US6110212A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Elastin and elastin-based materials
Assignee: Biomedical Research Services Inc
•
Filing: 1997-02-07
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Granted: 2000-08-29
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Expires: 2017-02-07
Abstract
Abstract It is a general object of the invention to provide a method of effecting repair or replacement or supporting a section of a body tissue. Specifically to provide an elastin or elastin-based biomaterial suitable for use as a stent, for example, a vascular stent, or as conduit replacement, as an artery, vein or a ureter replacement. The biomaterial can also be used as a stent or conduit covering or coating or lining. It is also an object of the invention to provide a method of securing an elastin or elastin-based biomaterial to an existing tissue without the use of sutures or staples.
Inventors
- 👤 Kenton W. Gregory
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 07:25
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/0063; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/36; A61L27/3641; A61L27/3683; A61L27/3691; A61L27/38; A61L27/3804; A61L27/3839; A61L27/50; A61L31/00; A61L31/005; A61L31/04; A61L31/043; A61L31/047; A61L31/14; B; B32; B32B; B32B5/00; B32B5/02; B32B9/00; B32B9/02; A61F2/042; A61F2/82; A61F2/86; A61F2/90; A61F2/91; A61F2002/072; A61F2002/075; Y; Y10; Y10S; Y10S623/00; Y10S623/915
Claims Analysis
Total Claims: 75
Claim 1
Independent Claim
155 words
A method for producing a biomaterial consisting essentially of elastin capable of being fused onto a tissue substrate comprising: forming a layer of biomaterial consisting essentially of elastin having a first and second outer major surface; and applying an energy absorbing material, which is energy absorptive within a predetermined range of light wavelengths, to a selected one of said first and second outer surfaces of the biomaterial in an amount which will cause using together of one of said first and second outer surfaces of the biomaterial and an outer surface of said tissue substrate, said energy absorbing material penetrating into an interstices of said biomaterial, the selected one of said first and second outer surfaces of the biomaterial being capable of fusing together with the outer surface of the tissue substrate by irradiating the energy absorbing material with light energy in a predetermined wavelength range with an intensity sufficient to facilitate said fusing together.
Claim 2
Independent Claim
155 words
A method for producing a biomaterial consisting essentially of elastin capable of being fused onto a tissue substrate comprising: forming a layer of biomaterial consisting essentially of elastin having a first and second outer major surface; and applying an energy absorbing material, which is energy absorptive within a predetermined range of light wavelengths, to a selected one of said first and second outer surfaces of the biomaterial in an amount which will cause using together of one of said first and second outer surfaces of the biomaterial and an outer surface of said tissue substrate, said energy absorbing material penetrating into an interstices of said biomaterial, the selected one of said first and second outer surfaces of the biomaterial being capable of fusing together with the outer surface of the tissue substrate by irradiating the energy absorbing material with light energy in a predetermined wavelength range with an intensity sufficient to facilitate said fusing together.
Claim 3
Dependent Claim
43 words
The method of claim 1, wherein the step of irradiating the energy absorbing material comprises indirectly irradiating said energy absorbing material by directing light energy first through either one of the biomaterial and the tissue substrate, and then to the energy absorbing material.
Claim 4
Dependent Claim
13 words
The method of claim 1, wherein said energy absorbing material comprises a chromophore.
Claim 5
Dependent Claim
15 words
The method of claim 1, wherein said energy absorbing material comprises an energy absorbing dye.
Claim 6
Dependent Claim
27 words
The method of claim 1, which further includes the step of substantially dissipating said energy absorbing material when said biomaterial and said tissue substrate are fused together.
Claim 7
Dependent Claim
28 words
The method of claim 1, which further includes the step of staining either one of the first and second surface of said biomaterial with said energy absorbing material.
Claim 8
Dependent Claim
47 words
The method of claim 1, which further includes the step of applying said energy absorbing material to one of said outer surfaces of said biomaterial by doping a separate elastin layer with an energy absorbing material, and then fusing the doped separate elastin layer to the biomaterial.
