US6375680B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substrates for forming synthetic tissues
Assignee: St Jude Medical LLC
•
Filing: 1998-12-01
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Granted: 2002-04-23
•
Expires: 2018-12-01
Abstract
Abstract A prosthesis is formed from a substrate with an associated attraction compound. The attraction compound binds viable precursor cells to the substrate. Thus, the substrate forms a synthetic tissue supporting viable cells once the substrate is contacted with a solution containing viable precursor cells. Preferred precursor cells differentiate into fibroblasts or into endothelial cells.
Inventors
- 👤 Wenda C. Carlyle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:34
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/28; A61L27/34
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
30 words
A prosthesis comprising a substrate with an associated attraction compound, the attraction compound binding viable fibroblast precursor cells with the substrate, wherein the attraction compound is not a growth factor.
Claim 2
Dependent Claim
30 words
A prosthesis comprising a substrate with an associated attraction compound, the attraction compound binding viable fibroblast precursor cells with the substrate, wherein the attraction compound is not a growth factor.
Claim 3
Dependent Claim
13 words
The prosthesis of claim 1 wherein the prosthesis is a heart valve prosthesis.
Claim 4
Dependent Claim
12 words
The prosthesis of claim 1 wherein the prosthesis is a vascular prosthesis.
Claim 5
Dependent Claim
11 words
The prosthesis of claim 1 wherein the substrate comprises a tissue.
Claim 6
Dependent Claim
11 words
The prosthesis of claim 1 wherein the substrate comprises uncrosslinked tissue.
Claim 7
Dependent Claim
12 words
The prosthesis of claim 1 wherein the substrate comprises a bioresorbable polymer.
Claim 8
Dependent Claim
11 words
The prosthesis of claim 1 wherein the substrate comprises a fabric.
Claim 9
Dependent Claim
11 words
The prosthesis of claim 7 wherein the fabric comprises synthetic polymers.
Claim 10
Dependent Claim
11 words
The prosthesis of claim 1 wherein the attraction compound comprises antibodies.
Claim 11
Dependent Claim
17 words
The prosthesis of claim 9 wherein the antibodies exhibit some specificity for precursor cells expressing HLA-DR specificity.
Claim 12
Dependent Claim
38 words
A method for distributing a medical article for use by health care professionals, the method comprising placing a prosthesis of claim 1 into a package under sterile conditions and distributing the package for use by health care professionals.
Claim 13
Dependent Claim
19 words
The prosthesis of claim 1 wherein a growth factor, distinct from the attraction compound, is associated with the substrate.
Claim 14
Independent Claim
38 words
A method of producing a prosthesis, the method comprising forming the prosthesis at least partially from a substrate with an associated attraction compound that attracts viable fibroblast precursor cells, wherein the attraction compound is not a growth factor.
Claim 15
Independent Claim
38 words
A method of producing a prosthesis, the method comprising forming the prosthesis at least partially from a substrate with an associated attraction compound that attracts viable fibroblast precursor cells, wherein the attraction compound is not a growth factor.
Claim 16
Dependent Claim
19 words
The method of claim 13 wherein the prosthesis is a heart valve prosthesis and wherein the substrate comprises tissue.
Claim 17
Dependent Claim
17 words
The method of claim 13 wherein the attraction compound is associated with the substrate by chemical binding.
Claim 18
Dependent Claim
16 words
The method of claim 15 wherein the attraction compound is associated with the substrate by crosslinking.
Claim 19
Dependent Claim
18 words
The method of claim 15 wherein the attraction compound is associated with the substrate with specific binding interactions.
Claim 20
Dependent Claim
17 words
The method of claim 13 wherein the attraction compound is associated with the substrate by direct attachment.
Claim 21
Dependent Claim
17 words
The method of claim 13 wherein the attraction compound is associated with the substrate with an adhesive.
Claim 22
Dependent Claim
28 words
A prosthesis comprising a substrate with an associated attraction compound, the attraction compound binding viable endothelial cell precursor cells, wherein the attraction compound is not a growth factor.
Claim 23
Dependent Claim
28 words
A prosthesis comprising a substrate with an associated attraction compound, the attraction compound binding viable endothelial cell precursor cells, wherein the attraction compound is not a growth factor.
Claim 24
Dependent Claim
36 words
The prosthesis of claim 20 wherein the attraction compounds are selected from the group consisting of antibodies, antibody fragments, humanized antibodies, ligands for CD 34 antigen, ligands for endoglin, ligands for ε-selectin, and ligands for CD31.
Claim 25
Dependent Claim
19 words
The prosthesis of claim 20 wherein the attraction compound has an affinity constant less than about 10 −10 moles/liter.
Claim 26
Dependent Claim
17 words
The prosthesis of claim 20 wherein the attraction compounds comprise a ligand for angioblast cell surface receptors.
Claim 27
Dependent Claim
13 words
The prosthesis of claim 20 wherein the prosthesis is a heart valve prosthesis.
Claim 28
Dependent Claim
11 words
The prosthesis of claim 20 wherein the substrate comprises uncrosslinked tissue.
Claim 29
Dependent Claim
11 words
The prosthesis of claim 20 wherein the substrate comprises crosslinked tissue.
Claim 30
Dependent Claim
11 words
The prosthesis of claim 20 wherein the substrate comprises a fabric.
Claim 31
Dependent Claim
19 words
The prosthesis of claim 20 wherein a growth factor, distinct from the attraction compound, is associated with the substrate.
Claim 32
Dependent Claim
36 words
A prosthesis comprising a substrate with an associated attraction compound and an associated response modifier distinct from the attraction compound, the attraction compound binding viable fibroblast precursor cells or viable endothelial precursor cells with the substrate.
Claim 33
Dependent Claim
36 words
A prosthesis comprising a substrate with an associated attraction compound and an associated response modifier distinct from the attraction compound, the attraction compound binding viable fibroblast precursor cells or viable endothelial precursor cells with the substrate.
Claim 34
Dependent Claim
17 words
The prosthesis of claim 29 wherein the attraction compound binds viable fibroblast precursor cells with the substrate.
Claim 35
Dependent Claim
16 words
The prosthesis of claim 29 wherein the attraction compound binds viable endothelial cells with the substrate.
Claim 36
Dependent Claim
15 words
The prosthesis of claim 29 wherein the response modifier comprises compounds that promote cell differentiation.
Claim 37
Dependent Claim
16 words
The prosthesis of claim 29 wherein the response modifier comprises compounds that inhibit an inflammatory response.
Claim 38
Dependent Claim
13 words
The prosthesis of claim 29 wherein the prosthesis is a heart valve prosthesis.
Claim 39
Dependent Claim
10 words
The prosthesis of claim 29 wherein the substrate comprises tissue.
Claim 40
Dependent Claim
11 words
The prosthesis of claim 29 wherein the substrate comprises synthetic polymers.
Claim 41
Dependent Claim
11 words
The prosthesis of claim 29 wherein the attraction compound comprises antibodies.
Claim 42
Dependent Claim
12 words
The prosthesis of claim 29 wherein the attraction compound comprises a ligand.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2005-04-22 | 2005-10-22 | 2006-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-04-22 | 2009-10-22 | 2010-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-04-22 | 2013-10-22 | 2014-04-23 | $7700.00 | Window Closed / Lapsed |