US7128073B1 — Method and device for left atrial appendage occlu…

Claim 1

Independent Claim 235 words

A containment device for positioning at a left atrial appendage, comprising: a proximal end, a distal end, an intermediate portion between the proximal and distal ends, and a longitudinal axis extending therethrough; at least three supports extending between the proximal end and the distal end; each support comprising an elongate, flexible element which is movable from a first orientation in which the element extends substantially parallel to the axis at no more than a first distance from the axis, to a second orientation in which at least a portion of the element is inclined toward the intermediate portion with respect to the axis and is separated by at least a second distance from the axis which is greater than the first distance, wherein the intermediate portion in the second orientation is sized and configured to engage a surface at the left atrial appendage and the supports in their second orientation increase radially in dimension from the proximal end to an apex portion and then decrease radially in dimension from the apex portion to the distal end; and an endothelialization membrane carried by the device, for promoting endothelialization across the left atrial appendage, wherein the endothelialization membrane at least in part comprises a first membrane on a first side of the supports, a second membrane on a second side of the supports, and a bonding layer for bonding the first membrane and the second membrane together.

Claim 2

Dependent Claim 235 words

A containment device for positioning at a left atrial appendage, comprising: a proximal end, a distal end, an intermediate portion between the proximal and distal ends, and a longitudinal axis extending therethrough; at least three supports extending between the proximal end and the distal end; each support comprising an elongate, flexible element which is movable from a first orientation in which the element extends substantially parallel to the axis at no more than a first distance from the axis, to a second orientation in which at least a portion of the element is inclined toward the intermediate portion with respect to the axis and is separated by at least a second distance from the axis which is greater than the first distance, wherein the intermediate portion in the second orientation is sized and configured to engage a surface at the left atrial appendage and the supports in their second orientation increase radially in dimension from the proximal end to an apex portion and then decrease radially in dimension from the apex portion to the distal end; and an endothelialization membrane carried by the device, for promoting endothelialization across the left atrial appendage, wherein the endothelialization membrane at least in part comprises a first membrane on a first side of the supports, a second membrane on a second side of the supports, and a bonding layer for bonding the first membrane and the second membrane together.

Claim 3

Dependent Claim 13 words

A containment device as in claim 1 , comprising at least five supports.

Claim 4

Dependent Claim 17 words

A containment device as in claim 1 , comprising from about five supports to about twenty supports.

Claim 5

Dependent Claim 21 words

A containment device as in claim 3 , further comprising at least one barb on each of at least two supports.

Claim 6

Dependent Claim 25 words

A containment device as in claim 1 , further comprising a proximal hub at the proximal end and a distal hub at the distal end.

Claim 7

Dependent Claim 24 words

A containment device as in claim 5 , wherein the supports and the proximal hub and the distal hub are formed from a tube.

Claim 8

Dependent Claim 24 words

A containment device as in claim 5 , wherein the supports and the proximal hub and the distal hub are formed from a sheet.

Claim 9

Dependent Claim 17 words

A containment device as in claim 1 , further comprising at least one barb on each support.

Claim 10

Dependent Claim 16 words

A containment device as in claim 1 , wherein the supports comprise a nickel titanium alloy.

Claim 11

Dependent Claim 14 words

A containment device as in claim 1 , wherein the supports comprise stainless steel.

Claim 12

Dependent Claim 16 words

A containment device as in claim 1 , wherein the first and second membranes comprise ePTFE.

Claim 13

Dependent Claim 16 words

A containment device as in claim 1 , wherein the first and second membranes comprise Dacron.

Claim 14

Dependent Claim 16 words

A containment device as in claim 1 , where the first and second membranes comprise nylon.

Claim 15

Dependent Claim 23 words

A containment device as in claim 1 , wherein the endothelialization membrane has a pore size of no greater than about 0.04 inches.

Claim 16

Dependent Claim 17 words

A containment device as in claim 1 , wherein the containment device comprises a self expandable structure.

Claim 17

Dependent Claim 16 words

A containment device as in claim 15 , wherein the self expandable structure comprises wire mesh.

Claim 18

Dependent Claim 16 words

A containment device as in claim 15 , wherein the self expandable structure comprises braided wire.

Claim 19

Dependent Claim 16 words

A containment device as in claim 15 , wherein the self expandable structure comprises wire coil.

Claim 20

Dependent Claim 17 words

A containment device as in claim 15 , wherein the self expandable structure comprises shape memory material.