Claim 9
Dependent Claim
28 words
The method of claim 1, wherein the energy absorbing layer is substantially uniformly applied to a selected one of said first and second outer surfaces of the biomaterial.
Claim 10
Dependent Claim
25 words
The method of claim 1, which further includes the step of covering substantially the entire outer surface of the biomaterial with the energy absorbing material.
Claim 11
Dependent Claim
60 words
The method of claim 1, which further includes the step of irradiating the energy absorbing material with light energy at a localized temperature of from about 40 to 600 degrees C. for period of time sufficient to cause fusing together of one of said first and second outer surfaces of the biomaterial and an outer surface of said tissue substrate.
Claim 12
Dependent Claim
64 words
The method of claim 1, which further includes the step of irradiating the energy absorbing material with light energy resulting in a localized temperature at an interface of said biomaterial and said tissue substrate being from about 50 to 100 degrees C. for a sufficient duration to fuse together one of said first and second outer surfaces of the biomaterial and said tissue substrate.
Claim 13
Dependent Claim
29 words
The method of claim 1, wherein the average thickness of the energy absorbing material which penetrates into the interstices of the biomaterial is from about 0.5 to 300 microns.
Claim 14
Dependent Claim
82 words
The method of claim 1, which further includes the step of arranging the magnitude of the wave length, energy level, absorption, and light intensity during irradiation with light energy of the energy absorbing material, and the concentration of the energy absorbing material, so that the localized temperature at the interface of said first and second outer surfaces of the biomaterial and the tissue substrate are maintained at from about 40 to 140° C., thereby fusing together the biomaterial and the tissue substrate.
Claim 15
Dependent Claim
14 words
The method of claim 1, wherein the tissue substrate is a human tissue substrate.
Claim 16
Dependent Claim
47 words
The method of claim 1, which further includes a step of employing said biomaterial for either one of replacement and repair of human tissue selected from a group consisting of bladders, intestines, tubes, esophagus, ureters, arteries, veins, stomachs, lungs, hearts, colons, skin, or as a cosmetic implantation.
Claim 17
Dependent Claim
38 words
The method of claim 1, which further includes the step of forming said biomaterial into a tree-dimensional support structure wherein said elastin or elastin-based material is combined with a stromal support matrix populated with actively growing stromal cells.
Claim 18
Dependent Claim
12 words
The method of claim 16, wherein said stromal support matrix comprises fibroblasts.
Claim 19
Dependent Claim
24 words
The method of claim 1, which further includes forming a cellular lining of human cells on one of the major surfaces of said biomaterial.
Claim 20
Dependent Claim
31 words
The method of claim 18, wherein said human cells which are employed to form such a lining are selected from the group consisting of endothelial cells, epithelial cells and urothelial cells.
Claim 21
Dependent Claim
30 words
The method of claim 1, which further includes the step of forming a biomaterial inner lining for mechanical human structures to ensure their continued internal use in a human body.
Claim 22
Dependent Claim
25 words
The method of claim 20, wherein the inner lining is employed in heart valves, heart implants, dialysis equipment, or oxygenator tubing for heart-lung by-pass systems.
Claim 23
Dependent Claim
26 words
The method of claim 1, which includes the step of incorporating a drug into said biomaterial thereby decreasing the need for systemic intravenous or oral medications.
Claim 24
Independent Claim
156 words
A method for using an biomaterial consisting essentially of elastin in biomedical applications comprising: forming a layer of biomaterial consisting essentially of elastin having a first and second outer major surface; applying an energy absorbing material, which is energy absorptive within a predetermined range of light wavelengths, to a selected one of said first and second outer surfaces of the biomaterial, in an amount which will cause fusing together of one of said first and second outer surfaces of the biomaterial and an outer surface of a tissue substrate, said energy absorbing material penetrating into an interstices of said biomaterial, the selected one of said first and second outer surfaces of the biomaterial being capable of fusing together with the outer surface of the tissue substrate by irradiating the energy absorbing material with light energy in a predetermined wavelength range with an intensity sufficient to facilitate said fusing together; and using said biomaterial in biomedical applications.
