Implantable therapeutic device and method

Claim 2

For subsequently altering a biological activity of a medication in a localized area of a body after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; a first transducer coupled to a wall of said vascular graft; and an implantable circuit for receiving electromagnetic signals, said implantable circuit coupled to said first transducer, said first transducer configured to receive a first energy from said circuit to emit a second energy having one or more frequencies and power levels to alter said biological activity of said medication in said localized area of said body subsequent to implantation of said first transducer in said body near said localized area.

Claim 3

The vascular graft of claim 1 wherein said first transducer is selected from a group consisting of the following: an ultrasonic transducer, a plurality of light sources, an electric field transducer, an electromagnetic transducer, and a resistive heating transducer.

Claim 4

The vascular graft of claim 1 wherein said first transducer comprises a coil.

Claim 5

The vascular graft of claim 1 wherein said first transducer comprises a regular solid including piezoelectric material, and wherein a first resonance frequency, being of said one or more frequencies, is determined by a first dimension of said regular solid and a second resonance frequency, being of said one or more frequencies, is determined by a second dimension of said regular solid and further including a first electrode coupled to said regular solid and a second electrode coupled to said regular solid.

Claim 6

The vascular graft of claim 1 further comprising a second transducer coupled to said vascular graft, wherein said first and second transducers are coupled to said implantable electronic circuit and comprise ultrasonic transducers configured to provide acoustic standing waves having said one or more frequencies to alter said biological activity of said medication in a space between said first and second transducers in response to signals from said implantable electronic circuit.

Claim 7

The vascular graft of claim 1 further comprising a second transducer coupled to said vascular graft, wherein said first transducer is an ultrasonic transducer and said second transducer provides signals indicative of fluid flow through said vascular graft, said implantable circuit coupled to said second transducer.

Claim 8

The vascular graft of claim 1 wherein said implantable circuit includes a coil attached to a wall of said vascular graft and coupleable to a source of energy external to said body, to provide electrical power for energizing electrical components of said vascular graft.

Claim 9

The vascular graft of claim 7 wherein said coil is selected from a group consisting of the following: a cylindrical coil, a simple helix, a multiple helix, a woven mesh of insulated wire formed in a plurality of helices, a substantially spiral-like structure, and a saddle-shaped coil.

Claim 10

The vascular graft of claim 7 wherein said coil is generally saddle shaped and integrated into said wall, substantially conforming to a curvature of said wall about said longitudinal axis.

Claim 11

The vascular graft of claim 7 wherein said coil is adapted to electromagnetically couple to another coil that is connected to a source of energy.

Claim 12

The vascular graft of claim 1 further comprising a battery coupled to said implantable circuit.

Claim 13

For subsequently altering a biological activity of a medication in a localized area in a body after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an apparatus including a first coil, a signal source and a first control module, said first control module regulating coupling between said signal source and said first coil; one or more diagnostic transducers sized and constructed to be implanted into said body; and an implantable device including a second coil coupled to a therapeutic transducer, said first coil being aligned with said second coil such that said signal source is configured to supply electrical power to said implantable device to energize said therapeutic transducer, said therapeutic transducer configured to emit energy, when energized, having one or more frequencies and one or more power levels to alter the biological activity of the medication in the localized area in the body subsequent to implantation of said therapeutic transducer into the body near the localized area.

Claim 14

For subsequently altering a biological activity of a medication in a localized area in a body after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an apparatus including a first coil, a signal source and a first control module, said first control module regulating coupling between said signal source and said first coil; one or more diagnostic transducers sized and constructed to be implanted into said body; and an implantable device including a second coil coupled to a therapeutic transducer, said first coil being aligned with said second coil such that said signal source is configured to supply electrical power to said implantable device to energize said therapeutic transducer, said therapeutic transducer configured to emit energy, when energized, having one or more frequencies and one or more power levels to alter the biological activity of the medication in the localized area in the body subsequent to implantation of said therapeutic transducer into the body near the localized area.

Claim 15

The vascular graft of claim 12 , wherein said implantable device includes a second control module coupled to said therapeutic transducer, said second control module configured to receive control signals and to activate said therapeutic transducer in response to said control signals.

Claim 16

The vascular graft of claim 13 wherein said second control module is configured to supply signals to said one or more diagnostic transducers, to receive signals from said one or more diagnostic transducers indicative of fluid flow through said vascular graft and to supply signals to said first control module describing a condition of said vascular graft based on said signals received from said one or more diagnostic transducers.

