US6696073B2
Expired / Lapsed
US
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Shaped load-bearing osteoimplant and methods of making same
Assignee: Warsaw Orthopedic Inc
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Filing: 2002-08-27
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Granted: 2004-02-24
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Expires: 2022-08-27
Abstract
Abstract A load-bearing osteoimplant, methods of making the osteoimplant and method for repairing hard tissue such as bone and teeth employing the osteoimplant are provided. The osteoimplant comprises a shaped, coherent mass of bone particles which may exhibit osteogenic properties. In addition, the osteoimplant may possess one or more optional components which modify its mechanical and/or bioactive properties, e.g., binders, fillers, reinforcing components, etc.
Inventors
- 👤 Todd M. Boyce
- 👤 Lawrence Shimp
- 👤 Albert Manrique
- 👤 John M. Winterbottom
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:29
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/04; A61B17/0401; A61C; A61C8/00; A61C8/0012; A61C8/0018; A61C8/0036; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2/32; A61F2/46; A61F2/4644; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/3683; A61L27/3691; A61L27/38; A61L27/3839; A61L27/3843; A61L27/3847; A61L31/00; A61L31/005; A61B17/56; A61B17/58; A61B17/68; A61B17/72; A61B17/7291; A61B17/74; A61B17/742; A61B17/80; A61B17/84; A61B17/86; A61B2017/0409; A61B2017/0414; A61B2017/044; A61F2/2803; A61F2/2875; A61F2/3094; A61F2/30965; A61F2/34; A61F2/36; A61F2/44; A61F2/442; A61F2/4455; A61F2/446; A61F2/4603; A61F2/4611; A61F2002/2817; A61F2002/2825; A61F2002/2835; A61F2002/2871; A61F2002/2892; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30059; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/3011; A61F2002/30112; A61F2002/30113; A61F2002/30125; A61F2002/30138; A61F2002/30143; A61F2002/30146; A61F2002/30148; A61F2002/30153; A61F2002/30154; A61F2002/30158; A61F2002/30199; A61F2002/30224; A61F2002/30225; A61F2002/30235; A61F2002/30237; A61F2002/30261; A61F2002/30266; A61F2002/30316; A61F2002/30329; A61F2002/30433; A61F2002/30535; A61F2002/30561; A61F2002/30621; A61F2002/30622; A61F2002/30667; A61F2002/30677; A61F2/30767; A61F2/30771; A61F2002/30772; A61F2002/30784; A61F2002/30785; A61F2002/3085; A61F2002/3092; A61F2/30942; A61F2002/30948; A61F2002/30952; A61F2002/30957; A61F2002/30962; A61F2002/30968; A61F2/3609; A61F2002/3611; A61F2002/365; A61F2/3662; A61F2002/3678; A61F2002/3686; A61F2210/00; A61F2210/0004; A61F2220/00; A61F2220/0025; A61F2220/0041; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0006; A61F2230/0008; A61F2230/0017; A61F2230/0019; A61F2230/0021; A61F2230/0026; A61F2230/0063; A61F2230/0069; A61F2230/0082; A61F2250/00; A61F2250/0014; A61F2250/0058; A61F2250/0071; A61F2310/00; A61F2310/00005; A61F2310/00011; A61F2310/00161; A61F2310/00173; A61F2310/00179; A61F2310/00293; A61F2310/00347; A61F2310/00365; A61L2430/00; A61L2430/02; B; B33; B33Y; B33Y80/00
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
33 words
A load-bearing osteoimplant comprising a shaped, coherent mass of bone particles possessing a bulk density of greater than about 0.7 g/cm 3 and a wet compressive strength of at least about 3 MPa.
Claim 2
Dependent Claim
33 words
A load-bearing osteoimplant comprising a shaped, coherent mass of bone particles possessing a bulk density of greater than about 0.7 g/cm 3 and a wet compressive strength of at least about 3 MPa.