Claim 21

Dependent Claim 16 words

A containment device as in claim 15 , wherein the self expandable structure comprises pseudoelastic alloy.

Claim 22

Dependent Claim 17 words

A containment device as in claim 15 , wherein the self expandable structure comprises nickel titanium alloy.

Claim 23

Dependent Claim 16 words

A containment device as in claim 15 , wherein the self expandable structure comprises stainless steel.

Claim 24

Dependent Claim 16 words

A containment device as in claim 15 , wherein the self expandable structure comprises composite material.

Claim 25

Dependent Claim 18 words

A containment device as in claim 1 , wherein the containment device comprises a self expandable wire structure.

Claim 26

Dependent Claim 108 words

A containment device for implantation at an opening in the body, comprising: a support member movable from a reduced cross-section to an enlarged cross-section, the support member in the enlarged cross-section extending from a proximal end and inclining radially outward to an apex portion, and then inclining radially inward to a distal end; and a porous endothelialization membrane carried by the support member, wherein the endothelialization membrane at least in part comprises a first membrane on a first side of the support member, a second membrane on a second side of the support member, and a bonding layer for bonding the first membrane and the second membrane together.

Claim 27

Dependent Claim 108 words

A containment device for implantation at an opening in the body, comprising: a support member movable from a reduced cross-section to an enlarged cross-section, the support member in the enlarged cross-section extending from a proximal end and inclining radially outward to an apex portion, and then inclining radially inward to a distal end; and a porous endothelialization membrane carried by the support member, wherein the endothelialization membrane at least in part comprises a first membrane on a first side of the support member, a second membrane on a second side of the support member, and a bonding layer for bonding the first membrane and the second membrane together.

Claim 28

Dependent Claim 25 words

A containment device as in claim 25 , further comprising at least one hub on the support member and a plurality of spokes extending therefrom.

Claim 29

Dependent Claim 17 words

A containment device as in claim 26 , wherein the support member comprises at least eight spokes.

Claim 30

Dependent Claim 30 words

A containment device as in claim 26 , wherein at least one spoke has a first end and a second end, and the first end is attached to the hub.

Claim 31

Dependent Claim 37 words

A containment device as in claim 26 , wherein each spoke comprises a proximal section, a distal section, and a bend in between the proximal and distal sections when the support member is in the enlarged cross-section.

Claim 32

Dependent Claim 16 words

A containment device as in claim 26 , wherein the spokes are cut from a tube.

Claim 33

Dependent Claim 16 words

A containment device as in claim 26 , comprising at least one barb on each spoke.

Claim 34

Dependent Claim 16 words

A containment device as in claim 26 , wherein the spokes comprise a nickel titanium alloy.

Claim 35

Dependent Claim 14 words

A containment device as in claim 26 , wherein the spokes comprise stainless steel.

Claim 36

Dependent Claim 14 words

A containment device as in claim 25 , wherein the support member comprises wire.

Claim 37

Dependent Claim 19 words

A containment device as in claim 25 , further comprising at least one tissue attachment element on the support.

Claim 38

Dependent Claim 18 words

A containment device as in claim 35 , wherein the tissue attachment element comprises a tissue piercing element.

Claim 39

Dependent Claim 20 words

A containment device as in claim 25 , further comprising at least one tissue attachment element on the support member.

Claim 40

Dependent Claim 16 words

A containment device as in claim 25 , wherein the first and second membranes comprise ePTFE.

Claim 41

Dependent Claim 16 words

A containment device as in claim 25 , wherein the first and second membranes comprises Dacron.

Claim 42

Dependent Claim 16 words

A containment device as in claim 25 , where the first and second membranes comprises nylon.

Claim 43

Dependent Claim 23 words

A containment device as in claim 25 , wherein the endothelialization membrane has a pore size of no greater than about 0.04 inches.

Claim 44

Dependent Claim 17 words

A containment device as in claim 25 , wherein the containment device comprises a self expandable structure.

Claim 45

Dependent Claim 18 words

A containment device as in claim 42 , wherein the containment device comprises a self expandable wire structure.

Claim 46

Dependent Claim 16 words

A containment device as in claim 42 , wherein the self expandable structure comprises wire mesh.

Claim 47

Dependent Claim 16 words

A containment device as in claim 42 , wherein the self expandable structure comprises braided wire.

Claim 48

Dependent Claim 16 words

A containment device as in claim 42 , wherein the self expandable structure comprises wire coil.

Claim 49

Dependent Claim 17 words

A containment device as in claim 42 , wherein the self expandable structure comprises shape memory material.