Claim 25
Independent Claim
156 words
A method for using an biomaterial consisting essentially of elastin in biomedical applications comprising: forming a layer of biomaterial consisting essentially of elastin having a first and second outer major surface; applying an energy absorbing material, which is energy absorptive within a predetermined range of light wavelengths, to a selected one of said first and second outer surfaces of the biomaterial, in an amount which will cause fusing together of one of said first and second outer surfaces of the biomaterial and an outer surface of a tissue substrate, said energy absorbing material penetrating into an interstices of said biomaterial, the selected one of said first and second outer surfaces of the biomaterial being capable of fusing together with the outer surface of the tissue substrate by irradiating the energy absorbing material with light energy in a predetermined wavelength range with an intensity sufficient to facilitate said fusing together; and using said biomaterial in biomedical applications.
Claim 26
Dependent Claim
35 words
The method of claim 23, which further includes the step of forming said biomaterial into a three-dimensional support structure wherein said biomaterial is combined with a stromal support matrix populated with actively growing stromal cells.
Claim 27
Dependent Claim
12 words
The method of claim 24, wherein said stromal support matrix comprises fibroblasts.
Claim 28
Dependent Claim
28 words
The method of claim 23, which further includes the step of forming a cellular lining of human cells on one of the major surfaces of said biomaterial layer.
Claim 29
Dependent Claim
30 words
The method of claim 26, wherein said human cells which are employed to form a lining are selected from the group consisting of endothelial cells, epithelial cells and urothelial cells.
Claim 30
Independent Claim
34 words
The method of claims 23, which further includes the step of forming an inner lining of said biomaterial layer for for mechanical human structures to ensure their continued internal use in a human body.
Claim 31
Dependent Claim
26 words
The method of claim 23, which includes the step of incorporating a drug into said biomaterial thereby decreasing the need for systemic intravenous or oral medications.
Claim 32
Independent Claim
57 words
A method for using a biomaterial consisting essentially of elastin, which comprises: forming a biomaterial consisting essentially of an elastin having a first and second outer major surface, applying an energy absorbing material, which is energy absorptive within the second outer major surface; and using said biomaterial having said energy absorbing material applied thereon in biomedical applications.
Claim 33
Independent Claim
57 words
A method for using a biomaterial consisting essentially of elastin, which comprises: forming a biomaterial consisting essentially of an elastin having a first and second outer major surface, applying an energy absorbing material, which is energy absorptive within the second outer major surface; and using said biomaterial having said energy absorbing material applied thereon in biomedical applications.
Claim 34
Dependent Claim
15 words
The method of claim 30, wherein the biomaterial is applied to a human tissue substrate.
Claim 35
Dependent Claim
42 words
The method of claim 30, which further includes the step of employing the biomaterial elastin for replacement or repair of a human tissue selected from the group consisting of bladders, intestines, tubes, esophagus, ureters, arteries, veins, stomachs, lungs, hearts, colons, and skin.
Claim 36
Dependent Claim
35 words
The method of claim 30, which further includes the step of forming a biomaterial into a three-dimensional support structure wherein said biomaterial is combined with a stromal support matrix populated with actively growing stromal cells.
Claim 37
Dependent Claim
12 words
The method of claim 33, wherein said stromal support matrix comprise fibroblasts.
Claim 38
Dependent Claim
25 words
The method of claim 30, which further includes the step of forming a cellular lining of human cells on a major surface of said biomaterial.
Claim 39
Dependent Claim
31 words
The method of claim 35, wherein said human cells which are employed to form a lining are are selected from the group consisting of endothelial cells, epithelial cells and urothelial cells.
Claim 40
Dependent Claim
34 words
The method of claim 30, which further includes the step of forming a biomaterial inner lining of said biomaterial layer for mechanical human structures to ensure their continued internal use in a human body.
