Patent US6369039B1 successfully refreshed from Google Patents.
US6369039B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
High efficiency local drug delivery
Assignee: Boston Scientific Corp
•
Filing: 1998-12-03
•
Granted: 2002-04-09
•
Expires: 2018-12-03
Abstract
Abstract A method of site-specifically delivering a therapeutic agent to a target location within a body cavity, vasculature or tissue. The method comprises the steps of providing a medical device having a substantially saturated solution of therapeutic agent associated therewith; introducing the medical device into the body cavity, vasculature or tissue; releasing a volume of the solution of therapeutic agent from the medical device at the target location at a pressure of from about 0 to about 5 atmospheres for a time of up to about 5 minutes; and withdrawing the medical device from the body cavity, vasculature or tissue. In another aspect, the present invention includes a system for delivering a therapeutic agent to a body cavity, vasculature or tissue, comprising a medical device having a substantially saturated solution of the therapeutic agent associated therewith.
Inventors
- 👤 Maria Palasis
- 👤 Kenneth Walsh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:40
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/104; A61P; A61P43/00; A61P9/00; A61M2025/1043; A61M2025/105
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
96 words
A method of site-specifically delivering a therapeutic agent to a target location within a body cavity, vasculature, or tissue of a mammal, comprising the steps of: providing a catheter having a substantially saturated solution of therapeutic agent associated therewith, said therapeutic agent selected from the group consisting of pharmaceutically active molecules, proteins, and nucleic acids encoding an angiogenic factor, introducing said catheter into the body cavity, vasculature, or tissue; wherein a volume of said solution of therapeutic agent is released from said catheter at the target location at a pressure not more than about 0.1 atmospheres.
Claim 2
Independent Claim
96 words
A method of site-specifically delivering a therapeutic agent to a target location within a body cavity, vasculature, or tissue of a mammal, comprising the steps of: providing a catheter having a substantially saturated solution of therapeutic agent associated therewith, said therapeutic agent selected from the group consisting of pharmaceutically active molecules, proteins, and nucleic acids encoding an angiogenic factor, introducing said catheter into the body cavity, vasculature, or tissue; wherein a volume of said solution of therapeutic agent is released from said catheter at the target location at a pressure not more than about 0.1 atmospheres.
Claim 3
Dependent Claim
14 words
The method of claim 1 , wherein said catheter is a channeled balloon catheter.
Claim 4
Dependent Claim
13 words
The method of claim 1 , wherein said catheter is a transport catheter.
Claim 5
Dependent Claim
14 words
The method of claim 1 , wherein said catheter is an infusion sleeve catheter.
Claim 6
Dependent Claim
16 words
The method of claim 1 , wherein said catheter is balloon catheter having an expandable portion.
Claim 7
Dependent Claim
28 words
The method of claim 5 , further comprising the steps of: coating said expandable portion with a polymer coating; and incorporating said therapeutic agent into said polymer coating.
Claim 8
Dependent Claim
62 words
The method of claim 6 , wherein said coating comprises a polymer selected from the group consisting of polycarboxylic acids, cellulosic polymers, gelatin, polyvinylpyrolidone, maleic anhydnde polymers, polyamides, polyvinyl alcohols, polyethylene oxides, glycosamnoglycans, polysacchaxides, polyesters, polyuretbanes, silicones, polyorthoesters, polyanhydrides, polycarbonates, polypropylenes, polylactic acids, polyglycolic acids, polycaprolactones, polybydroxybutyrate valerates, polyacrylamides, polyethers, polyurethane dispersions, acrylic latex dispersions, polyacrylic acid, and mixtures and co-polymers thereof.
Claim 9
Dependent Claim
50 words
The method of claim 5 , further comprising the steps of: placing a sheath over said expandable portion before said step of positioning said catheter to said target location; and removing said expandable portion from said sheath before said step of releasing said solution of therapeutic agent from said catheter.
Claim 10
Dependent Claim
12 words
The method of claim 1 , wherein said catheter comprises a needle.
Claim 11
Dependent Claim
14 words
The method of claim 9 , wherein said catheter is a needle injection catheter.
