Patent US6505059B1 successfully refreshed from Google Patents.
US6505059B1
Expired / Lapsed
US
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Non-invasive tissue glucose level monitoring
Assignee: General Hospital Corp
•
Filing: 1999-04-06
•
Granted: 2003-01-07
•
Expires: 2019-04-06
Abstract
Abstract Instruments and methods for performing non-invasive measurements of analyte concentrations and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.
Inventors
- 👤 Nikiforos Kollias
- 👤 Wei Dong Tian
- 👤 Jenny E. Freeman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 14:26
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/0059; A61B5/0071; A61B5/14532
Claims Analysis
Total Claims: 74
Claim 1
Independent Claim
92 words
A non-invasive glucose monitoring instrument comprising: a radiation source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient wherein said target is a tissue component; a radiation detector positioned to receive fluorescent radiation emitted from an excited target; and a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.
Claim 2
Dependent Claim
92 words
A non-invasive glucose monitoring instrument comprising: a radiation source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient wherein said target is a tissue component; a radiation detector positioned to receive fluorescent radiation emitted from an excited target; and a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.
Claim 3
Dependent Claim
14 words
The instrument of claim 1 wherein the -radiation source is an ultraviolet light source.
Claim 4
Dependent Claim
21 words
The instrument of claim 1 further including a flexible-fiber optic arm that is capable of directing said radiation to the target.
Claim 5
Dependent Claim
14 words
The instrument of claim 3 wherein the probe comprises a glass or quartz fiber.
Claim 6
Dependent Claim
21 words
The instrument of claim 1 wherein the portion of the tissue surface is a portion of the skin of a patient.
Claim 7
Dependent Claim
18 words
The instrument of claim 5 wherein the portion of skin irradiated is less than about 1 square cm.
Claim 8
Dependent Claim
16 words
The instrument of claim 5 wherein the portion of skin irradiated is about 0.2 square cm.
Claim 9
Dependent Claim
11 words
The instrument of claim 5 wherein the portion of-skin is pigmented.
Claim 10
Dependent Claim
13 words
The instrument of claim 1 wherein the excitation wavelength is about 295 nm.
Claim 11
Dependent Claim
14 words
The instrument of claim 1 wherein the excitation wavelength is between about 335-340 nm.
Claim 12
Dependent Claim
13 words
The instrument of claim 1 wherein the target is a structural matrix component.
Claim 13
Dependent Claim
12 words
The instrument of claim 1 wherein the target is a collagen cross-link.
Claim 14
Dependent Claim
16 words
The instrument of claim 1 wherein the target is a pepsin-digestible or a collagenase-digestible collagen cross-link.
Claim 15
Dependent Claim
10 words
The instrument of claim 1 wherein the target is tryptophan.
Claim 16
Dependent Claim
37 words
The instrument of claim 1 wherein the radiation source is operative to emit radiation at between about 285 and 305 nm and the radiation detector is operative to detect radiation at between about 315 and 420 nm.
Claim 17
Dependent Claim
37 words
The instrument of claim 1 wherein the radiation source is operative to emit radiation at between about 330 and 345 nm and the radiation detector is operative to detect radiation at between about 370 and 410 nm.
Claim 18
Dependent Claim
12 words
The instrument of claim 1 which weighs less than about 0.5 kilograms.
Claim 19
Dependent Claim
24 words
The instrument of claim 1 further comprising a display operatively connected to the processing circuit that is operative to display said glucose level indication.
Claim 20
Dependent Claim
34 words
The instrument of claim 1 further comprising an insulin pump responsive to the processing circuit that is operative to administer insulin to a patient at a rate that corresponds to the glucose level signal.
Claim 21
Dependent Claim
21 words
The instrument of claim 19 wherein the detector, processing circuit, insulin pump and the patient form part of a servo loop.
Claim 22
Dependent Claim
48 words
The instrument of claim 1 further comprising an alarm means operationally coupled to the processing circuit wherein the alarm means is activated when the glucose level indication exceeds a first predetermined value, falls below a second predetermined value or varies more than 20% from a third predetermined value.
Claim 23
Dependent Claim
28 words
The instrument of claim 1 further comprising a normalizing detector responsive to another target that provides normalizing information to said processing circuit to normalize the glucose level indication.
Claim 24
Dependent Claim
23 words
The instrument of claim 1 further comprising normalizing means which provides normalizing information to said processing circuit to normalize the glucose level indication.
Claim 25
Dependent Claim
11 words
The instrument of claim 1 further comprising means for measuring scattering.
Claim 26
Dependent Claim
28 words
The instrument of claim 24 wherein the means for measuring scattering comprises an illuminating means that emits radiation at an angle greater than 60 degrees to said target.
Claim 27
Dependent Claim
25 words
The instrument of claim 24 wherein the means for measuring scattering comprises an illuminating means which emits radiation at between about 330 to 420 nm.
Claim 28
Dependent Claim
27 words
The instrument of claim 1 further comprising a portable housing and wherein the radiation source, the radiation detector and the processing circuit are disposed in the housing.
