Patent US3414783A successfully refreshed from Google Patents.
Patent US6328765B1 successfully refreshed from Google Patents.
US6328765B1
Expired / Lapsed
US
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Methods and articles for regenerating living tissue
Assignee: W.L. Gore and Associates Inc
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Filing: 1998-12-03
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Granted: 2001-12-11
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Expires: 2018-12-03
Abstract
Abstract There are numerous medical situations involving deficiencies of living tissue and where increase of living tissue mass is desired. Methods are described wherein a configured, shell-like device that is capable of being penetrated by living cells and tissues, is implanted into the body of a mammal in such a way as to establish a space, the space being at least partly, bounded by the device. The configuration of the device is such that the configuration of the established space is essentially the same as the configuration of living tissue that is desired for treatment of the tissue deficiency. At least one tissue stimulating molecular substance is placed within the established space for the purpose of stimulating the growth of desired living tissue within the established space. A kit for the generation of desired living tissue, comprised of the components mentioned above, is also disclosed.
Inventors
- 👤 William R. Hardwick
- 👤 Robert C. Thomson
- 👤 Robert L. Cleek
- 👤 Shrikant M. Mane
- 👤 Alonzo D. Cook
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:25
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/2846; A61F2/2803; A61L; A61L27/00; A61L27/14; A61L27/16; A61L27/18; A61L27/50; A61L27/56; A61L27/58; A61F2/30; A61F2/30767; A61F2/30907; A61F2002/2817; A61F2002/30001; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30235; A61F2/30771; A61F2002/30772; A61F2002/30784; A61F2/3094; A61F2002/30971; A61F2230/00; A61F2230/0063; A61F2230/0069; A61K; A61K38/00
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
178 words
A method of generating desired living tissue having a desired configuration in a mammal, said method comprising: providing a tissue penetrable device free of tissue stimulatory molecular substances, said device comprising portions having a plurality of holes therethrough, wherein said holes are sufficiently large to permit cells and vascular structures to grow through said tissue penetrable device, said tissue penetrable device having mechanical properties that allow the device to be configured into a desired configuration and retained substantially in said desired configuration; establishing a space with said tissue penetrable device in a mammal in such a way that a boundary is at least partially formed by said tissue penetrable device between said space and anatomical structures of said mammal surrounding said space, wherein said space has essentially the same configuration as desired living tissue to be generated therein; placing at least one tissue stimulatory molecular substance in said space; allowing cells and blood vessels from said mammal to traverse said tissue penetrable device through said holes into said space; and generating said desired living tissue in said space.
Claim 2
Independent Claim
178 words
A method of generating desired living tissue having a desired configuration in a mammal, said method comprising: providing a tissue penetrable device free of tissue stimulatory molecular substances, said device comprising portions having a plurality of holes therethrough, wherein said holes are sufficiently large to permit cells and vascular structures to grow through said tissue penetrable device, said tissue penetrable device having mechanical properties that allow the device to be configured into a desired configuration and retained substantially in said desired configuration; establishing a space with said tissue penetrable device in a mammal in such a way that a boundary is at least partially formed by said tissue penetrable device between said space and anatomical structures of said mammal surrounding said space, wherein said space has essentially the same configuration as desired living tissue to be generated therein; placing at least one tissue stimulatory molecular substance in said space; allowing cells and blood vessels from said mammal to traverse said tissue penetrable device through said holes into said space; and generating said desired living tissue in said space.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein said holes have diameters from about 3 microns to about 3,000 microns.
Claim 4
Dependent Claim
18 words
The method of claim 1 wherein said holes have diameters from about 50 microns to about 1,000 microns.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein said holes have diameters from about 150 microns to about 500 microns.
Claim 6
Dependent Claim
14 words
The method of claim 1 wherein said tissue penetrable device comprises a non-degradable material.
Claim 7
Dependent Claim
56 words
The method of claim 1 wherein said tissue penetrable device comprises a non-degradable material selected from the group consisting of polytetrafluoroethylene, perfluorinated polymers such as fluorinated ethylene propylene, silicone elastomer, polyurethane, polyethylene, polyethylene teraphthalate, polysulfone, non-degradable polycarboxylate, non-degradable polycarbonate, non-degradable polyester, polypropylene, poly(hydroxymethacrylate), polymethylmethacrylate, and polyamide such as polyesteramide, and copolymers, block copolymers, and blends thereof.
Claim 8
Dependent Claim
13 words
The method of claim 1 wherein said tissue penetrable device comprises expanded polytetrafluoroethylene.
Claim 9
Dependent Claim
14 words
The method of claim 1 wherein said tissue penetrable device comprises a degradable material.
