US5490840A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Targeted thermal release of drug-polymer conjugates
Assignee: Insightec Ltd
•
Filing: 1994-09-26
•
Granted: 1996-02-13
•
Expires: 2014-09-26
Abstract
Abstract Thermal drug treatment of tumor tissue is obtained by attaching a thermally active drug to carrier molecules which have an affinity to tumor tissue. Localized heating is performed on the tumor tissue, thereby activating the drug in the tumor tissue. The end result may be concentrated delivery of a drug to a chosen tissue, or, in the case where the drug creates a toxin when heated, selective tissue destruction of a selected locations heated. The localized heat may be applied by focused ultrasound heating.
Inventors
- 👤 Egidijus E. Uzgiris
- 👤 Lorinda R. Opsahl
- 👤 Kirby G. Vosburgh
- 👤 Thomas R. Anthony
- 👤 Harvey E. Cline
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 15:13
CPC Classifications
A; A61; A61M; A61M37/00; A61M37/0092
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
143 words
A method of thermal drug treatment of tumor tissue of a subject comprising the steps of: a) selecting drug molecules used in tumor tissue treatment of living subjects; b) selecting a polypeptide carrier molecule of a size such that it will pass freely into tumor tissue but substantially none will pass into normal tissue; c) binding drug molecules to carrier molecules to result in combined carrier/drug molecules; d) introducing the carrier/drug molecules into a blood vessel of said subject having said tumor tissue desired to be destroyed causing the carrier/drug molecules to infuse into the tumor tissue; and e) heating the tumor tissue employing focused ultrasound and the carrier/drug molecules within the tumor tissue to cause the carrier/drug molecules to produce a toxin having a relatively increased concentration in the tumor tissue as compared with the concentration in other tissues of said subject.
Claim 2
Independent Claim
143 words
A method of thermal drug treatment of tumor tissue of a subject comprising the steps of: a) selecting drug molecules used in tumor tissue treatment of living subjects; b) selecting a polypeptide carrier molecule of a size such that it will pass freely into tumor tissue but substantially none will pass into normal tissue; c) binding drug molecules to carrier molecules to result in combined carrier/drug molecules; d) introducing the carrier/drug molecules into a blood vessel of said subject having said tumor tissue desired to be destroyed causing the carrier/drug molecules to infuse into the tumor tissue; and e) heating the tumor tissue employing focused ultrasound and the carrier/drug molecules within the tumor tissue to cause the carrier/drug molecules to produce a toxin having a relatively increased concentration in the tumor tissue as compared with the concentration in other tissues of said subject.
Claim 3
Dependent Claim
41 words
The method of thermal drug treatment of claim 1 wherein the polypeptide carrier molecules are chosen to have a plurality of residues such that the combined charge of molecules of the selected polypeptide and selected drug is a net negative charge.
Claim 4
Dependent Claim
30 words
The method of thermal drug treatment of claim 1 wherein the polypeptide carrier molecules and drug molecules have a combined molecular size chosen to selectively accumulate in the tumor tissue.
Claim 5
Dependent Claim
26 words
The method of thermal drug treatment of claim 1 wherein the polypeptide carrier molecules are selected to be polylysine molecules having a plurality of attached residues.
Claim 6
Dependent Claim
18 words
The method of thermal drug treatment of claim 1 wherein the drugs are chosen to be chemotherapy drugs.
References Cited (Backward Citations)
US5145863A
Cited
US4925922A
Cited
USRE33590E
Cited
US4771130A
Cited
US4822335A
Cited
US5163898A
Cited
US4960408A
Cited
US5230883A
Cited
US5016615A
Cited
US5216126A
Cited
US5247935A
Cited
US5275165A
Cited
US5370120A
Cited
US5307812A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-02-12 | 1999-08-14 | 2000-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-02-12 | 2003-08-14 | 2004-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-02-12 | 2007-08-14 | 2008-02-13 | $7700.00 | Window Closed / Lapsed |