US6939377B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coated vascular grafts and methods of use
Assignee: TC1 LLC
•
Filing: 2001-08-20
•
Granted: 2005-09-06
•
Expires: 2021-08-20
Abstract
Abstract A vascular graft, such as an AAA stent graft, includes a core zone of PET fabric with a non-porous coating comprising a polyurethane, such as Thoralon®, disposed on at least one surface. The coating provides a barrier to prevent short and long term leakage of fluids through the pores of the PET fabric core zone. A method for sealing the pores of a porous PET graft includes the step of coating at least one surface of said graft with at least one polyurethane, or mixtures and combinations thereof. Preferably, the coating is Thoralon®. A method for making a vascular prosthesis includes the steps of providing a core zone of PET fabric, and coating at least one surface of the core zone with at least one polyurethane, or mixtures and combinations thereof, such as Thoralon®. Finally, a method of repairing or treating a defective vessel includes the step of reinforcing or replacing the defective vessel with a graft according to the invention.
Inventors
- 👤 Ramesh B. Jayaraman
- 👤 Christofer T. Christoforou
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 02:48
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61L27/28; A61L27/34
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
96 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein the coating comprises a polyurethane urea, wherein said first coating has a thickness of about 12 μm.
Claim 2
Dependent Claim
96 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein the coating comprises a polyurethane urea, wherein said first coating has a thickness of about 12 μm.
Claim 3
Dependent Claim
105 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein the coating comprises a polyetherurethane urea blended with a siloxane containing a surface modifying additive, wherein said first coating has a thickness of about 12 μm.
Claim 4
Dependent Claim
105 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein the coating comprises a polyetherurethane urea blended with a siloxane containing a surface modifying additive, wherein said first coating has a thickness of about 12 μm.
Claim 5
Dependent Claim
103 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein said at least one polyurethane comprises a soft segment and a hard segment, wherein said first coating has a thickness of about 12 μm.
Claim 6
Dependent Claim
103 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein said at least one polyurethane comprises a soft segment and a hard segment, wherein said first coating has a thickness of about 12 μm.
Claim 7
Dependent Claim
17 words
The graft of claim 3 wherein the soft segment has a molecular weight of about 2,000 g/mole.
Claim 8
Dependent Claim
44 words
The graft of claim 3 wherein the soft segment comprises one or more compounds selected from the group consisting of polyethylene oxide, polypropylene oxide, polytetramethylene oxide, polycarbonate, polyolefin, polysiloxane, polyether soft segments made from higher homologous series of diols, and mixtures and combinations thereof.
Claim 9
Dependent Claim
113 words
The graft of claim 3 wherein the hard segment comprises one or more compounds selected from the group consisting of 4,4′-diphenylmethane diisocyanate, tetramethylene diisocyanate, hexamethylene diisocyanate, trimethyhexamethylene diisocyanate, tetramethylxylylene diisocyanate, 4,4′-decyclohexylmethane diisocyanate, dimer acid diisocyanate, isophorone diisocyanate, metaxylene diisocyanate, diethylbenzene diisocyanate, decamethylene 1,10 diisocyanate, cyclohexylene 1,2-diisocyanate, 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, xylene diisocyanate, m-phenylene diisocyanate, hexahydrotolylene diisocyanate (and isomers), naphthylene-1,5-diisocyanate, 1-methoxyphenyl2,4-diisocyanate, 4,4′-biphenylene diisocyanate, 3,3-dimethoxy-4,4′-biphenyl diisocyanate, ethylene diamine, propane diamines, butanediamines, hexanediamines, pentane diamines, heptane diamines, octane diamines, m-xylylene diamine, 1,4-cyclohexane diamine, 2-methypentamethylene diamine, 4,4′-methylene dianiline, alkanol amines and diamines, ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, neopentyl alcohol, 1,6-hexanediol, 1,8-octanediol, propylene glycols, 2,3-butylene glycol, dipropylene glycol, dibutylene glycol, glycerol, and mixtures and combinations thereof.
Claim 10
Dependent Claim
33 words
The graft of claim 3 wherein said coating comprises a polyether urethane urea, and wherein said soft segment comprises polytetramethylene oxide (PTMO) and said hard segment comprises 4,4′-diphenylmethane diisocyanate (MDI) and ethylene diamine.
Claim 11
Dependent Claim
103 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein the coating comprises a polyurethane urea, wherein said first coating has a thickness in a range of about 4 μm to about 5 μm.
Claim 12
Dependent Claim
103 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein the coating comprises a polyurethane urea, wherein said first coating has a thickness in a range of about 4 μm to about 5 μm.
Claim 13
Dependent Claim
112 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein the coating comprises a polvetherurethane urea blended with a siloxane containing a surface modifying additive, wherein said first coating has a thickness in a range of about 4 μm to about 5 μm.
