US5865167A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of living system organism diagnostics and apparatus for its realization
Assignee: GODIK EDUARD E (ALSO REFERENCED AS EDUARD A GODIK)
•
Filing: 1995-11-30
•
Granted: 1999-02-02
•
Expires: 2015-11-30
Abstract
Abstract A method of diagnostics of living organism state and an apparatus for its realization, comprising the steps of (i) illuminating living organism surface (1) with electromagnetic radiation from source (2) of optical wavelength range from 0.3 to 2.0μ, (ii) receiving transmitted through or back scattered by the living organism radiation by detectors (3 and 4), (iii) with the help of sequentially connected commutator (5), analog-to-digital converter (6) and input-output controller (7), spatial distribution of at least one parameter, characterizing transmittance and/or back scattering by living organism radiation in the computer system (8) is performed sequentially and continuously in time. At the above mentioned spatial distributions, spatial regions are revealed, differing from each other by at least one parameter, characterizing their temporal changes, and the revealed regions are recorded as a functional map of physiological processes taking place in living organism.
Inventors
- 👤 Eduard E. Godik
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 13:50
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/0059; A61B5/0073
Claims Analysis
Total Claims: 49
Claim 1
Independent Claim
260 words
An apparatus for diagnostics of a living organism, organ or tissue, comprising: a source of optical radiation of predetermined intensity providing a beam of said optical radiation having a wavelength range from 0.3 to 2.0 μm for illuminating a preselected portion of said living organism; means optically aligned with a portion of said living organism opposite said preselected portion for detecting the intensity of said radiation transmitted through said living organism and providing a signal representative thereof; means optically aligned adjacent said portion of said living organism for detecting the intensity of said radiation backscattered therefrom and providing a signal representative thereof; an interface system including: means operably connected to both of said detecting means for receiving said signals therefrom and providing sequential analog signals for processing, means operably connected to said means for receiving said signals from said detecting means for converting said analog signals to digital signals, an input/output controller operably connected to said converting means, said input/output controller including means for receiving said digital signals for transfer to a computer system and for receiving information from said computer system for transfer of said information back to both of said detecting means; and said computer system operably connected to said interface system, said computer system including means for receiving said digital signals, providing a temporal sequence of spatial maps, and converting said temporal sequence of spatial maps into at least one dynamic functional map representing spatial distribution of temporal changes to provide diagnostic information about functional conditions and synergy of physiological dynamics of said living organism under diagnosis.
Claim 2
Independent Claim
260 words
An apparatus for diagnostics of a living organism, organ or tissue, comprising: a source of optical radiation of predetermined intensity providing a beam of said optical radiation having a wavelength range from 0.3 to 2.0 μm for illuminating a preselected portion of said living organism; means optically aligned with a portion of said living organism opposite said preselected portion for detecting the intensity of said radiation transmitted through said living organism and providing a signal representative thereof; means optically aligned adjacent said portion of said living organism for detecting the intensity of said radiation backscattered therefrom and providing a signal representative thereof; an interface system including: means operably connected to both of said detecting means for receiving said signals therefrom and providing sequential analog signals for processing, means operably connected to said means for receiving said signals from said detecting means for converting said analog signals to digital signals, an input/output controller operably connected to said converting means, said input/output controller including means for receiving said digital signals for transfer to a computer system and for receiving information from said computer system for transfer of said information back to both of said detecting means; and said computer system operably connected to said interface system, said computer system including means for receiving said digital signals, providing a temporal sequence of spatial maps, and converting said temporal sequence of spatial maps into at least one dynamic functional map representing spatial distribution of temporal changes to provide diagnostic information about functional conditions and synergy of physiological dynamics of said living organism under diagnosis.
Claim 3
Independent Claim
32 words
The apparatus as defined in claims 1 further comprising means interconnected between said source and said interface system to substantially eliminate any temporal instability and inhomogeneities in the intensity of said source.
Claim 4
Dependent Claim
53 words
The apparatus as defined in claim 2 wherein said means interconnected between said source and said interface system to substantially eliminate any temporal instability and inhomogeneities in the intensity of said source comprises a beam splitter interposed between said source and said preselected portion of said living organism, a photodetector and an amplifier.