Claim 3
Dependent Claim
27 words
The osteoimplant of claim 1 wherein the bone particles are those of nondemineralized bone, substantially fully demineralized bone, partially demineralized bone, superficially demineralized bone or combinations thereof.
Claim 4
Dependent Claim
21 words
The osteoimplant of claim 1 wherein the bone particles are in the form of powders, chips, elongate particles or combinations thereof.
Claim 5
Dependent Claim
31 words
The osteoimplant of claim 1 wherein at least part of the bone particles possess surface exposed collagen, the bone particles being bonded by crosslinking of their mutually contacting exposed collagen surfaces.
Claim 6
Dependent Claim
38 words
The osteoimplant of claim 1 containing at least one additional component selected from the group consisting of binder, filler, coupling agent, plasticizer, wetting agent, surface active agent, biostatic/biocidal agent, bioactive substance, reinforcing material, reinforcing structure or combinations thereof.
Claim 7
Dependent Claim
19 words
The osteoimplant of claim 5 wherein the binder component is a natural, synthetic or semisynthetic bioresorbable or nonbioresorbable polymer.
Claim 8
Dependent Claim
107 words
The osteoimplant of claim 5 wherein the binder component is selected from the group consisting of fibrin glue, fibrinogen, thrombin, mussel adhesive protein, silk, elastin, collagen, casein, gelatin, albumin, keratin, chitin or chitosan; natural or modified polysaccharide, oxidized cellulose, genetically-engineered protein polymer; cyanoacrylate; epoxy-based compound; dental resin sealant; bioactive glass ceramic, dental resin cement; glass ionomer cement; gelatin-resorcinol-formaldehyde glue; collagen-based glue; polylactic acid; polyglycolic acid; polylactic-co-glycolic acid; polylactide, polyglycolide, poly(lactide-co-glycolide); polydioxanone; polycaprolactone; polycarbonate; polyorthoesters; polyamino acid; polyanhydride; polyhydroxybutyrate; polyhyroxyvalyrate; poly (propylene glycol-co-fumaric acid); tyrosine-based polycarbonate; pharmaceutical tablet binder; polyvinylpyrrolidone; cellulose; ethyl cellulose; micro-crystalline cellulose; starch; starch ethylenevinyl alcohol; polycyanoacrylate; polyphosphazene; polyacrylate; polymethyl methacrylate; polytetrafluoroethylene; polyurethane; and, polyamide.
Claim 9
Dependent Claim
59 words
The osteoimplant of claim 5 wherein the binder component is selected from the group consisting of amino acid-derived polycarbonate; amino acid-derived polyarylate; polyarylate derived from dicarboxylic acid and amino acid-derived diphenol; anionic polymer derived from L-tyrosine; polyarylate random block copolymer; polycarbonate; poly(-hydroycarboxylic acids); poly(caprolactone); poly(hydroxybutyrates); polyanhydrides; poly(ortho esters); polyester; bisphenol-A based poly(phosphoesters); and, copolymer of polyalkylene glycol and polyester.
Claim 10
Dependent Claim
30 words
The osteoimplant of claim 5 wherein the filler is selected from the group consisting of graphite, pyrolytic carbon, bioceramic, dentin tooth enamel, aragonite, calcite, inorganic nacre, calcium-containing compound and glass.
Claim 11
Dependent Claim
21 words
The osteoimplant of claim 9 wherein the inorganic calcium containing compound is hydroxyapatite, amorphous calcium phosphate, tricalcium phosphate or combinations thereof.
Claim 12
Dependent Claim
22 words
The osteoimplant of claim 5 wherein the biostatic/biocidal component is selected from the group consisting of vericide, antibiotic, povidone, sugar and mucopolysaccharide.
Claim 13
Dependent Claim
35 words
The osteoimplant of claim 11 wherein the antibiotic is selected from the group consisting of erythromycrin, bacitracin, neomycin, penicillin, polymycin B, tetracycline, biomycin, chloromycetin, and streptomycin, cefazolin, ampicillin, azactam, tobramycin, clindamycin, gentamicin and combinations thereof.