Claim 41
Dependent Claim
26 words
The method of claim 37, wherein the biomaterial inner lining is employed in heart valves, heart implants, dialysis equipment, or oxygenator tubing for heart-lung by-pass systems.
Claim 42
Dependent Claim
26 words
The method of claim 30, which includes the step of incorporating a drug into said biomaterial thereby decreasing the need for systemic intravenous or oral medications.
Claim 43
Independent Claim
37 words
A method for using a biomaterial consisting essentially of elastin, which comprises: forming a layer of biomaterial consisting essentially of elastin having a first and second outer major surface; and using said biomaterial layer in biomedical applications.
Claim 44
Independent Claim
37 words
A method for using a biomaterial consisting essentially of elastin, which comprises: forming a layer of biomaterial consisting essentially of elastin having a first and second outer major surface; and using said biomaterial layer in biomedical applications.
Claim 45
Dependent Claim
22 words
The method of claim 40, wherein one of said first and second outer major surfaces is fused to a human tissue substrate.
Claim 46
Dependent Claim
47 words
The method of claim 40, which further includes a step of employing said biomaterial for either one of replacement and repair of human tissue selected from a group consisting of bladders, intestines, tubes, esophagus, ureters, arteries, veins, stomachs, lungs, hearts, colons, skin, or as a cosmetic implantation.
Claim 47
Dependent Claim
35 words
The method of claim 40, which further includes the step of forming a biomaterial into a three-dimensional support structure wherein said biomaterial is combined with a stromal support matrix populated with actively growing stromal cells.
Claim 48
Dependent Claim
12 words
The method of claim 43, wherein said stromal support matrix comprise fibroblasts.
Claim 49
Dependent Claim
24 words
The method of claim 40, which further includes forming a cellular lining of human cells on one of the major surfaces of said biomaterial.
Claim 50
Dependent Claim
32 words
The method of claim 40, wherein said human cells which are employed to form such a lining are are selected from the group consisting of endothelial cells, epithelial cells and urothelial cells.
Claim 51
Dependent Claim
34 words
The method of claim 40, which further includes the step of forming a biomaterial inner lining of said biomaterial layer for mechanical human structures to ensure their continued internal use in a human body.
Claim 52
Dependent Claim
26 words
The method of claim 47, wherein the biomaterial inner lining is employed in heart valves, heart implants, dialysis equipment, or oxygenator tubing for heart-lung by-pass systems.
Claim 53
Dependent Claim
26 words
The method of claim 40, which includes the step of incorporating a drug into said biomaterial thereby decreasing the need for systemic intravenous or oral medications.
Claim 54
Dependent Claim
147 words
A biomaterial capable of being fused onto a tissue substrate comprising: a layer of biomaterial consisting essentially of elastin having a first and second outer major surface; and an energy absorbing material, which is energy absorptive within a predetermined range of light wavelengths, applied to a selected one of said first and second outer surfaces of the biomaterial in an amount which will cause fusing together of one of said first and second outer surfaces of the biomaterial and an outer surface of said tissue substrate, said energy absorbing material penetrating into the interstices of said the biomaterial, the selected one of said first and second outer surfaces of the biomaterial being capable of fusing together with the outer surface of the tissue substrate by irradiating the energy absorbing material with light energy in a predetermined wavelength range with an intensity sufficient to facilitate said fusing together.
Claim 55
Dependent Claim
147 words
A biomaterial capable of being fused onto a tissue substrate comprising: a layer of biomaterial consisting essentially of elastin having a first and second outer major surface; and an energy absorbing material, which is energy absorptive within a predetermined range of light wavelengths, applied to a selected one of said first and second outer surfaces of the biomaterial in an amount which will cause fusing together of one of said first and second outer surfaces of the biomaterial and an outer surface of said tissue substrate, said energy absorbing material penetrating into the interstices of said the biomaterial, the selected one of said first and second outer surfaces of the biomaterial being capable of fusing together with the outer surface of the tissue substrate by irradiating the energy absorbing material with light energy in a predetermined wavelength range with an intensity sufficient to facilitate said fusing together.