Claim 10
Dependent Claim
50 words
The method of claim 1 wherein said tissue penetrable device comprises a degradable material selected from the group consisting of non-highly cross-linked collagen, non-highly cross-linked hyaluronic acid, hydrolyzable polyester such as polylactic acid and polyglycolic acid, polyorthoester, degradable polycarbonate, degradable polycarboxylate, polycaprolactone, polyanhydride, and copolymers, block copolymers, and blends thereof.
Claim 11
Dependent Claim
14 words
The method of claim 1 wherein said tissue penetrable device comprises poly(glycolide:trimethylene carbonate) copolymer.
Claim 12
Dependent Claim
15 words
The method of claim 1 wherein said tissue penetrable device is provided with reinforcement means.
Claim 13
Dependent Claim
12 words
The method of claim 11 wherein said reinforcement means comprises polypropylene mesh.
Claim 14
Dependent Claim
13 words
The method of claim 1 further comprising placing living cells in said space.
Claim 15
Dependent Claim
13 words
The method of claim 13 wherein said living cells are undifferentiated stem cells.
Claim 16
Dependent Claim
11 words
The method of claim 13 wherein said cells are cryopreserved cells.
Claim 17
Dependent Claim
20 words
The method of claim 1 further comprising providing said at least one tissue stimulatory molecular substance in a carrier substance.
Claim 18
Dependent Claim
29 words
The method of claim 16 wherein said carrier substance is selected from the group consisting of collagen, hyaluronic acid, calcium carbonate, tri-calcium phosphate, hydroxyapatite ceramic, magnesium sulfate, and polyester.
Claim 19
Dependent Claim
11 words
The method of claim 16 wherein said carrier substance comprises collagen.
Claim 20
Dependent Claim
12 words
The method of claim 16 wherein said carrier substance comprises hyaluronic acid.
Claim 21
Dependent Claim
26 words
The method of claim 1 further providing a matrix material within said space, said matrix material directing the functional structure of said desired living tissue generated.
Claim 22
Dependent Claim
92 words
The method of claim 1 wherein said at least one tissue stimulatory molecular substance is selected from the group consisting of: dimers of Platelet Derived Growth Factor (PDGF), insulin-like growth factor-1 (IGF-1), IGF-2, basic Fibroblast Growth Factor (bFGF), acidic FGF, Vascular Endothelial Cell Growth Factor (VEGF), Endothelial Growth Factor (EGF), Insulin, Interleukin 1 (II-1), Tumor Necrosis Factor alpha (TNF-α), Connective Tissue Growth Factor (CTGF), Transforming Growth Factor-α (TGF-α), para-thyroid hormone (PTH), prostaglandin such as Prostaglandin E-1 and Prostaglandin E-2, Macrophage Colony Stimulating Factor (MCSF), and corticosteroids such as dexamethasone, prednisolone, and corticosterone.
Claim 23
Dependent Claim
19 words
The method of claim 1 wherein said at least one tissue stimulatory molecular substance comprises a dimer of PDGF.
Claim 24
Dependent Claim
16 words
The method of claim 1 wherein said at least one tissue stimulatory molecular substance comprises IGF-1.
Claim 25
Dependent Claim
16 words
The method of claim 1 wherein said at least one tissue stimulatory molecular substance comprises bFGF.
Claim 26
Dependent Claim
17 words
The method of claim 1 wherein said at least one tissue stimulatory molecular substance comprises a corticosteroid.
Claim 27
Dependent Claim
34 words
The method of claim 1 wherein said desired living tissue is selected from the group consisting of periodontal tissue, connective tissue, muscle tissue, bone tissue, tendon tissue, ligament tissue, cartilage tissue, and adipose tissue.
Claim 28
Dependent Claim
13 words
The method of claim 1 wherein said desired living tissue is periodontal tissue.
Claim 29
Dependent Claim
13 words
The method of claim 1 wherein said desired living tissue comprises bone tissue.
Claim 30
Dependent Claim
13 words
The method of claim 1 wherein said desired living tissue comprises adipose tissue.
Claim 31
Dependent Claim
13 words
The method of claim 1 wherein said desired living tissue comprises cartilage tissue.
Claim 32
Dependent Claim
13 words
The method of claim 1 wherein said desired living tissue comprises tendon tissue.
Claim 33
Dependent Claim
13 words
The method of claim 1 wherein said desired living tissue comprises ligament tissue.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-12-10 | 2005-06-11 | 2005-12-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-12-10 | 2009-06-11 | 2009-12-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-12-10 | 2013-06-11 | 2013-12-11 | $7700.00 | Window Closed / Lapsed |