Claim 29
Dependent Claim
33 words
The instrument of claim 27 further comprising a battery compartment disposed in the housing and a pair of battery contacts operatively connected to the radiation source, the radiation detector. and the processing circuit.
Claim 30
Dependent Claim
18 words
The instrument of claim 1 further comprising an attachment means for attaching the radiation source to the patient.
Claim 31
Dependent Claim
9 words
The instrument of claim 1 further comprising a transmitter.
Claim 32
Dependent Claim
93 words
A disposable non-invasive glucose monitoring instrument comprising: a radiation source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient wherein said target is a tissue component; a radiation detector positioned to receive fluorescent radiation emitted from an excited target; and a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.
Claim 33
Dependent Claim
93 words
A disposable non-invasive glucose monitoring instrument comprising: a radiation source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient wherein said target is a tissue component; a radiation detector positioned to receive fluorescent radiation emitted from an excited target; and a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.
Claim 34
Dependent Claim
54 words
A non-invasive method of detecting a glucose level comprising: exciting a non-glucose target wherein the excited target is indicative of a glucose level of a patient and said target is a tissue component; detecting an amount of fluorescent radiation emitted by the target; and determining said glucose level from the amount of radiation detected.
Claim 35
Dependent Claim
54 words
A non-invasive method of detecting a glucose level comprising: exciting a non-glucose target wherein the excited target is indicative of a glucose level of a patient and said target is a tissue component; detecting an amount of fluorescent radiation emitted by the target; and determining said glucose level from the amount of radiation detected.
Claim 36
Dependent Claim
13 words
The method of claim 32 wherein the target is excited with electromagnetic radiation.
Claim 37
Dependent Claim
11 words
The method of claim 32 wherein the radiation is ultraviolet radiation.
Claim 38
Dependent Claim
16 words
The method of claim 33 wherein the radiation is at a wavelength of about 295 nm.
Claim 39
Dependent Claim
16 words
The method of claim 32 wherein the radiation is at a wavelength of about 335-340 nm.
Claim 40
Dependent Claim
12 words
The method of claim 32 wherein the target is a collagen cross-link.
Claim 41
Dependent Claim
18 words
The method of claim 32 wherein the target is a pepsin digestible or a collagenase digestible collagen cross-link.
Claim 42
Dependent Claim
10 words
The method of claim 32 wherein the target is tryptophan.
Claim 43
Dependent Claim
20 words
The method of claim 32 wherein the radiation detected from the excited target is between about 340 and 400 nm.
Claim 44
Dependent Claim
21 words
The method of claim 32 further comprising adjusting the glucose level of the patient in response to the glucose level determined.
Claim 45
Dependent Claim
12 words
The method of claim 32 further comprising administering insulin to the patient.
Claim 46
Dependent Claim
14 words
The method of claim 42 wherein insulin is administered with a biodelivery system. .
Claim 47
Dependent Claim
13 words
The method of claim 43 wherein the biodelivery system includes an insulin pump.
Claim 48
Dependent Claim
18 words
The method of claim 32 wherein the glucose level is remotely transmitted to a monitor or servo mechanism.
Claim 49
Dependent Claim
12 words
The method of claim 32 further comprising normalizing the glucose level determined.
Claim 50
Dependent Claim
41 words
The method of claim 32 further comprising actuating an alarm in response to the glucose level when said glucose level exceeds a predetermined first level, falls below a predetermined second level or varies more than 20% from a predetermined third level.
Claim 51
Dependent Claim
14 words
The method of claim 32 further comprising measuring scattering and adjusting the glucose level.
Claim 52
Dependent Claim
85 words
A non-invasive glucose monitoring instrument comprising: an ultraviolet light source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient; a radiation detector positioned to receive radiation emitted from an excited target; and a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.
Claim 53
Dependent Claim
85 words
A non-invasive glucose monitoring instrument comprising: an ultraviolet light source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient; a radiation detector positioned to receive radiation emitted from an excited target; and a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.
Claim 54
Dependent Claim
24 words
The non-invasive glucose monitoring instrument of claim 49 wherein the target is located in a dermal region or an epidermal region of said body.
Claim 55
Dependent Claim
52 words
The non-invasive glucose monitoring instrument of claim 49 wherein the target is selected from the group consisting of a structural matrix component, a dermal matrix component, an epidermal matrix component, collagen, glycated collagen, glycosaminoglycans, elastin, glycosylated substances in a tissue, a pepsin-digestible cross link, a collagenase-digestible cross link, tryptophan and combinations thereof.
Claim 56
Dependent Claim
17 words
The non-invasive glucose monitoring instrument of claim 49 wherein the target emits radiation at between 315-420 nanometers.
Claim 57
Dependent Claim
128 words
A non-invasive glucose monitoring instrument comprising: a radiation source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient wherein the target is selected from the group consisting of a structural matrix component, a dermal matrix component, an epidermal matrix component, collagen, glycated collagen, glycosaminoglycans, elastin, glycosylated substances in a tissue, a pepsin-digestible cross link, a collagenase-digestible cross link, tryptophan and combinations thereof; a radiation detector positioned to receive radiation emitted from an excited target; and a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.