Claim 17

The vascular graft of claim 12 wherein said therapeutic transducer is an ultrasonic transducer configured to emit ultrasound to alter the biological activity of the medication by insonification.

Claim 18

For subsequently altering a biological activity of a medication after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an implantable electronic circuit including a multiplexer; a therapeutic transducer coupled to said multiplexer, said therapeutic transducer configured to emit energy having one or more frequencies and one or more power levels to alter the biological activity of the medication in the localized area in the body subsequent to implantation of said therapeutic transducer into the body near the localized area; and a diagnostic transducer coupled to said multiplexer.

Claim 19

For subsequently altering a biological activity of a medication after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an implantable electronic circuit including a multiplexer; a therapeutic transducer coupled to said multiplexer, said therapeutic transducer configured to emit energy having one or more frequencies and one or more power levels to alter the biological activity of the medication in the localized area in the body subsequent to implantation of said therapeutic transducer into the body near the localized area; and a diagnostic transducer coupled to said multiplexer.

Claim 20

The vascular graft of claim 16 wherein said diagnostic transducer provides signals via said multiplexer to a RF modulator contained in said implantable electronic circuit for transmission via an implantable coil that is coupled to said implantable electronic circuit, wherein said diagnostic transducer is capable of providing signals indicative of a condition of fluid flow through said vascular graft.

Claim 21

The vascular graft of claim 17 , wherein said therapeutic transducer is an ultrasonic transducer configured to emit ultrasonic energy to alter the biological activity of the medication by insonification.

Claim 22

For subsequently releasing a medication encapsulated in a delivery vehicle into a localized area of a body after the encapsulated medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; a first transducer disposed within a wall of said vascular graft; and an implantable circuit for receiving electromagnetic signals, said implantable circuit coupled to said first transducer, said first transducer configured to receive a first energy from said implantable circuit to emit a second energy having one or more frequencies and power levels to rupture said delivery vehicle in said localized area thereby releasing said medication encapsulated in said delivery vehicle into said localized area of said body subsequent to implantation of said first transducer in said body near said localized area.

Claim 23

For subsequently releasing a medication encapsulated in a delivery vehicle into a localized area of a body after the encapsulated medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; a first transducer disposed within a wall of said vascular graft; and an implantable circuit for receiving electromagnetic signals, said implantable circuit coupled to said first transducer, said first transducer configured to receive a first energy from said implantable circuit to emit a second energy having one or more frequencies and power levels to rupture said delivery vehicle in said localized area thereby releasing said medication encapsulated in said delivery vehicle into said localized area of said body subsequent to implantation of said first transducer in said body near said localized area.

Claim 24

The vascular graft of claim 19 wherein said first transducer is selected from a group consisting of the following: an ultrasonic transducer, a plurality of light sources, an electric field transducer, an electromagnetic transducer, and a resistive heating transducer.

Claim 25

The vascular graft of claim 19 wherein said first transducer comprises a coil.

Claim 26

The vascular graft of claim 19 wherein said first transducer comprises a regular solid including piezoelectric material, and wherein a first resonance frequency, being of the one or more frequencies, is determined by a first dimension of said regular solid and a second resonance frequency, being of the one or more frequencies, is determined by a second dimension of said regular solid, and further including a first electrode coupled to said regular solid and a second electrode coupled to said regular solid.

Claim 27

The vascular graft of claim 19 , further comprising a second transducer coupled to said vascular graft, wherein said first and second transducers are coupled to said implantable circuit and comprise ultrasonic transducers configured to provide acoustic standing waves having the one or more frequencies to rupture the delivery vehicle in a space between said first and second transducers in response to signals from said implantable circuit.

Claim 28

The vascular graft of claim 19 , further comprising a second transducer coupled to said vascular graft, wherein said first transducer is an ultrasonic transducer and said second transducer provides signals indicative of fluid flow through said vascular graft, said implantable circuit coupled to said second transducer.

Claim 29

The vascular graft of claim 19 wherein said implantable circuit includes a coil attached to a wall of said vascular graft and coupleable to a source of energy external to said body, to provide electrical power for energizing electrical components of said vascular graft.

