US6458162B1
Expired / Lapsed
US
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Composite shaped bodies and methods for their production and use
Assignee: Orthovita Inc
•
Filing: 1999-08-13
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Granted: 2002-10-01
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Expires: 2019-08-13
Abstract
Abstract Shaped, composite bodies are provided. One portion of the shaped bodies comprises an RPR-derived porous inorganic material, preferably a calcium phosphate. Another portion of the composite bodies is a different solid material, preferably metal, glass, ceramic or polymeric. The shaped bodies are especially suitable for orthopaedic and other surgical use.
Inventors
- 👤 Antony Koblish
- 👤 Ronald S. Sapieszko
- 👤 David H. Dychala
- 👤 Eric M. Erbe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:03
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/28; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/84; A61B17/86; A61B17/866; A61F2/2875; A61F2/30; A61F2/32; A61F2/38; A61F2/3872; A61F2/44; A61F2/4455; A61L; A61L27/00; A61L27/02; A61L27/12; A61L27/40; A61L27/42; A61L27/425; A61L27/50; A61L27/56; A61B17/60; A61B17/64; A61B17/70; A61B17/74; A61B17/742; A61B17/80; A61C; A61C8/00; A61C8/0012; A61F2/2803; A61F2/3094; A61F2/3877; A61F2/389; A61F2/446; A61F2/4465; A61F2/447; A61F2002/2825; A61F2002/2882; A61F2002/30001; A61F2002/30108; A61F2002/3011; A61F2002/30182; A61F2002/30187; A61F2002/3895; A61F2002/448; A61F2230/00; A61F2230/0002; A61F2230/0028; A61F2230/0034; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2991; Y10T428/2993
Claims Analysis
Total Claims: 47
Claim 1
Independent Claim
62 words
A shaped body comprising a first solid portion and a second portion on the first solid portion comprising the oxidation-reduction reaction product of a blend comprising at least one metal cation; at least one oxidizing agent; and at least one precursor anion oxidizable by said oxidizing agent to form an oxoanion; said reaction having given rise to at least one gaseous product.
Claim 2
Dependent Claim
62 words
A shaped body comprising a first solid portion and a second portion on the first solid portion comprising the oxidation-reduction reaction product of a blend comprising at least one metal cation; at least one oxidizing agent; and at least one precursor anion oxidizable by said oxidizing agent to form an oxoanion; said reaction having given rise to at least one gaseous product.
Claim 3
Dependent Claim
12 words
The shaped body of claim 1 wherein said oxidizing agent is nitrate.
Claim 4
Dependent Claim
14 words
The shaped body of claim 1 wherein said gaseous product is a nitrogen oxide.
Claim 5
Dependent Claim
19 words
The shaped body of claim 1 wherein said reaction has been conducted at temperatures up to about 250° C.
Claim 6
Dependent Claim
19 words
The shaped body of claim 1 wherein said reaction has been conducted at temperatures up to about 800° C.
Claim 7
Dependent Claim
19 words
The shaped body of claim 1 wherein said reaction has been conducted at temperatures up to about 1400° C.
Claim 8
Dependent Claim
22 words
The shaped body of claim 1 wherein said reaction has been conducted at temperatures below the melting temperature of said reaction product.
Claim 9
Dependent Claim
14 words
The shaped body of claim 1 wherein said reaction product is a calcium phosphate.
Claim 10
Dependent Claim
12 words
The shaped body of claim 1 wherein said blend comprises an alcohol.
Claim 11
Dependent Claim
16 words
The shaped body of claim 1 wherein said metal cation forms part of the oxidizing agent.
Claim 12
Dependent Claim
17 words
The shaped body of claim 1 wherein said oxidizing agent and metal cation comprise a metal nitrate.
Claim 13
Dependent Claim
24 words
The shaped body of claim 1 wherein said metal cation is at least one of Li, Na, K, Rb, Cs, Cu, Ag or Hg.
Claim 14
Dependent Claim
31 words
The shaped body of claim 1 wherein said metal cation is at least one of divalent Be, Cr, Mn, Fe, Co, Ni, Cu, Zn, Rh, Pd, Cd, Sn, Hr or Pb.
Claim 15
Dependent Claim
50 words
The shaped body of claim 1 wherein said metal cation is at least one of tri- or tetravalent Al, Cr, Mn, Fe, Co, Ni, Ga, As, Y, Nb, Rh, In, La, Tl, Bi, Ac, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, U, or Pu.
Claim 16
Dependent Claim
13 words
The shaped body of claim 1 , wherein said metal cation comprises Ca.
Claim 17
Dependent Claim
10 words
The shaped body of claim 1 having a preselected shape.
Claim 18
Dependent Claim
18 words
The shaped body of claim 2 wherein said preselected shape mimics a bony structure on the human body.
Claim 19
Dependent Claim
17 words
The shaped body of claim 2 wherein said preselected shape is adapted to fit a bone excavation.
