US5368028A
Expired / Lapsed
US
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System for monitoring and controlling blood and tissue constituent levels
Assignee: CB-CARMEL BIOTECHNOLOGY Ltd
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Filing: 1993-06-16
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Granted: 1994-11-29
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Expires: 2013-06-16
Abstract
Abstract Systems are disclosed which utilize implanted chemo-sensitive living cells to monitor tissue or blood concentration levels of chemicals. The implanted cells produce a detectable electrical, optical or chemical signal in response to changes in concentration in surrounding medium. The signal is then detected and interpreted to give a reading indicative of blood concentration levels. Capsules containing chemo-sensitive cells and electrodes for detecting electrical activity are also disclosed. Methods of monitoring the concentration are also described utilizing the systems and capsules disclosed.
Inventors
- 👤 Yoram Palti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:42
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/48; A61B5/4836; A61B5/4839; A61B5/0002; A61B5/0015; A61B5/0017; A61B5/0031; A61B5/145; A61B5/14532
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
67 words
A system for monitoring the concentration of a chemical in a patient's blood, body or tissues, said system comprising: implantable living animal cells that are sensitive to said chemical, said animal cells being capable of producing an electrical, optical, or chemical signal in response to the chemical concentration in the medium surrounding said cells in the patient; and means for detecting said electrical, optical, or chemical signal.
Claim 2
Independent Claim
67 words
A system for monitoring the concentration of a chemical in a patient's blood, body or tissues, said system comprising: implantable living animal cells that are sensitive to said chemical, said animal cells being capable of producing an electrical, optical, or chemical signal in response to the chemical concentration in the medium surrounding said cells in the patient; and means for detecting said electrical, optical, or chemical signal.
Claim 3
Dependent Claim
28 words
The system of claim 1 wherein the animal cells are sensitive to the concentration of a chemical having a biological response in the patient's blood, body or tissues.
Claim 4
Dependent Claim
11 words
The system of claim 1 wherein said chemical is a hormone.
Claim 5
Dependent Claim
12 words
The system of claim 1 wherein said signal is an electrical signal.
Claim 6
Dependent Claim
39 words
The system of claim 4 wherein said cells are contained in a capsule and wherein the means for detecting said electrical, optical, or chemical signal comprises collecting means in said capsule for collecting said electrical signal from said cells.
Claim 7
Dependent Claim
31 words
The system of claim 5 wherein said collecting means are metal electrodes in contact with said cells such that said signal can be measured as a potential difference between said electrodes.
Claim 8
Dependent Claim
10 words
The system of claim 1 wherein said signal is optical.
Claim 9
Dependent Claim
18 words
The system of claim 7 wherein said signal results from changes in the optical characteristics of said cells.
Claim 10
Dependent Claim
33 words
The system of claim 8 wherein said optical characteristics are changed by dyes in or on the membranes of said cells that are affected by changes in the membrane potential of said membranes.
Claim 11
Dependent Claim
35 words
The system of claim 8 wherein the means for detecting said optical signal comprises an implantable optical sensing device positioned with respect to said cells so as to detect and process said signal for transmission.
Claim 12
Dependent Claim
33 words
The system of claim 10 wherein the means for detecting said optical signal further comprises transmission means connected to said implantable optical sensing device for transmitting said processed signal through a body surface.
Claim 13
Dependent Claim
37 words
The system of claim 1 wherein the means for detecting said electrical, optical or chemical signal comprises sensor means for detecting said signal through a patient's body surface and for correlating said signal to said chemical concentration.
Claim 14
Dependent Claim
44 words
The system of claim 12 wherein said sensor means comprises: detector means for detecting said signal; processor means connected to said detector means for correlating said signal to said chemical concentration; and output means connected to said processor means for reporting said chemical concentration.
Claim 15
Dependent Claim
24 words
The system of claim 1 wherein said cells are selected from the group consisting of beta cells, alpha cells, taste cells, and combinations thereof.
Claim 16
Dependent Claim
11 words
The system of claim 14 wherein said cells are beta cells.
Claim 17
Independent Claim
75 words
A method of monitoring the concentration of a chemical in a patient's blood, body or tissues, said method comprising: implanting into said patient chemical sensitive living animal cells which are sensitive to the concentration of said chemical and capable of producing an electrical, optical, or chemical signal in response to said concentration of said chemical in the medium surrounding said cells in the patient; detecting said signal; and correlating said signal with said chemical concentration.
Claim 18
Independent Claim
75 words
A method of monitoring the concentration of a chemical in a patient's blood, body or tissues, said method comprising: implanting into said patient chemical sensitive living animal cells which are sensitive to the concentration of said chemical and capable of producing an electrical, optical, or chemical signal in response to said concentration of said chemical in the medium surrounding said cells in the patient; detecting said signal; and correlating said signal with said chemical concentration.
Claim 19
Dependent Claim
28 words
The method of claim 16 wherein the animal cells are sensitive to the concentration of a chemical having a biological response in the patient's blood, body or tissue.
Claim 20
Dependent Claim
11 words
The method of claim 16 wherein said chemical is a hormone.
Claim 21
Dependent Claim
19 words
The method of claim 16 wherein said signal is detected through a body surface by an external signal sensor.
Claim 22
Dependent Claim
20 words
The method of claim 19 wherein said signal is processed by said sensor and correlated with said corresponding chemical concentration.
Claim 23
Dependent Claim
29 words
The method of claim 16 wherein the electrical or optical signal is detected by an implantable signal pickup device that processes said signal for transmission through a body surface.
Claim 24
Dependent Claim
20 words
The method of claim 21 wherein said processed signal is transmitted through said body surface and is sensed externally thereof.
Claim 25
Dependent Claim
16 words
The method of claim 22 wherein said transmitted signal is correlated with said corresponding chemical concentration.
Claim 26
Independent Claim
65 words
A method of administering a drug or chemical dosage, said method comprising: implanting into said patient chemical sensitive living animal cells capable of producing a signal in response to the concentration of a chemical in the medium surrounding said cells; detecting said signal; correlating said signal with said chemical concentration; and administering said drug or chemical dosage at a level appropriate to said chemical concentration.
Claim 27
Independent Claim
65 words
A method of administering a drug or chemical dosage, said method comprising: implanting into said patient chemical sensitive living animal cells capable of producing a signal in response to the concentration of a chemical in the medium surrounding said cells; detecting said signal; correlating said signal with said chemical concentration; and administering said drug or chemical dosage at a level appropriate to said chemical concentration.
Claim 28
Dependent Claim
11 words
The method of claim 24 wherein said chemical is a hormone.
Claim 29
Dependent Claim
17 words
The method of claim 24 wherein said dosage is administered by an implanted drug or chemical pump.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-11-28 | 1998-05-30 | 1998-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-11-28 | 2002-05-30 | 2002-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-11-28 | 2006-05-30 | 2006-11-29 | $7700.00 | Window Closed / Lapsed |