Claim 30

The vascular graft of claim 25 wherein said coil is selected from a group consisting of the following: a cylindrical coil, a simple helix, a multiple helix, a woven mesh of insulated wire formed in a plurality of helices, a substantially spiral-like structure, and a saddle-shaped coil.

Claim 31

The vascular graft of claim 25 wherein said coil is generally saddle shaped and integrated into said wall, substantially conforming to a curvature of said wall about said longitudinal axis.

Claim 32

The vascular graft of claim 25 wherein said coil is adapted to electromagnetically couple to another coil that is connected to a source of energy.

Claim 33

The vascular graft of claim 19 further comprising a battery coupled to said implantable circuit.

Claim 34

For subsequently releasing a medication encapsulated in a delivery vehicle into a localized area of a body after the encapsulated medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an apparatus including a first coil, a signal source and a first control module, said first control module regulating coupling between said signal source and said first coil; one or more diagnostic transducers sized and constructed to be implanted into said body; and an implantable device including a second coil coupled to a therapeutic transducer, said first coil aligned with said second coil such that said signal source is configured to supply electrical power to said implantable device to energize said therapeutic transducer, said therapeutic transducer configured to emit energy, when energized, having one or more frequencies and one or more power levels to rupture said delivery vehicle in said localized area thereby releasing said medication encapsulated in said delivery vehicle into said localized area of said body subsequent to implantation of said first transducer in said body near said localized area.

Claim 35

For subsequently releasing a medication encapsulated in a delivery vehicle into a localized area of a body after the encapsulated medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an apparatus including a first coil, a signal source and a first control module, said first control module regulating coupling between said signal source and said first coil; one or more diagnostic transducers sized and constructed to be implanted into said body; and an implantable device including a second coil coupled to a therapeutic transducer, said first coil aligned with said second coil such that said signal source is configured to supply electrical power to said implantable device to energize said therapeutic transducer, said therapeutic transducer configured to emit energy, when energized, having one or more frequencies and one or more power levels to rupture said delivery vehicle in said localized area thereby releasing said medication encapsulated in said delivery vehicle into said localized area of said body subsequent to implantation of said first transducer in said body near said localized area.

Claim 36

The vascular graft of claim 30 , wherein said implantable device includes a second control module coupled to said therapeutic transducer, said second control module capable to receive control signals and to activate said therapeutic transducer in response to said control signals.

Claim 37

The vascular graft of claim 31 wherein said second control module is configured to supply signals to said one or more diagnostic transducers, to receive signals from said one or more diagnostic transducers indicative of fluid flow through said vascular graft and to supply signals to said first control module describing a condition of said vascular graft based on said signals received from said one or more diagnostic transducers.

Claim 38

The vascular graft of claim 30 wherein said therapeutic transducer is an ultrasonic transducer configured to emit ultrasonic energy to rupture said delivery vehicle.

Claim 39

For subsequently releasing a medication encapsulated in a delivery vehicle into a localized area of a body after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an implantable electronic circuit including a multiplexer; and a therapeutic transducer coupled to said multiplexer, said therapeutic transducer configured to emit energy having one or more frequencies and one or more power levels to rupture said delivery vehicle in the localized area thereby releasing the medication encapsulated in said delivery vehicle into said localized area of said body subsequent to implantation of said therapeutic transducer in said body near said localized area.

Claim 40

For subsequently releasing a medication encapsulated in a delivery vehicle into a localized area of a body after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an implantable electronic circuit including a multiplexer; and a therapeutic transducer coupled to said multiplexer, said therapeutic transducer configured to emit energy having one or more frequencies and one or more power levels to rupture said delivery vehicle in the localized area thereby releasing the medication encapsulated in said delivery vehicle into said localized area of said body subsequent to implantation of said therapeutic transducer in said body near said localized area.

Claim 41

The vascular graft of claim 34 , further comprising a diagnostic transducer wherein said diagnostic transducer provides signals via said multiplexer to a RF modulator contained in said implantable electronic circuit for transmission via an implantable coil that is coupled to said implantable electronic circuit, wherein said diagnostic transducer is capable of providing signals indicative of a condition of fluid flow through said vascular graft.

Claim 42

The vascular graft of claim 35 , wherein said therapeutic transducer is an ultrasonic transducer configured to emit ultrasonic energy to rupture said delivery vehicle.