Claim 5
Dependent Claim
42 words
The apparatus as defined in claim 1 further comprising a sensor system operably interconnected to said source and said interface system, said sensor system including means adjacent said living organism for sensing at least one natural physiological rhythm of said living organism.
Claim 6
Dependent Claim
22 words
The apparatus as defined in claim 4 wherein one of said natural physiological rhythms of said living organism is its respiration rhythm.
Claim 7
Dependent Claim
22 words
The apparatus as defined in claim 4 wherein one of said natural physiological rhythms of said living organism is its cardiopulsation rhythm.
Claim 8
Dependent Claim
23 words
The apparatus as defined in claim 4 wherein one of said natural physiological rhythms of said living organism is its muscle tremor rhythm.
Claim 9
Dependent Claim
34 words
The apparatus as defined in claim 1 further comprising means for stroboscopically controlling said source to synchronize said beam output therefrom with a different one of said natural physiological rhythms of said living organism.
Claim 10
Dependent Claim
32 words
The apparatus as defined in claim 1 further comprising means interposed between said source and said living organism for focusing said beam to at least one preselected point on said preselected portion.
Claim 11
Dependent Claim
32 words
The apparatus as defined in claim 1 further comprising means interposed between said source and said living organism for scanning said beam to a preselected number of points on said preselected portion.
Claim 12
Dependent Claim
24 words
The apparatus as defined in claim 1 further comprising means interposed between said source and said portion for spectrally filtering said beam of radiation.
Claim 13
Dependent Claim
19 words
The apparatus as defined in claim 1 further comprising means connected to said source for frequency modulating said source.
Claim 14
Independent Claim
284 words
An apparatus for diagnostics of a living organism, comprising: a source of optical radiation of predetermined intensity providing a beam of said optical radiation having a preselected wavelength range for illuminating a preselected portion of said living organism; means optically aligned with a portion of said living organism opposite said preselected portion for detecting the intensity of said radiation transmitted through said living organism and providing a signal representative thereof; means optically aligned adjacent said portion of said living organism for detecting the intensity of said radiation backscattered therefrom and providing a signal representative thereof; an interface system including: means operably connected to both of said detecting means for receiving said signals therefrom and providing sequential analog signals for processing, means operably connected to said means for receiving said signals from said detecting means for converting said analog signals to digital signals, an input/output controller operably connected to said converting means, said input/output controller including means for receiving said digital signals for transfer to a computer system and receiving information from said computer system for transfer of said information back to both of said detecting means; a sensor system operably interconnected with said source and said interface system, said sensor system including means adjacent said living organism for sensing at least one natural physiological rhythm of said living organism; said computer system operably connected to said interface system, said computer system including means for receiving said digital signals, providing a temporal sequence of spatial maps, and converting said temporal sequence of spatial maps into at least one dynamic functional map representing spatial distribution of temporal changes to provide diagnostic information about functional conditions and synergy of physiological dynamics of said living organism under diagnosis.
Claim 15
Independent Claim
284 words
An apparatus for diagnostics of a living organism, comprising: a source of optical radiation of predetermined intensity providing a beam of said optical radiation having a preselected wavelength range for illuminating a preselected portion of said living organism; means optically aligned with a portion of said living organism opposite said preselected portion for detecting the intensity of said radiation transmitted through said living organism and providing a signal representative thereof; means optically aligned adjacent said portion of said living organism for detecting the intensity of said radiation backscattered therefrom and providing a signal representative thereof; an interface system including: means operably connected to both of said detecting means for receiving said signals therefrom and providing sequential analog signals for processing, means operably connected to said means for receiving said signals from said detecting means for converting said analog signals to digital signals, an input/output controller operably connected to said converting means, said input/output controller including means for receiving said digital signals for transfer to a computer system and receiving information from said computer system for transfer of said information back to both of said detecting means; a sensor system operably interconnected with said source and said interface system, said sensor system including means adjacent said living organism for sensing at least one natural physiological rhythm of said living organism; said computer system operably connected to said interface system, said computer system including means for receiving said digital signals, providing a temporal sequence of spatial maps, and converting said temporal sequence of spatial maps into at least one dynamic functional map representing spatial distribution of temporal changes to provide diagnostic information about functional conditions and synergy of physiological dynamics of said living organism under diagnosis.
