising subjecting aqueous medium containing a nutriceutical capable of being crosslinked by disulfide bonds to high intensity ultrasound conditions for a time sufficient to promote crosslinking of said biocompatible material by disulfide bonds to form a polymeric shell; wherein the largest cross-sectional dimension of said shell is no greater than about 10 microns.
Claim 9
Dependent Claim
36 words
The method according to claim 6, wherein said nutriceutical is a naturally occurring polymer, a synthetic polymer, or a combination thereof, wherein said polymer, prior to crosslinking, has covalently attached thereto sulfhydryl groups or disulfide linkages.
Claim 10
Dependent Claim
28 words
The method according to claim 6, wherein said nutriceutical is selected from amino acids, sugars, proteins, carbohydrates, fat-soluble vitamins, fat, or combinations of any two or more thereof.
Claim 11
Dependent Claim
49 words
A method for the delivery of a nutriceutical to a subject in need thereof, said method comprising administering to said subject the articles prepared by the method of claim 1 by oral, intravenous, subcutaneous, intraperitoneal, intrathecal, intramuscular, intracranial, inhalational, topical, transdermal, suppository (rectal), or pessary (vaginal) routes of administration.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2000-07-21 | 2001-01-20 | 2001-07-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-07-21 | 2005-01-20 | 2005-07-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-07-21 | 2009-01-20 | 2009-07-22 | $7700.00 | Window Closed / Lapsed |