Claim 14
Dependent Claim
112 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein the coating comprises a polvetherurethane urea blended with a siloxane containing a surface modifying additive, wherein said first coating has a thickness in a range of about 4 μm to about 5 μm.
Claim 15
Dependent Claim
110 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein said at least one polyurethane comprises a soft segment and a hard segment, wherein said first coating has a thickness in a range of about 4 μm to about 5 μm.
Claim 16
Dependent Claim
110 words
A vascular graft comprising: a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane; wherein said at least one polyurethane comprises a soft segment and a hard segment, wherein said first coating has a thickness in a range of about 4 μm to about 5 μm.
Claim 17
Dependent Claim
17 words
The graft of claim 10 wherein the soft segment has a molecular weight of about 2000 g/mole.
Claim 18
Dependent Claim
44 words
The graft of claim 10 wherein the soft segment comprises one or more compounds selected from the group consisting of polyethylene oxide, polypropylene oxide, polytetramethylene oxide, polycarbonate, polyolefin, polysiloxane, polyether soft segments made from higher homologous series of diols, and mixtures and combinations thereof.
Claim 19
Dependent Claim
113 words
The graft of claim 10 wherein the hard segment comprises one or more compounds selected from the group consisting of 4,4′-diphenylmethane diisocyanate, tetramethylene diisocyanate, hexamethylene diisocyanate, trimethyhexamethylene diisocyanate, tetramethylxylylene diisocyanate, 4,4′-decyclohexylmethane diisocyanate, dimer acid diisocyanate, isophorone diisocyanate, metaxylene diisocyanate, diethylbenzene diisocyanate, decamethylene 1,10 diisocyanate, cyclohexylene 1,2-diisocyanate, 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, xylene diisocyanate, m-phenylene diisocyanate, hexahydrotolylene diisocyanate (and isomers), naphthylene-1,5-diisocyanate, 1-methoxyphenyl2,4-diisocyanate, 4,4′-biphenylene diisocyanate, 3,3-dimethoxy-4,4′-biphenyl diisocyanate, ethylene diamine, propane diamines, butanediamines, hexanediamines, pentane diamines, heptane diamines, octane diamines, m-xylylene diamine, 1,4-cyclohexane diamine, 2-methypentamethylene diamine, 4,4′-methylene dianiline, alkanol amines and diamines, ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, neopentyl alcohol, 1,6-hexanediol, 1,8-octanediol, propylene glycols, 2,3-butylene glycol, dipropylene glycol, dibutylene glycol, glycerol, and mixtures and combinations thereof.
References Cited (Backward Citations)
US2900644A
Cited
US3862452A
Cited
US3562820A
Cited
US3562352A
Cited
US3700380A
Cited
US3789828A
Cited
US4355426A
Cited
US4459252A
Cited
US4173689A
Cited
US4131604A
Cited
US4306318A
Cited
US4304010A
Cited
US4828561A
Cited
US4334327A
Cited
GB2140438A
Cited
US4675361A
Cited
US4861830A
Cited
US4604762A
Cited
US4731073A
Cited
US4623347A
Cited
US4695281A
Cited
US4647416A
Cited
US5108424A
Cited
US4743258A
Cited
US4687482A
Cited
US4678468A
Cited
US4996054A
Cited
US4784659A
Cited
US4957508A
Cited
US4816339A
Cited
US5017664A
Cited
US5486593A
Cited
US5412068A
Cited
US5274074A
Cited
US4892544A
Cited
US5575815A
Cited
US5019090A
Cited
US5100422A
Cited
US5104400A
Cited
US5152782A
Cited
EP0448840A3
Cited
EP0448840A2
Cited
US5298276A
Cited
US5116360A
Cited
US5330782A
Cited
US5126181A
Cited
US5607474A
Cited
US5861033A
Cited
US5589563A
Cited
US5779729A
Cited
US5735897A
Cited
US6309413B1
Cited
US5855598A
Cited
US5891558A
Cited
WO1996030060A1
Cited
US5741333A
Cited
US6096070A
Cited
US5782907A
Cited
US5713907A
Cited
US6083257A
Cited
US6042605A
Cited
US20010049550A1
Cited
US6241774B1
Cited
WO1998027895A1
Cited
US6015431A
Cited
US6225435B1
Cited
US6197051B1
Cited
US5980564A
Cited
US5863627A
Cited
US5984965A
Cited
US6254642B1
Cited
US5948875A
Cited
US6013099A
Cited
US6156064A
Cited
WO2000010487A1
Cited
US6264700B1
Cited
US6302917B1
Cited
WO2000027897A2
Cited
US6177523B1
Cited
US20010002444A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2008-09-05 | 2009-03-07 | 2009-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2012-09-05 | 2013-03-07 | 2013-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2016-09-05 | 2017-03-07 | 2017-09-06 | $7700.00 | Window Closed / Lapsed |