Claim 50

Dependent Claim 16 words

A containment device as in claim 42 , wherein the self expandable structure comprises pseudoelastic alloy.

Claim 51

Dependent Claim 17 words

A containment device as in claim 42 , wherein the self expandable structure comprises nickel titanium alloy.

Claim 52

Dependent Claim 16 words

A containment device as in claim 42 , wherein the self expandable structure comprises stainless steel.

Claim 53

Dependent Claim 16 words

A containment device as in claim 42 , wherein the self expandable structure comprises composite material.

Claim 54

Dependent Claim 32 words

A containment device as in claim 42 , wherein the self expandable structure has at least one proximally concave surface and at least one distally concave surface when in an expanded configuration.

Claim 55

Dependent Claim 15 words

A containment device as in claim 25 , wherein the bonding layer comprises a mesh.

Claim 56

Dependent Claim 13 words

A containment device as in claim 53 , wherein the mesh comprises polyethylene.

Claim 57

Dependent Claim 26 words

A containment device as in claim 54 , wherein the mesh has an open surface area within the range of from about 10% to about 90%.

Claim 58

Dependent Claim 26 words

A containment device as in claim 54 , wherein the mesh has an open surface area within the range of from about 30% to about 60%.

Claim 59

Dependent Claim 30 words

A containment device as in claim 25 , wherein the device in its enlarged cross-section has a maximum transverse dimension adapted to engage a surface at a left atrial appendage.

Claim 60

Dependent Claim 18 words

A containment device as in claim 25 , wherein the apex portion is elongated in an axial direction.

Claim 61

Independent Claim 253 words

A device for implantation within a left atrial appendage of a patient, the device comprising: an expandable frame having a proximal end, a distal end, and a longitudinal axis extending therethrough, the frame comprising a plurality of supports; each support comprising an elongate, flexible element, at least some of the supports being movable from a first orientation in which the element extends substantially parallel to the axis at no more than a first distance from the axis, to a second orientation in which at least a portion of the element is inclined with respect to the axis and is separated by at least a second distance from the axis which is greater than the first distance, wherein the supports in their second orientation increase radially in dimension from the proximal end to an apex portion and then decrease radially in dimension from the apex portion to the distal end; and an endothelialization membrane attached to at least a proximal face of the device having a pore size sufficient to permit endothelialization, the proximal face of the device comprising at least in part the inclined portion of a plurality of the flexible elements and being sized and configured to block an opening to the left atrial appendage; wherein the endothelialization membrane has a porosity in the range of about 5 to about 60 microns; wherein the endothelialization membrane comprises a first membrane and a second membrane, wherein the first membrane and second membrane are attached to each other on opposite sides of the supports.

Claim 62

Independent Claim 253 words

A device for implantation within a left atrial appendage of a patient, the device comprising: an expandable frame having a proximal end, a distal end, and a longitudinal axis extending therethrough, the frame comprising a plurality of supports; each support comprising an elongate, flexible element, at least some of the supports being movable from a first orientation in which the element extends substantially parallel to the axis at no more than a first distance from the axis, to a second orientation in which at least a portion of the element is inclined with respect to the axis and is separated by at least a second distance from the axis which is greater than the first distance, wherein the supports in their second orientation increase radially in dimension from the proximal end to an apex portion and then decrease radially in dimension from the apex portion to the distal end; and an endothelialization membrane attached to at least a proximal face of the device having a pore size sufficient to permit endothelialization, the proximal face of the device comprising at least in part the inclined portion of a plurality of the flexible elements and being sized and configured to block an opening to the left atrial appendage; wherein the endothelialization membrane has a porosity in the range of about 5 to about 60 microns; wherein the endothelialization membrane comprises a first membrane and a second membrane, wherein the first membrane and second membrane are attached to each other on opposite sides of the supports.

Claim 63

Dependent Claim 23 words

The device of claim 59 , further comprising a proximal hub at the proximal end and a distal hub at the distal end.

Claim 64

Dependent Claim 14 words

The device of claim 59 , wherein the supports comprise a nickel titanium alloy.

Claim 65

Dependent Claim 11 words

The device of claim 59 , wherein the membrane comprises ePTFE.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2009-10-30	2010-05-01	2010-10-31	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2013-10-30	2014-05-01	2014-10-31	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2017-10-30	2018-05-01	2018-10-31	$7700.00	Window Closed / Lapsed

Method and device for left atrial appendage occlusion

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