Claim 20
Dependent Claim
44 words
The shaped body of claim 1 wherein said preselected shape is in the form of a rod, screw, pin, dowel, vertebra, vertebral segment, intervertebral disk, intervertebral disk segment or spacer, orthopaedic cage, orthopaedic block, vertebral ring, interbody fusion device, tri-cortical device, crouton, or splint.
Claim 21
Dependent Claim
18 words
The shaped body of claim 1 having a plurality of orifices in at least one exterior surface thereof.
Claim 22
Dependent Claim
14 words
The shaped body of claim 1 wherein said first solid portion comprises a polymer.
Claim 23
Dependent Claim
21 words
The shaped body of claim 21 wherein said polymer is formed from a polymerized matrix and at least one inorganic filler.
Claim 24
Dependent Claim
15 words
The shaped body of claim 22 wherein said polymer comprises at least one acrylic species.
Claim 25
Dependent Claim
16 words
The shaped body of claim 22 wherein said polymer further comprises at least one organic filler.
Claim 26
Dependent Claim
17 words
The shaped body of claim 24 wherein said organic filler comprises fibers, a web or particulate material.
Claim 27
Dependent Claim
12 words
The shaped body of claim 22 wherein said inorganic filler comprises combeite.
Claim 28
Dependent Claim
26 words
The shaped body of claim 26 wherein said combeite is present in an amount of at least about 2 percent by weight of the inorganic filler.
Claim 29
Dependent Claim
16 words
The shaped body of claim 26 wherein said combeite is in the form of heterogeneous particles.
Claim 30
Dependent Claim
17 words
The shaped body of claim 26 wherein said particles have particle sizes greater than about 0.1 micron.
Claim 31
Dependent Claim
24 words
The shaped body of claim 29 wherein at least 95 percent by weight of said particles have particle sizes between 0.2 and 100 microns.
Claim 32
Dependent Claim
39 words
The shaped body of claim 26 wherein said inorganic filler further comprises at least one of hydroxyapatite, fluorapatite, oxyapatite, Wollastonite, anorthite, calcium fluoride, agrellite, devitrite, canasite, phlogopite, monotite, brushite, octocalcium phosphate, Whitlockite, tetracalcium phosphate, cordierite, Berlinite or mixtures thereof.
Claim 33
Dependent Claim
13 words
The shaped body of claim 21 wherein said polymer comprises a bisphenol-A dimethacrylate.
Claim 34
Dependent Claim
13 words
The shaped body of claim 32 wherein said dimethacrylate is a diglycidyl methacrylate.
Claim 35
Dependent Claim
21 words
The shaped body of claim 21 wherein said polymer has been hardened through the activity of a heat or actinic light.
Claim 36
Dependent Claim
12 words
The shaped body of claim 1 wherein said second portion is spongiform.
Claim 37
Dependent Claim
13 words
The shaped body of claim 1 in combination with a hardenable fluid material.
Claim 38
Dependent Claim
17 words
The shaped body of claim 36 wherein said fluid material is a liquid, paste, putty or gel.
Claim 39
Dependent Claim
12 words
The shaped body of claim 36 wherein said fluid material is polymerizable.
Claim 40
Dependent Claim
12 words
The shaped body of claim 36 wherein said fluid material is acrylic.
Claim 41
Dependent Claim
13 words
The shaped body of claim 36 further comprising a plurality of orifices therein.
Claim 42
Dependent Claim
71 words
A restorative system comprising a shaped body comprising a first solid portion and a second portion on the first solid portion comprising the oxidation-reduction reaction product of a blend comprising at least one metal cation; at least one oxidizing agent; and at least one precursor anion oxidizable by said oxidizing agent to form an oxoanion; said reaction having given rise to at least one gaseous product; and a hardenable fluid material.
Claim 43
Dependent Claim
71 words
A restorative system comprising a shaped body comprising a first solid portion and a second portion on the first solid portion comprising the oxidation-reduction reaction product of a blend comprising at least one metal cation; at least one oxidizing agent; and at least one precursor anion oxidizable by said oxidizing agent to form an oxoanion; said reaction having given rise to at least one gaseous product; and a hardenable fluid material.
Claim 44
Dependent Claim
17 words
The restorative system of claim 41 wherein said fluid material is a liquid, paste, putty or gel.
Claim 45
Dependent Claim
12 words
The restorative system of claim 41 wherein said fluid material is polymerizable.
Claim 46
Dependent Claim
12 words
The restorative system of claim 41 wherein said fluid material is acrylic.
Claim 47
Dependent Claim
29 words
The restorative system of claim 41 further comprising a plurality of orifices therein for placement of the fluid material adjacent to the shaped body within a prepared osseous cavity.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-09-30 | 2006-04-01 | 2006-10-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-09-30 | 2010-04-01 | 2010-10-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-09-30 | 2014-04-01 | 2014-10-01 | $7700.00 | Window Closed / Lapsed |