Claim 12
Dependent Claim
13 words
The method of claim 9 , wherein said needle is a hypodermic needle.
Claim 13
Independent Claim
130 words
A method of site-specifically delivering a therapeutic agent selected from the group consisting of therapeutically active molecules, protein and nucleic acids encoding an angiogenic factor to a target location within a body cavity or vasculature of a mammal, comprising the steps of: providing a catheter having a substantially saturated solution of therapeutic agent incorporated therein, said solution comprising a physiologically acceptable solvent and said therapeutic agent and wherein the concentration of said therapeutic agent in said solution is at least about 75% of the limit of solubility of said therapeutic agent in said solvent, introducing said catheter into the body cavity or vasculature; positioning said catheter to said target location; wherein said solution of therapeutic agent is released from said catheter at a pressure not more than about 0.1 atmospheres.
Claim 14
Independent Claim
130 words
A method of site-specifically delivering a therapeutic agent selected from the group consisting of therapeutically active molecules, protein and nucleic acids encoding an angiogenic factor to a target location within a body cavity or vasculature of a mammal, comprising the steps of: providing a catheter having a substantially saturated solution of therapeutic agent incorporated therein, said solution comprising a physiologically acceptable solvent and said therapeutic agent and wherein the concentration of said therapeutic agent in said solution is at least about 75% of the limit of solubility of said therapeutic agent in said solvent, introducing said catheter into the body cavity or vasculature; positioning said catheter to said target location; wherein said solution of therapeutic agent is released from said catheter at a pressure not more than about 0.1 atmospheres.
Claim 15
Dependent Claim
14 words
The method of claim 12 , wherein said catheter is a channeled balloon catheter.
Claim 16
Dependent Claim
13 words
The method of claim 12 , wherein said catheter is a transport catheter.
Claim 17
Dependent Claim
14 words
The method of claim 12 , wherein said catheter is an infusion sleeve catheter.
Claim 18
Dependent Claim
17 words
The method of claim 12 , wherein said catheter is a balloon catheter having an expandable portion.
Claim 19
Dependent Claim
28 words
The method of claim 16 , further comprising the steps of, coating said expandable portion with a polymer coating; and incorporating said therapeutic agent into said polymer coating.
Claim 20
Dependent Claim
62 words
The method of claim 17 , wherein said coating comprises a polymer selected from the group consisting of polycarboxylic acids, cellulosic polymers, gelatin, polyvinylpyrrolidone, maleic anhydride polymers, polyamides, polyvinyl alcohols, polyethylene oxides, glycosaminoglycans, polysaccharides, polyesters, polyurethanes, silicones, polyorthoesters, polyanhydrides, polycarbonates, polypropylenes, polylactic acids, polyglycolic acids, polycaprolactones, polyhydroxybutyrate valerates, polyacrylamides, polyethers, polyurethane dispersions, acrylic latex dispersions, polyacrylir acid, and mixtures and co-polymers thereof.
Claim 21
Dependent Claim
50 words
The method of claim 17 , further comprising the steps of placing a sheath over said expandable portion before said step of positioning said catheter to said target location; and removing said expandable portion from said sheath before said step of releasing said solution of therapeutic agent from said catheter.
References Cited (Backward Citations)
US4487808A
Cited
GB2127839A
Cited
GB2153235A
Cited
US5061237A
Cited
EP0372088A1
Cited
EP0364787B1
Cited
US5041107A
Cited
US5103817A
Cited
WO1992011896A1
Cited
US5674192A
Cited
US5102402A
Cited
US5383928A
Cited
US5599294A
Cited
US5733925A
Cited
US5981568A
Cited
US5624411A
Cited
US5380299A
Cited
US5763416A
Cited
US5464395A
Cited
US5652225A
Cited
WO1997041916A1
Cited
US6228845B1
Cited
WO1998035784A1
Cited
US5846225A
Cited
US6273913B1
Cited
US5800525A
Cited
US6251886B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-04-08 | 2005-10-08 | 2006-04-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-04-08 | 2009-10-08 | 2010-04-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-04-08 | 2013-10-08 | 2014-04-09 | $7700.00 | Window Closed / Lapsed |