Claim 43

For subsequently altering a biological response to a medication in a localized area of a body after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; a first transducer disposed within a wall of said vascular graft; and an implantable circuit for receiving electromagnetic signals, said implantable circuit coupled to said first transducer, said first transducer configured to receive a first energy from said implantable circuit to emit a second energy having one or more frequencies and power levels to alter said biological response to said medication of said portion of said body in said localized area of said body subsequent to implantation of said first transducer in said body near said localized area.

Claim 44

For subsequently altering a biological response to a medication in a localized area of a body after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; a first transducer disposed within a wall of said vascular graft; and an implantable circuit for receiving electromagnetic signals, said implantable circuit coupled to said first transducer, said first transducer configured to receive a first energy from said implantable circuit to emit a second energy having one or more frequencies and power levels to alter said biological response to said medication of said portion of said body in said localized area of said body subsequent to implantation of said first transducer in said body near said localized area.

Claim 45

The vascular graft of claim 37 wherein said first transducer is selected from a group consisting of the following: an ultrasonic transducer, a plurality of light sources, an electric field transducer, an electromagnetic transducer, and a resistive heating transducer.

Claim 46

The vascular graft of claim 37 wherein said first transducer comprises a coil.

Claim 47

The vascular graft of claim 37 wherein said first transducer comprises a regular solid including piezoelectric material, and wherein a first resonance frequency, being of the one or more frequencies, is determined by a first dimension of said regular solid and a second resonance frequency, being of the one or more frequencies, is determined by a second dimension of said regular solid, and further including a first electrode coupled to said regular solid and a second electrode coupled to said regular solid.

Claim 48

The vascular graft of claim 37 further comprising a second transducer coupled to said vascular graft, wherein said first and second transducers are coupled to said implantable circuit and comprise ultrasonic transducers configured to provide acoustic standing waves having the one or more frequencies to alter said biological activity in a space between said first and second transducers in response to signals from said implantable circuit.

Claim 49

The vascular graft of claim 37 , further comprising a second transducer coupled to said vascular graft, wherein said first transducer is an ultrasonic transducer and said second transducer provides signals indicative of fluid flow through said vascular graft, said implantable circuit coupled to said second transducer.

Claim 50

The vascular graft of claim 37 wherein said implantable circuit includes a coil attached to a wall of said vascular graft and coupleable to a source of energy external to said body, to provide electrical power for energizing electrical components of said vascular graft.

Claim 51

The vascular graft of claim 43 wherein said coil is selected from a group consisting of the following: a cylindrical coil, a simple helix, a multiple helix, a woven mesh of insulated wire formed in a plurality of helices, a substantially spiral-like structure, and a saddle-shaped coil.

Claim 52

The vascular graft of claim 43 wherein said coil is generally saddle shaped and integrated into said wall, substantially conforming to a curvature of said wall about said longitudinal axis.

Claim 53

The vascular graft of claim 43 wherein said coil is adapted to electromagnetically couple to another coil that is connected to a source of energy.

Claim 54

The vascular graft of claim 37 further comprising a battery coupled to said implantable circuit.

Claim 55

For subsequently altering a biological response to a medication in a localized area of a body after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an apparatus including a first coil, a signal source and a first control module, said first control module regulating coupling between said signal source and said first coil; one or more diagnostic transducers coupled to a vascular graft sized and constructed to be implanted into said body; and an implantable device including a second coil coupled to a therapeutic transducer said first coil being aligned with said second coil such that said signal source is configured to supply electrical power to said implantable device to energize said therapeutic transducer, said therapeutic transducer configured to emit energy, when energized, having one or more frequencies and one or more power levels to alter said biological response to said medication of said portion of said body in said localized area in said body subsequent to implantation of said therapeutic transducer in said body near said localized area.

Claim 56

For subsequently altering a biological response to a medication in a localized area of a body after the medication had been introduced intravascularly into the body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an apparatus including a first coil, a signal source and a first control module, said first control module regulating coupling between said signal source and said first coil; one or more diagnostic transducers coupled to a vascular graft sized and constructed to be implanted into said body; and an implantable device including a second coil coupled to a therapeutic transducer said first coil being aligned with said second coil such that said signal source is configured to supply electrical power to said implantable device to energize said therapeutic transducer, said therapeutic transducer configured to emit energy, when energized, having one or more frequencies and one or more power levels to alter said biological response to said medication of said portion of said body in said localized area in said body subsequent to implantation of said therapeutic transducer in said body near said localized area.