Claim 16
Dependent Claim
34 words
The apparatus as defined in claim 13 further comprising means for stroboscopically controlling said source to synchronize said beam output therefrom with a different one of said natural physiological rhythms of said living organism.
Claim 17
Independent Claim
112 words
A method of diagnostics of a living organism, comprising the steps of: illuminating a preselected portion of said living organism with a beam of optical radiation having a wavelength range from 0.3 to 2.0 μm; detecting backscattered radiation from said preselected portion and detecting transmitted radiation through said living organism; continuously recording information obtained by detecting said backscattered and transmitted radiation; providing a temporal sequence of spatial maps based on said recorded information; and converting said temporal sequence of spatial maps into at least one dynamic functional map representing spatial distribution of temporal changes to provide diagnostic information about functional conditions and synergy of physiological dynamics of said living organism under diagnosis.
Claim 18
Independent Claim
112 words
A method of diagnostics of a living organism, comprising the steps of: illuminating a preselected portion of said living organism with a beam of optical radiation having a wavelength range from 0.3 to 2.0 μm; detecting backscattered radiation from said preselected portion and detecting transmitted radiation through said living organism; continuously recording information obtained by detecting said backscattered and transmitted radiation; providing a temporal sequence of spatial maps based on said recorded information; and converting said temporal sequence of spatial maps into at least one dynamic functional map representing spatial distribution of temporal changes to provide diagnostic information about functional conditions and synergy of physiological dynamics of said living organism under diagnosis.
Claim 19
Dependent Claim
30 words
The method as defined in claim 15 further comprising the step of selecting as said preselected portion of said living organism a skin area physiologically connected with an internal organ.
Claim 20
Dependent Claim
23 words
The method as defined in claim 16 further comprising the step of sensing at least one natural physiological rhythm of said living organism.
Claim 21
Dependent Claim
33 words
The method as defined in claim 17 further comprising the step of modulating by amplitude said beam of optical radiation synchronously with said at least one natural physiological rhythm of said living organism.
Claim 22
Dependent Claim
22 words
The method as defined in claim 17 wherein one of said natural physiological rhythms of said living organism is its respiration rhythm.
Claim 23
Dependent Claim
22 words
The method as defined in claim 17 wherein one of said natural physiological rhythms of said living organism is its cardiopulsation rhythm.
Claim 24
Dependent Claim
23 words
The method as defined in claim 17 wherein one of said natural physiological rhythms of said living organism is its muscle tremor rhythm.
Claim 25
Dependent Claim
22 words
The method as defined in claim 15 further comprising the step of modulating amplitude and/or frequency of said beam of optical radiation.
Claim 26
Dependent Claim
43 words
The method as defined in claim 15 further comprising the steps of concentrating said beam of radiation at a point on said portion of said living organism; and recording and analyzing temporal variations of radial distribution of said backscattered radiation around said beam.
Claim 27
Dependent Claim
18 words
The method as defined in claim 15 further comprising the step of spectral filtering said beam of radiation.
Claim 28
Dependent Claim
50 words
The method as defined in claim 15 further comprising the steps of: detecting spatial regions in sequentially recorded spatial distributions which are distinct from each other by at least one parameter; characterizing their temporal change; and recording and aggregating said spatial regions in the form of said dynamic functional map.
Claim 29
Dependent Claim
27 words
The method as defined in claim 25 further comprising the step of using as a distinctive parameter the cross correlation coefficient of said at least one parameter.
Claim 30
Dependent Claim
29 words
The method as defined in claim 25 further comprising the step of using as a distinctive parameter the velocity of temporal wave-like changes of said at least one parameter.
Claim 31
Dependent Claim
29 words
The method as defined in claim 25 further comprising the step of using as a distinctive parameter a frequency of temporal wave-like changes of said at least one parameter.