Claim 58
Dependent Claim
128 words
A non-invasive glucose monitoring instrument comprising: a radiation source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient wherein the target is selected from the group consisting of a structural matrix component, a dermal matrix component, an epidermal matrix component, collagen, glycated collagen, glycosaminoglycans, elastin, glycosylated substances in a tissue, a pepsin-digestible cross link, a collagenase-digestible cross link, tryptophan and combinations thereof; a radiation detector positioned to receive radiation emitted from an excited target; and a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.
Claim 59
Dependent Claim
18 words
The non-invasive glucose monitoring instrument of claim 53 wherein the target emits radiation at between about 315-420 nanometers.
Claim 60
Dependent Claim
17 words
The non-invasive glucose monitoring instrument of claim 53 wherein the radiation source is an ultraviolet light source.
Claim 61
Dependent Claim
51 words
A non-invasive method of detecting a glucose level comprising: exciting a non-glucose target with an ultraviolet light source wherein the excited target is indicative of a glucose level of a patient; detecting an amount of radiation emitted by the target; and determining said glucose level from the amount of radiation detected.
Claim 62
Dependent Claim
51 words
A non-invasive method of detecting a glucose level comprising: exciting a non-glucose target with an ultraviolet light source wherein the excited target is indicative of a glucose level of a patient; detecting an amount of radiation emitted by the target; and determining said glucose level from the amount of radiation detected.
Claim 63
Dependent Claim
15 words
The method of claim 56 wherein the target emits radiation at between about 315-420 nanometers.
Claim 64
Dependent Claim
49 words
The method of claim 56 wherein the target is selected from the group consisting of a structural matrix component, a dermal matrix component, an epidermal matrix component, collagen, glycated collagen, glycosaminoglycans, elastin, glycosylated substances in a tissue, a pepsin-digestible cross link, a collagenase-digestible cross link, tryptophan and combinations thereof.
Claim 65
Dependent Claim
90 words
A non-invasive method of detecting a glucose level comprising: exciting a non-glucose target wherein the excited target is indicative of a glucose level of a patient and the target is selected from the group consisting of a structural matrix component, a dermal matrix component, an epidermal matrix component, collagen, glycated collagen, glycosaminoglycans, elastin, glycosylated substances in a tissue, a pepsin-digestible cross link, a collagenase-digestible cross link, tryptophan and combinations thereof; detecting an amount of radiation emitted by the target; and determining said glucose level from the amount of radiation detected.
Claim 66
Dependent Claim
90 words
A non-invasive method of detecting a glucose level comprising: exciting a non-glucose target wherein the excited target is indicative of a glucose level of a patient and the target is selected from the group consisting of a structural matrix component, a dermal matrix component, an epidermal matrix component, collagen, glycated collagen, glycosaminoglycans, elastin, glycosylated substances in a tissue, a pepsin-digestible cross link, a collagenase-digestible cross link, tryptophan and combinations thereof; detecting an amount of radiation emitted by the target; and determining said glucose level from the amount of radiation detected.
Claim 67
Dependent Claim
15 words
The method of claim 59 wherein the target emits radiation at between about 315-420 nanometers.
Claim 68
Dependent Claim
49 words
The method of claim 59 wherein the target is selected from the group consisting of a structural matrix component, a dermal matrix component, an epidermal matrix component, collagen, glycated collagen, glycosaminoglycans, elastin, glycosylated substances in a tissue, a pepsin-digestible cross link, a collagenase-digestible cross link, tryptophan and combinations thereof.
Claim 69
Dependent Claim
14 words
The method of claim 59 wherein the non-glucose target is excited with ultraviolet light.
Claim 70
Dependent Claim
51 words
A non-invasive method of detecting a glucose level of a patient comprising: exciting a fluorophore in vivo with electromagnetic radiation wherein the excited fluorophore provides an indication of said glucose level; detecting an amount of radiation emitted by the fluorophore; and determining said glucose level from the amount of radiation detected.
Claim 71
Dependent Claim
51 words
A non-invasive method of detecting a glucose level of a patient comprising: exciting a fluorophore in vivo with electromagnetic radiation wherein the excited fluorophore provides an indication of said glucose level; detecting an amount of radiation emitted by the fluorophore; and determining said glucose level from the amount of radiation detected.
Claim 72
Dependent Claim
15 words
The method of claim 63 wherein the fluorophore emits radiation at between about 315-420 nanometers.
Claim 73
Dependent Claim
49 words
The method of claim 63 wherein the fluorophore is selected from the group consisting of a structural matrix component, a dermal matrix component, an epidermal matrix component, collagen, glycated collagen, glycosaminoglycans, elastin, glycosylated substances in a tissue, a pepsin-digestible cross link, a collagenase-digestible cross link, tryptophan and combinations thereof.
Claim 74
Dependent Claim
12 words
The method of claim 63 wherein the electromagnetic radiation comprises ultraviolet light.
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