Claim 14
Dependent Claim
132 words
The osteoimplant of claim 5 wherein the bioactive substance is selected from the group consisting of collagen, insoluble collagen derivative; amino acid; peptide; vitamin; inorganic element; co-factor for protein synthesis; hormone; endocrine tissue or tissue fragment; synthesizer; enzyme; polymer cell scaffold with parenchymal cells; angiogenic agent; collagen lattice; antigenic agent; cytoskeletal agent; cartilage fragment; chondrocytes; bone marrow cells; mesenchymal stem cells; natural extract; modified living cells; DNA or DNA fragment; tissue transplant; autogenous tissue; bone morphogenic protein; osteoinductive factor; fibronectin; osteonectin; endothelial cell growth factor; cementum attachment extract; ketanserin, human growth hormone; animal growth hormone; epidermal growth factor; interleukin-1; human alpha thrombin; transforming growth factor; insulin-like growth factor; platelet derived growth factor; fibroblast growth factor; periodontal ligament chemotactic factor; somatotropin; bone digestor; antitumor agent; immuno-suppressant; permeation enhancer; nucleic acid; and, combinations thereof.
Claim 15
Dependent Claim
41 words
The osteoimplant of claim 5 wherein the reinforcing component is one or a combination of fiber, fibrous web, woven textile, nonwoven textile, mesh, nonflexible structural member or semiflexible structure member made from a natural, synthetic or semisynthetic nonbioresorbable or bioresorbable material.
Claim 16
Dependent Claim
37 words
The osteoimplant of claim 14 wherein the reinforcing component is oriented along the axis of the mechanical forces that can be expected to be exerted against the osteoimplant following its installation at a hard tissue repair site.
Claim 17
Dependent Claim
31 words
The osteoimplant of claim 15 configured as a sheet, plate, dish, cone, pin, screw, tube, tooth, tooth root, bone, bone portion, wedge, wedge portion, cylinder, dowel, intervertebral implant or suture anchor.
Claim 18
Dependent Claim
62 words
The osteoimplant of claim 15 configured as an anterior or posterior ramp or non-ramp intervertebral implant with substantially flat or lordotic surfaces, the implant being substantially solid or possessing at least one internal void structure or void network communicating with the surface of the implant, the void structure or void network being partially or completely filled with at least one bioactive substance.
Claim 19
Dependent Claim
14 words
The osteoimplant of claim 17 wherein the bioactive substance is a bone growth-promoting substance.
Claim 20
Dependent Claim
14 words
The osteoimplant of claim 19 wherein the bone growth-promoting substance contains demineralized bone powder.
Claim 21
Dependent Claim
31 words
The osteoimplant of claim 5 configured as a sheet, plate, dish, cone, pin, screw, tube, tooth, tooth root, bone, bone portion, wedge, wedge portion, cylinder, dowel, intervertebral implant or suture anchor.
Claim 22
Dependent Claim
62 words
The osteoimplant of claim 5 configured as an anterior or posterior ramp or non-ramp intervertebral implant with substantially flat or lordotic surfaces, the implant being substantially solid or possessing at least one internal void structure or void network communicating with the surface of the implant, the void structure or void network being partially or completely filled with at least one bioactive substance.
Claim 23
Dependent Claim
14 words
The osteoimplant of claim 21 wherein the bioactive substance is a bone growth-promoting substance.
Claim 24
Dependent Claim
14 words
The osteoimplant of claim 21 wherein the bone growth-promoting substance contains demineralized bone powder.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2007-02-23 | 2007-08-25 | 2008-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2011-02-23 | 2011-08-25 | 2012-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2015-02-23 | 2015-08-25 | 2016-02-24 | $7700.00 | Window Closed / Lapsed |