Claim 57

The vascular graft of claim 48 , wherein said implantable device includes a second control module coupled to said therapeutic transducer, said second control module capable to receive control signals and to activate said therapeutic transducer in response to said control signals.

Claim 58

The vascular graft of claim 49 wherein said second control module is configured to supply signals to said one or more diagnostic transducers, to receive signals from said one or more diagnostic transducers indicative of fluid flow through said vascular graft and to supply signals to said first control module describing a condition of said vascular graft based on said signals received from said one or more diagnostic transducers.

Claim 59

The vascular graft of claim 48 wherein said therapeutic transducer is an ultrasonic transducer configured to emit ultrasonic energy to alter said biological response to said medication.

Claim 60

For altering a biological response to a medication of a portion of a body in a localized area of said body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an implantable electronic circuit including a multiplexer; a therapeutic transducer coupled to said multiplexer, said therapeutic transducer configured to emit energy having one or more frequencies and one or more power levels to alter said biological response to said medication of said portion of said body in said localized area of said body subsequent to implantation of said therapeutic transducer into said body near said localized area; a diagnostic transducer coupled to said multiplexer; and a vascular graft coupled to said diagnostic transducer.

Claim 61

For altering a biological response to a medication of a portion of a body in a localized area of said body, a vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; an implantable electronic circuit including a multiplexer; a therapeutic transducer coupled to said multiplexer, said therapeutic transducer configured to emit energy having one or more frequencies and one or more power levels to alter said biological response to said medication of said portion of said body in said localized area of said body subsequent to implantation of said therapeutic transducer into said body near said localized area; a diagnostic transducer coupled to said multiplexer; and a vascular graft coupled to said diagnostic transducer.

Claim 62

The vascular graft of claim 52 wherein said diagnostic transducer provides signals via said multiplexer to a RF modulator contained in said implantable electronic circuit for transmission via an implantable coil that is coupled to said implantable electronic circuit, wherein said diagnostic transducer is capable of providing signals indicative of a condition of fluid flow through said vascular graft.

Claim 63

The vascular graft of claim 53 , wherein said therapeutic transducer is an ultrasonic transducer configured to emit ultrasonic energy to alter said biological response to said medication of said portion of said body.

Claim 64

A vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; a first transducer coupled to a wall of said vascular graft; and an implantable circuit for receiving electromagnetic signals, said implantable circuit coupled to said first transducer, said first transducer configured to receive a first energy from said circuit to emit a second energy having one or more frequencies and power levels to subsequently alter a biological activity of a medication in a localized area of a body after the medication had been introduced intravascularly into said body, subsequent to implantation of said first transducer in said body near said localized area.

Claim 65

A vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; a first transducer coupled to a wall of said vascular graft; and an implantable circuit for receiving electromagnetic signals, said implantable circuit coupled to said first transducer, said first transducer configured to receive a first energy from said circuit to emit a second energy having one or more frequencies and power levels to subsequently alter a biological activity of a medication in a localized area of a body after the medication had been introduced intravascularly into said body, subsequent to implantation of said first transducer in said body near said localized area.

Claim 66

A vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; a first transducer disposed within a wall of said vascular graft; and an implantable circuit for receiving electromagnetic signals, said implantable circuit coupled to said first transducer, said first transducer configured to receive a first energy from said implantable circuit to emit a second energy having one or more frequencies and power levels to subsequently rupture a delivery vehicle containing an encapsulated medication in a localized area of a body after the encapsulated medication had been introduced intravascularly into said body, to release said encapsulated medication into said localized area of said body, subsequent to implantation of said first transducer in said body near said localized area.

Claim 67

A vascular graft comprising: a biocompatible material formed into a shape having a longitudinal axis to enclose a lumen disposed along said longitudinal axis of said shape, said lumen positioned to convey fluid through said vascular graft; a first transducer disposed within a wall of said vascular graft; and an implantable circuit for receiving electromagnetic signals, said implantable circuit coupled to said first transducer, said first transducer configured to receive a first energy from said implantable circuit to emit a second energy having one or more frequencies and power levels to subsequently rupture a delivery vehicle containing an encapsulated medication in a localized area of a body after the encapsulated medication had been introduced intravascularly into said body, to release said encapsulated medication into said localized area of said body, subsequent to implantation of said first transducer in said body near said localized area.