US4845125A
Expired / Lapsed
US
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Chemolytic EDTA-citric acid composition for dissolution of calculi
Assignee: INDIANAPOLIS CENTER FOR ADVANCED RESEARCH Inc 611 NORTH CAPITOL AVENUE INDIANAPOLIS INDIANA 46204 A CORP OF
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Filing: 1987-11-10
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Granted: 1989-07-04
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Expires: 2007-11-10
Abstract
Abstract An improved composition for dissolution of renal calculi is disclosed. The composition includes citric acid, preferably at about 10 to about 15% by weight, and an effective amount of a pharmacologically acceptable chelating agent such as EDTA in a sterile aqueous solution having a pH between about 3 and about 4.5. In vivo irrigation with the improved formulation, optionally in combination with incident ultrasound therapy promotes rapid stone dissolution with minimal complications for the patient.
Inventors
- 👤 George E. Geier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:24
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
63 words
A chemolytic composition for in vivo dissolution of calculi comprising about 5 to about 20% citric acid or a pharmacologically acceptable salt thereof; and a chelating agent selected from the group consisting of ethylenediaminetetraacetic acid, N-(hydroxyethyl)ethylenediaminetriacetic acid and nitrilotriacetic acid at a concentration of at least about 0.05 M, in a sterile aqueous medium at a pH between about 3 and about 4.5.
Claim 2
Dependent Claim
63 words
A chemolytic composition for in vivo dissolution of calculi comprising about 5 to about 20% citric acid or a pharmacologically acceptable salt thereof; and a chelating agent selected from the group consisting of ethylenediaminetetraacetic acid, N-(hydroxyethyl)ethylenediaminetriacetic acid and nitrilotriacetic acid at a concentration of at least about 0.05 M, in a sterile aqueous medium at a pH between about 3 and about 4.5.
Claim 3
Dependent Claim
14 words
The chemolytic composition of claim 1 containing about 10 to about 15% citric acid.
Claim 4
Dependent Claim
13 words
The chemolytic composition of claim 2 wherein the chelating agent is ethylenediaminetetraacetic acid.
Claim 5
Dependent Claim
18 words
The chemolytic composition of claim 3 wherein the pH is adjusted to between about 3.5 and about 4.
Claim 6
Dependent Claim
20 words
A method of dissolving struvite kidney stones comprising contact said stones with a chemolytic composition in accordance with claim 4.
Claim 7
Dependent Claim
22 words
The method in accordance with claim 5 wherein the kidney stones are contacted with said compositions in the presence of incident ultrasound.
Claim 8
Dependent Claim
20 words
A method of dissolving struvite kidney stones comprising contacting said stones with a chemolytic composition with accordance with claim 4.
Claim 9
Dependent Claim
20 words
The method of claim 7 wherein the kidney stones are contacted with said composition in the presence of incident ultrasound.
Claim 10
Dependent Claim
20 words
A method of dissolving calculi (kidney stones) comprising contacting said stone with a chemolytic composition in accordance with claim 1.
Claim 11
Dependent Claim
20 words
The method of claim 9 wherein the kidney stones are contacted with said composition in the presence of incident ultrasound.
Claim 12
Dependent Claim
65 words
In a chemolytic stern aqueous solution adapted for dissolution of struvite kidney stones and containing citric acid, the improvement which comprises adjusting the concentration of said citric acid to about 10 to about 15% by weight of said solution and adding the chelating agent ethylenediaminetetraacetic acid to a concentration of about 0.05 to about 0.20 M, said solution having a pH between 3 and 4.5.
Claim 13
Dependent Claim
65 words
In a chemolytic stern aqueous solution adapted for dissolution of struvite kidney stones and containing citric acid, the improvement which comprises adjusting the concentration of said citric acid to about 10 to about 15% by weight of said solution and adding the chelating agent ethylenediaminetetraacetic acid to a concentration of about 0.05 to about 0.20 M, said solution having a pH between 3 and 4.5.
Claim 14
Dependent Claim
20 words
The improvement of claim 11 wherein the pH of the solution is adjusted to between about 3.5 and about 4.0.
Claim 15
Dependent Claim
23 words
The improvement of claim 12 wherein the citric acid concentration is about 12% by weight, and the EDTA concentration is about 0.1 M.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-03 | 1993-01-02 | 1993-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-03 | 1997-01-02 | 1997-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-03 | 2001-01-02 | 2001-07-04 | $7700.00 | Window Closed / Lapsed |