US5129905A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for in situ prepared calcium phosphate minerals
Assignee: Norian Corp
•
Filing: 1989-08-14
•
Granted: 1992-07-14
•
Expires: 2009-08-14
Abstract
Abstract Calcium phosphate minerals are formed by using phosphoric acid source substantially free of uncombined water in conjunction with a calcium source, normally as any combination of carbonate, phosphate and hydroxide, and, as required, any additional base to neutralize the phosphoric acid. Protein may be optionally added. The resulting product is readily formed and then sets to a hard, stable, workable shaped object.
Inventors
- 👤 Brent R. Constantz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:29
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/02; A61K; A61K6/00; A61K6/30; A61K6/50; A61K6/54; A61K6/80; A61K6/831; A61K6/838; A61L27/00; A61L27/02; A61L27/12; A61L27/40; A61L27/44; A61L27/46; C; C01; C01B; C01B25/00; C01B25/16; C01B25/26; C01B25/32; C01B25/322; C01B25/327; C01B25/455; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
106 words
A method for making calcium phosphate minerals comprising: combining a partially neutralized phosphoric acid source substantially free of uncombined water, wherein said partial neutralization is not more than about neutralization of the first proton of phosphoric acid, which is then combined with a calcium source, and neutralizing anions including at least one of carbonate, phosphate and hydroxide in an amount sufficient to substantially neutralise said phosphoric acid source, and a physiologically acceptable lubricant in an amount to provide a kneadable mixture; agitating the mixture to produce a substantially uniform mixture; and allowing the substantially uniform mixture to set and become annealed to a hard workable structure.
Claim 2
Independent Claim
106 words
A method for making calcium phosphate minerals comprising: combining a partially neutralized phosphoric acid source substantially free of uncombined water, wherein said partial neutralization is not more than about neutralization of the first proton of phosphoric acid, which is then combined with a calcium source, and neutralizing anions including at least one of carbonate, phosphate and hydroxide in an amount sufficient to substantially neutralise said phosphoric acid source, and a physiologically acceptable lubricant in an amount to provide a kneadable mixture; agitating the mixture to produce a substantially uniform mixture; and allowing the substantially uniform mixture to set and become annealed to a hard workable structure.
Claim 3
Dependent Claim
16 words
A method according to claim 1, wherein calcium phosphate crystals are combined in said combining step.
Claim 4
Dependent Claim
19 words
A method according to claim 1, wherein said phosphoric acid source is calcium phosphate monobasic or the monohydrate thereof.
Claim 5
Dependent Claim
38 words
A method according to claim 3, wherein said phosphoric acid source and calcium source are premixed prior to combining with the water or the calcium source and water are precombined prior to combining with said phosphoric acid source.
Claim 6
Dependent Claim
19 words
A method according to claim 1, wherein said calcium source is present at least in part as calcium carbonate.
Claim 7
Dependent Claim
15 words
A method according to claim 1, wherein a protein is combined in said combining step.
Claim 8
Dependent Claim
38 words
A method according to claim 1 wherein said calcium phosphate mineral is hydroxyapatite and a source of fluoride or chloride is included in the mixture formed to displace at least 10% of the hydroxy groups of said hydroxyapatite.
Claim 9
Independent Claim
78 words
A method for making hydroxyapatite comprising: combining calcium phosphate monobasic or its monohydrate, a neutralizing source comprising at least one of calcium carbonate, alkali metal hydroxide, calcium hydroxide or a calcium phosphate, in an amount to provide a substantially neutral product, and an aqueous lubricant in an amount to provide a kneadable mixture; agitating the mixture to produce a substantially uniform mixture; and allowing the substantially uniform mixture to set and become matured to a hard workable structure.
Claim 10
Independent Claim
78 words
A method for making hydroxyapatite comprising: combining calcium phosphate monobasic or its monohydrate, a neutralizing source comprising at least one of calcium carbonate, alkali metal hydroxide, calcium hydroxide or a calcium phosphate, in an amount to provide a substantially neutral product, and an aqueous lubricant in an amount to provide a kneadable mixture; agitating the mixture to produce a substantially uniform mixture; and allowing the substantially uniform mixture to set and become matured to a hard workable structure.
Claim 11
Dependent Claim
23 words
A method according to claim 8, wherein said calcium phosphate monobasic or its monohydrate and neutralizing source are precombined in a uniform mixture.
Claim 12
Dependent Claim
35 words
A method according to claim 8, wherein said calcium phosphate monobasic or its monohydrate is present in 2-12 parts by weight, and a calcium neutralizing source is present in from about 6-15 parts by weight.
Claim 13
Dependent Claim
23 words
A method according to claim 9, wherein said calcium neutralizing source is at least one of calcium tetraphosphate, calcium hydroxide or calcium carbonate.
Claim 14
Dependent Claim
14 words
A method according to claim 8, wherein said maturing occurs in situ in bone.
Claim 15
Dependent Claim
29 words
A method according to claim 8, wherein a source of fluoride or chloride is included in said mixture to displace at least 10% of the hydroxyl groups of hydroxyapatite.
Claim 16
Dependent Claim
36 words
A method according to claim 13, wherein CaSiF 6 , Na 2 SiF 6 , NaF or CaCl 2 is included in said mixture to displace at least 10% of the hydroxyl groups of said hydroxyapatite.
Claim 17
Dependent Claim
17 words
A method according to claim 8, wherein 0.2-2 parts of collagen is combined in said combining step.
Claim 18
Dependent Claim
45 words
A method according to claim 8, wherein dilute HF or HCl of less than about 1M are included with a carbonate anion calcium source, wherein said HF or HCl are in sufficient amount to displace at least 10% of the hydroxyl groups of said hydroxyapatite.
References Cited (Backward Citations)
GB917328A
Cited
FR2096886A1
Cited
US4157378A
Cited
AU4323479A
Cited
GB1487181A
Cited
DE2755751A1
Cited
JPS53111000A
Cited
EP0026090A2
Cited
US4429691A
Cited
US4497075A
Cited
US4487749A
Cited
FR2537558A1
Cited
SU1331501A1
Cited
JPS60143762A
Cited
JPS62132713A
Cited
JPS63252913A
Cited
US4880610A
Cited
US4849193A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-07-14 | 1996-01-13 | 1996-07-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-14 | 2000-01-13 | 2000-07-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-14 | 2004-01-13 | 2004-07-14 | $7700.00 | Window Closed / Lapsed |