Claim 32
Dependent Claim
28 words
The method as defined in claim 25 further comprising the step of using as a distinctive parameter a temporal delay of changes of said at least one parameter.
Claim 33
Dependent Claim
33 words
The method as defined in claim 25 further comprising the step of using as a distinctive parameter a the number and position of extrema at temporal dynamics of said at least one parameter.
Claim 34
Dependent Claim
24 words
The method as defined in claim 25 wherein said recording step occurs synchronously with at least one natural physiological rhythm of said living organism.
Claim 35
Dependent Claim
22 words
The method as defined in claim 31 wherein one of said natural physiological rhythms of said living organism is its respiration rhythm.
Claim 36
Dependent Claim
22 words
The method as defined in claim 31 wherein one of said natural physiological rhythms of said living organism is its cardiopulsation rhythm.
Claim 37
Dependent Claim
23 words
The method as defined in claim 31 wherein one of said natural physiological rhythms of said living organism is its muscle tremor rhythm.
Claim 38
Dependent Claim
22 words
The method as defined in claim 15 further comprising the step of applying at least one external condition to said living organism.
Claim 39
Dependent Claim
13 words
The method as defined in claim 35 wherein vibration constitutes said external condition.
Claim 40
Dependent Claim
18 words
The method as defined in claim 36 further comprising the step of varying the frequency of said vibration.
Claim 41
Dependent Claim
15 words
The method as defined in claim 36 wherein an electric field constitutes said external condition.
Claim 42
Dependent Claim
15 words
The method as defined in claim 36 wherein a magnetic field constitutes said external condition.
Claim 43
Dependent Claim
23 words
The method of as defined in claim 39 further comprising the step of concentrating said magnetic field in an internal organ under diagnosis.
Claim 44
Dependent Claim
14 words
The method as defined in claim 35 wherein physical exercise constitutes said external condition.
Claim 45
Dependent Claim
13 words
The method as defined in claim 35 wherein ultrasound constitutes said external condition.
Claim 46
Dependent Claim
24 words
The method as defined in claim 42 further comprising the step of scanning an internal organ or deep tissue under diagnosis by said ultrasound.
Claim 47
Dependent Claim
13 words
The method as defined in claim 35 wherein pressure constitutes said external condition.
Claim 48
Dependent Claim
31 words
The method as defined in claim 44 further comprising the step of applying and/or removing said pressure for substantially less time than the time of physiological reaction of said living organism.
Claim 49
Dependent Claim
26 words
The method as defined in claim 45 further comprising the step of varying the time intervals between sequences of said applying and/or removing of said pressure.
References Cited (Backward Citations)
US3897150A
Cited
US3878392A
Cited
US4207901A
Cited
US4312357A
Cited
US4281645A
Cited
US4817038A
Cited
WO1979000594A1
Cited
US4212306A
Cited
US4286602A
Cited
US4515165A
Cited
US4385634A
Cited
US4583869A
Cited
US4573472A
Cited
US4434799A
Cited
US4576173A
Cited
US4495949A
Cited
US4536790A
Cited
US4570638A
Cited
US5139025A
Cited
US4829184A
Cited
US4948974A
Cited
US4649275A
Cited
US4767928A
Cited
US4807637A
Cited
US4774961A
Cited
US4798209A
Cited
US4817622A
Cited
US4810875A
Cited
US4862894A
Cited
US4927244A
Cited
US4955383A
Cited
US4945239A
Cited
US5079698A
Cited
US5269325A
Cited
US5222495A
Cited
US5170119A
Cited
US4995398A
Cited
US5197470A
Cited
US5099848A
Cited
US5213105A
Cited
US5303026A
Cited
US5307807A
Cited
US5333610A
Cited
US5293873A
Cited
US5309907A
Cited
US5301681A
Cited
US5337745A
Cited
US5305748A
Cited
US5371368A
Cited
US5313941A
Cited
US5515847A
Cited
US5311018A
Cited
US5572996A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-02-01 | 2002-08-03 | 2003-02-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-02-01 | 2006-08-03 | 2007-02-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-02-01 | 2010-08-03 | 2011-02-02 | $7700.00 | Window Closed / Lapsed |