EP0213303B1
Expired / Lapsed
EP
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A method for producing small, spherical polymer particles
Assignee: Jagotec AG
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Filing: 1986-06-23
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Granted: 1991-09-04
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Expires: 2006-06-23
Abstract
Abstract The invention relates to a method of producing small spherical polymer particles from systems containing two liquid phases, the one phase of which contains one or more dissolved substances and is dispersed in the form of small droplets in the other phase to form an emulsion, whereafter the droplets are converted to a solid form. According to the invention the liquid phases used are two mutually immiscible aqueous phases.
Inventors
- 👤 Bo Magnus Ekman
- 👤 Ake Rikard Lindahl
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 15:14
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1682; A61K9/1694; C; C08; C08J; C08J3/00; C08J3/12; C08J3/14; C08J3/16
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
61 words
A method of producing small spherical polymer particles from systems containing two liquid phases, the one phase of which contains one or more dissolved substances and is dispersed in the form of small droplets in the other phase to form an emulsion, whereafter the droplets are caused to solidify, characterized by using two mutually immiscible aqueous phases as the liquid phases.
Claim 2
Dependent Claim
39 words
A method according to Claim 1, characterized by using as a dissolved substance in said one phase a substance which has a moderate solubility in water; and by causing the droplets to solidify by removing water from the same.
Claim 3
Dependent Claim
39 words
A method according to Claim 1, characterized by using as a dissolved substance in said one phase methylcellulose or one or more proteins, and by effecting the conversion of the droplets to a solid form by heating the system.
Claim 4
Dependent Claim
40 words
A method according to Claim 1, characterized by using as a dissolved substance a polymer whose solubility in water is greatly dependent on temperature; and by effecting the conversion of the droplets to a solid form by cooling the system.
Claim 5
Dependent Claim
47 words
A method according to Claim 1, characterized by using as a dissolved substance a polymer exhibiting hydroxyl groups and/or amino groups or groups containing the structure CH₂ = CH-; and by effecting the conversion of the droplets to a solid form by means of a cross-linking reaction.
Claim 6
Dependent Claim
42 words
A method according to Claim 1, characterized by using as a dissolved substance a polymer whose solubility is greatly dependent on pH; and by effecting the conversion of the droplets to a solid form by altering the pH-value of the dispersed phase.
Claim 7
Dependent Claim
47 words
A method according to Claim 1, characterized by using as a dissolved substance a polymer which forms a sparingly soluble salt with a counter-ion, preferably a non-toxic counter-ion; and by effecting the conversion of the droplets to a solid form, by adding such counter-ion to the system.
Claim 8
Dependent Claim
68 words
A method according to Claim 1, characterized by using as a dissolved substance at least one substance which constitutes a component in a system of at least two substances which react with one another to form a conjugate or complex which is insoluble in an aqueous medium; and by effecting the conversion of the droplets to a solid form with the aid of remaining components in said system.
Claim 9
Dependent Claim
33 words
A method according to Claim 1, characterized in that the conversion of the droplets to a solid form is effected by splitting-off hydrophilic substituents from and/or introducing hydrophobic substituents into the dissolved substance.
Claim 10
Independent Claim
78 words
A method according to any of the preceding claims, characterized in that one or more substances, preferably macromolecular substances, which are inert during conversion of the droplets to solid form, are included as dissolved substances in the dispersed phase and enclosed or entrapped in the particles during the formation thereof, or that whole cells, cell organelles or solid particles or small oil droplets are dispersed in the dispersed phase and encapsulated in the particles as they are formed.
References Cited (Backward Citations)
No citation records indexed.
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