US4156721A
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Method of production of active substance of an antinephrolithiatic, the antinephrolithiatic, and its application for therapy of the nephrolithiasis
Assignee: Instytut Chemii Nieorganicznej
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Filing: 1978-02-09
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Granted: 1979-05-29
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Expires: 1998-02-09
Abstract
Abstract A method of production of the active substance of an antilithiatic medicament, wherein ground seeds of the genus Dolichos are extracted with polar solvents, then the extract is contingently submitted to an acid hydrolysis, whereafter the acid hydrolyzate is contingently extracted with solvents immiscible with water, and then it is neutralized and contingently, is described. The antilithiatic medicament contains the active substance produced according to the method of the invention. It is employed for therapy in nephrolithiasis.
Inventors
- 👤 Wlodzimierz Gustowski
- 👤 Marian Kocor
- 👤 Chand K. Atal
- 👤 Alicja Orkiszewska
- 👤 Ryszard Olszewski
- 👤 Tadeusz Wrocinski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 05:02
CPC Classifications
A; A61; A61K; A61K36/00; A61K36/18; A61K36/185; A61K36/48; A61P; A61P13/00; A61P13/02; A61P15/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
53 words
Method of production of active substance of an antilithiatic medicament, characterized in that ground seeds of the genus Dolichos are extracted with polar solvents, then the extract is contingently submitted to acid hydrolysis, whereafter the acid hydrolyzate is contingently extracted with solvents immiscible with water, and then it is neutralized and contingently concentrated.
Claim 2
Dependent Claim
53 words
Method of production of active substance of an antilithiatic medicament, characterized in that ground seeds of the genus Dolichos are extracted with polar solvents, then the extract is contingently submitted to acid hydrolysis, whereafter the acid hydrolyzate is contingently extracted with solvents immiscible with water, and then it is neutralized and contingently concentrated.
Claim 3
Dependent Claim
23 words
Method as defined in claim 1, characterized in that ethers, esters, ketones, alcohols or water, or mixtures thereof are employed as polar solvents.
Claim 4
Dependent Claim
25 words
Method as defined in claim 2, characterized in that ethyl ether, ethyl acetate, acetone and alcohols having 1-5 carbon atoms are employed as polar solvents.
Claim 5
Dependent Claim
26 words
Methods as defined in claim 3, characterized in that polar organic solvents miscible with water are employed in a mixture with water in a facultative proportion.
Claim 6
Dependent Claim
18 words
Method as defined in claim 4, characterized in that a mixture of water with ethyl alcohol is employed.
Claim 7
Dependent Claim
30 words
Method as defined in claim 1, characterized in that the extraction of seeds is conducted within the temperature range of from room temperature to the boiling point of the solvent.
Claim 8
Dependent Claim
28 words
Method as defined in claim 1, characterized in that the acid hydrolysis of the extract is conducted with an organic or mineral acid having the concentration of 0.5-25%.
Claim 9
Dependent Claim
17 words
Method according to claim 7, wherein the organic or mineral acid is in the concentration of 1-5%.
Claim 10
Dependent Claim
37 words
Method as defined in claim 8, characterized in that sulphuric acid, hydrochloric acid, phosphoric acid, chloric acid, methane- or ethane-sulphonic acid, chlorinated acetic acid, citric acid, tartaric acid, propionic acid, lactic acid or mixtures thereof are employed.
Claim 11
Dependent Claim
19 words
Method as defined in claim 1, wherein the acid hydrolyzate is extracted with an organic solvent immiscible with water.
Claim 12
Dependent Claim
26 words
Method as defined in claim 10, wherein the extraction of the acid hydrolyzate is conducted by means of ethyl ether, ethyl acetate or a higher alcohol.
Claim 13
Dependent Claim
55 words
Method as defined in claim 1, characterized in that the hydrolysis is conducted with the temperature range from the room temperature to the boiling point of the reaction mixture, wherein the hydrolysis under the conditions of elevated temperature is conducted for 0.5-8 hours and the hydrolysis at the room temperature is conducted for 0.5-14 days.
Claim 14
Dependent Claim
30 words
Method as defined in claim 1, characterized in that the hydrolyzate is neutralized with a concentrated solution of sodium or potassium hydroxide or sodium or potassium carbonate or with ammonia.
Claim 15
Dependent Claim
27 words
A composition for the treatment of nephrolithiasis which comprises, as active ingredient, an antilithiatic agent prepared by the method of claim 1, and a pharmaceutically acceptable carrier.
Claim 16
Dependent Claim
24 words
A method of treating nephrolithiasis in patients by administering to said nephrolithiatic patients an antilithiatic amount of the composition as defined in claim 12.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-28 | 1982-11-27 | 1983-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-28 | 1986-11-27 | 1987-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-28 | 1990-11-27 | 1991-05-29 | $7700.00 | Window Closed / Lapsed |