Patent US6866651B2 successfully refreshed from Google Patents.
US6866651B2
Expired / Lapsed
US
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Methods and devices for the in situ dissolution of renal calculi
Assignee: Cordis US Corp
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Filing: 2002-03-20
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Granted: 2005-03-15
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Expires: 2022-03-20
Abstract
Abstract Methods and devices for at least reducing the mass of, if not dissolving, renal calculi in situ are provided. In the subject methods, a renal calculus is contacted, e.g. flushed, with an acidic dissolution solution in situ, where the acidic dissolution solution is a solution of a strong, inorganic acid, e.g. hydrochloric acid. In many embodiments, the renal calculus is first enclosed in an isolated local environment of a device prior contact with the dissolution solution. Also provided are novel devices and kits for practicing the subject invention.
Inventors
- 👤 Brent R. Constantz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:23
CPC Classifications
A; A61; A61K; A61K33/00; A61B; A61B17/00; A61B17/22; A61B2017/22082; A61B2017/22084
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
117 words
A method for at least reducing the mass of a renal calculus in situ, said method comprising: contacting said renal calculus with a dissolution solution of a strong, inorganic acid having a pH of less than about 3 for a period of time sufficient to at least reduce the mass of said renal calculus using a device comprising:a means for enclosing said renal calculus in a substantially isolated local environment, wherein said means comprises an element that expands along a circumference about a central longitudinal axis to produce said isolated local environment which is characterized by having a circular cross-sectional shape in any plane normal to said longitudinal axis; to reduce the mass of said renal calculus.
Claim 2
Independent Claim
117 words
A method for at least reducing the mass of a renal calculus in situ, said method comprising: contacting said renal calculus with a dissolution solution of a strong, inorganic acid having a pH of less than about 3 for a period of time sufficient to at least reduce the mass of said renal calculus using a device comprising:a means for enclosing said renal calculus in a substantially isolated local environment, wherein said means comprises an element that expands along a circumference about a central longitudinal axis to produce said isolated local environment which is characterized by having a circular cross-sectional shape in any plane normal to said longitudinal axis; to reduce the mass of said renal calculus.
Claim 3
Independent Claim
126 words
A method for at least reducing the mass of a renal calculus, said method comprising: enclosing said renal calculus in a device in a manner such that said renal calculus is positioned within an isolated local environment in situ, said device comprising: a means for enclosing said renal calculus in a substantially isolated local environment, wherein said means comprises an element that expands along a circumference about a central longitudinal axis to produce said isolated local environment which is characterized by having a circular cross-sectional shape in any plane normal to said longitudinal axis; and flushing said isolated local environment with an acidic dissolution solution of a strong inorganic acid having a pH of less than about 3; to reduce the mass of said renal calculus.
Claim 4
Independent Claim
126 words
A method for at least reducing the mass of a renal calculus, said method comprising: enclosing said renal calculus in a device in a manner such that said renal calculus is positioned within an isolated local environment in situ, said device comprising: a means for enclosing said renal calculus in a substantially isolated local environment, wherein said means comprises an element that expands along a circumference about a central longitudinal axis to produce said isolated local environment which is characterized by having a circular cross-sectional shape in any plane normal to said longitudinal axis; and flushing said isolated local environment with an acidic dissolution solution of a strong inorganic acid having a pH of less than about 3; to reduce the mass of said renal calculus.
Claim 5
Dependent Claim
25 words
The method according to claim 2 , wherein said flushing comprises introducing and removing fluid from said isolated local environment at substantially the same rate.
Claim 6
Dependent Claim
13 words
The method according to claim 2 , wherein said renal calculus comprises calcium.
Claim 7
Dependent Claim
17 words
The method according to claim 2 , wherein said acidic dissolution solution is a hydrochloric acid solution.
Claim 8
Independent Claim
145 words
A method for at least reducing the mass of a calcium comprising renal calculus, said method comprising: enclosing said calcium comprising renal calculus in a device in situ in a manner such that said calcium comprising renal calculus is positioned within an isolated local environment in situ, said device comprising: a means for enclosing said renal calculus in a substantially isolated local environment, wherein said means comprises an element that expands along a circumference about a central longitudinal axis to produce said isolated local environment which is characterized by having a circular cross-sectional shape in any plane normal to said longitudinal axis; and flushing said isolated local environment with hydrochloric acid dissolution solution having a pH of less than about 3 by introducing and removing said solution from said isolated local environment at substantially the same rate; to reduce the mass of said renal calculus.
Claim 9
Independent Claim
145 words
A method for at least reducing the mass of a calcium comprising renal calculus, said method comprising: enclosing said calcium comprising renal calculus in a device in situ in a manner such that said calcium comprising renal calculus is positioned within an isolated local environment in situ, said device comprising: a means for enclosing said renal calculus in a substantially isolated local environment, wherein said means comprises an element that expands along a circumference about a central longitudinal axis to produce said isolated local environment which is characterized by having a circular cross-sectional shape in any plane normal to said longitudinal axis; and flushing said isolated local environment with hydrochloric acid dissolution solution having a pH of less than about 3 by introducing and removing said solution from said isolated local environment at substantially the same rate; to reduce the mass of said renal calculus.
Claim 10
Dependent Claim
16 words
The method according to claim 6 , wherein said calcium renal calculus comprises a calcium phosphate.
Claim 11
Dependent Claim
16 words
The method according to claim 6 , wherein said calcium renal calculus comprises a calcium oxalate.
Claim 12
Independent Claim
84 words
A device for use in at least reducing the mass of a renal calculus in situ, said device comprising: a means for enclosing said renal calculus in a substantially isolated local environment, wherein said means comprises an element that expands along a circumference about a central longitudinal axis to produce said isolated local environment which is characterized by having a circular cross-sectional shape in any plane normal to said longitudinal axis; and a strong, inorganic acid having a pH of less than about 3.
Claim 13
Independent Claim
84 words
A device for use in at least reducing the mass of a renal calculus in situ, said device comprising: a means for enclosing said renal calculus in a substantially isolated local environment, wherein said means comprises an element that expands along a circumference about a central longitudinal axis to produce said isolated local environment which is characterized by having a circular cross-sectional shape in any plane normal to said longitudinal axis; and a strong, inorganic acid having a pH of less than about 3.
Claim 14
Dependent Claim
25 words
The device according to claim 9 , wherein said device further comprises at least one fluid conduit in fluid communication with said isolated local environment.
Claim 15
Dependent Claim
25 words
The device according to claim 9 , wherein said device further comprises at least two fluid conduits in fluid communication with said isolated local environment.
Claim 16
Dependent Claim
77 words
A kit for use in reducing the mass of a renal calculus, said kit comprising: an dissolution solution of a strong, inorganic acid having a pH of less than about 3; and a device comprising a means for enclosing said renal calculus in a substantially isolated local environment, wherein said means comprises an axis to produce said isolated local environment which is characterized by having a circular cross-sectional shape in any plane normal to said longitudinal axis.
Claim 17
Dependent Claim
77 words
A kit for use in reducing the mass of a renal calculus, said kit comprising: an dissolution solution of a strong, inorganic acid having a pH of less than about 3; and a device comprising a means for enclosing said renal calculus in a substantially isolated local environment, wherein said means comprises an axis to produce said isolated local environment which is characterized by having a circular cross-sectional shape in any plane normal to said longitudinal axis.
Claim 18
Dependent Claim
14 words
The kit according to claim 12 , wherein said dissolution solution comprises hydrochloric acid.
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