Claim 56
Independent Claim
60 words
A method for using a biomaterial consisting essentially of elastin, which comprises: forming a layer of a biomaterial consisting essentially of elastin having a first and second outer major surface using at lest one of said first and second outer major surface of said biomaterial layer to a human tissue substrate; and using said used biomaterial layer in biomedical applications.
Claim 57
Independent Claim
60 words
A method for using a biomaterial consisting essentially of elastin, which comprises: forming a layer of a biomaterial consisting essentially of elastin having a first and second outer major surface using at lest one of said first and second outer major surface of said biomaterial layer to a human tissue substrate; and using said used biomaterial layer in biomedical applications.
Claim 58
Dependent Claim
22 words
The method of claim 23, wherein one of said first and second outer major surfaces is fused to a human tissue substrate.
Claim 59
Dependent Claim
47 words
The method of claim 51, which further includes a step of employing said biomaterial for either one of replacement and repair of human tissue selected from a group consisting of bladders, intestines, tubes, esophagus, ureters, arteries, veins, stomachs, lungs, hearts, colons, skin, or as a cosmetic implantation.
Claim 60
Dependent Claim
35 words
The method of claim 51, which further includes the step of forming said biomaterial into a three-dimensional support structure wherein said biomaterial is combined with a stromal support matrix populated with actively growing stromal cells.
Claim 61
Dependent Claim
12 words
The method of claim 54, wherein said stromal support matrix comprise fibroblasts.
Claim 62
Dependent Claim
24 words
The method of claim 51, which further includes forming a cellular lining of human cells on one of the major surfaces of said biomaterial.
Claim 63
Dependent Claim
23 words
The method of claim 56, wherein said human cells are selected from the group consisting of endothelial cells, epithelial cells and urothelial cells.
Claim 64
Dependent Claim
32 words
The method of claim 51, which further includes the step of forming a inner lining of said biomaterial for mechanical human structures to ensure their continued internal use in a human body.
Claim 65
Dependent Claim
25 words
The method of claim 58, wherein the inner lining is employed in heart valves, heart implants, dialysis equipment, or oxygenator tubing for heart-lung by-pass systems.
Claim 66
Dependent Claim
26 words
The method of claim 51, which includes the step of incorporating a drug into said biomaterial thereby decreasing the need for systemic intravenous or oral medications.
Claim 67
Dependent Claim
24 words
The method of claim 53, which further includes forming a cellular lining of human cells on one of the major surfaces of said biomaterial.
Claim 68
Dependent Claim
23 words
The method of claim 61, wherein said human cells are selected from the group consisting of endothelial cells, epithelial cells and urothelial cells.
Claim 69
Dependent Claim
24 words
The method of claim 42, which further includes forming a cellular lining of human cells on one of the major surfaces of said biomaterial.
Claim 70
Dependent Claim
23 words
The method of claim 40, which further includes a step of employing said biomaterial for either one of replacement and repair of arteries.
Claim 71
Dependent Claim
24 words
The method of claim 64, which further includes forming a cellular lining of human cells on one of the major surfaces of said biomaterial.
Claim 72
Dependent Claim
23 words
The method of claim 65, wherein said human cells are selected from the group consisting of endothelial cells, epithelial cells and urothelial cells.
Claim 73
Dependent Claim
23 words
The method of claim 51, which further includes a step of employing said biomaterial for either one of replacement and repair of arteries.
Claim 74
Dependent Claim
24 words
The method of claim 67, which further includes forming a cellular lining of human cells on one of the major surfaces of said biomaterial.
Claim 75
Dependent Claim
23 words
The method of claim 68, wherein said human cells are selected from the group consisting of endothelial cells, epithelial cells and urothelial cells.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-08-29 | 2004-02-28 | 2004-08-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-08-29 | 2008-02-28 | 2008-08-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-08-29 | 2012-02-28 | 2012-08-29 | $7700.00 | Window Closed / Lapsed |