US5676699A
Expired / Lapsed
US
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Bone regeneration membrane
Assignee: SYNTHES
•
Filing: 1993-05-07
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Granted: 1997-10-14
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Expires: 2013-05-07
Abstract
Abstract A bone regeneration membrane containing resorbable or degradable, polymeric and/or polymeric-ceramic material with a glass transition temperature in the range of -30° to +200° C. The novel membrane can be used for the spontaneous regeneration of bone and for the improved application of autologous or allogenic graft materials and therapeutic agents.
Inventors
- 👤 Sylwester Gogolewski
- 👤 Richard P. Meinig
- 👤 Stephan M. Perren
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:27
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/148; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/80; A61B17/8085; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/2846; A61L2/00; A61L2/16; A61L2/20; A61L2/206; A61L31/04; A61L31/06; A61L31/12; A61L31/125; A61L31/127; A61L31/16; C; C08; C08L; C08L5/00; C08L67/00; C08L67/04; C08L73/00; C08L73/02; C08L79/00; C08L79/02; C08L89/00; A61B17/60; A61B17/64; A61B17/84; A61B17/842; A61B2017/00831; A61B2017/00867; A61F2/0077; A61F2/30; A61F2/30767; A61F2/3094; A61F2/30965; A61F2002/2835; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30092; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30235; A61F2002/30291; A61F2002/30293; A61F2002/30316; A61F2002/30329; A61F2002/30462; A61F2002/30667; A61F2002/30677; A61F2210/00; A61F2210/0004; A61F2210/0014; A61F2220/00; A61F2220/0025; A61F2220/0075; A61F2230/00; A61F2230/0063; A61F2230/0069; A61F2230/0091; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
63 words
A thin, resorbable bone regeneration membrane containing interconnected micropores and having a thickness between 0.05 mm and 5.0 mm, said membrane comprising resorbable or degradable polymeric material wherein the glass transition temperature of said polymeric material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0.
Claim 2
Dependent Claim
63 words
A thin, resorbable bone regeneration membrane containing interconnected micropores and having a thickness between 0.05 mm and 5.0 mm, said membrane comprising resorbable or degradable polymeric material wherein the glass transition temperature of said polymeric material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0.
Claim 3
Dependent Claim
27 words
A membrane according to claim 1 where said glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to +90° C.
Claim 4
Dependent Claim
25 words
A membrane according to claim 1 wherein at least 90 percent of said micropores have a diameter in the range of 0.1 to 5.0 μm.
Claim 5
Dependent Claim
27 words
A membrane according to claim 1 wherein at least 90 weight percent of said polymeric material has a molecular weight in the range of 5,000 to 1,000,000.
Claim 6
Dependent Claim
27 words
A membrane according to claim 1 wherein at least 90 weight percent of said polymeric material has a molecular weight in the range of 25,000 to 150,000.
Claim 7
Dependent Claim
34 words
A membrane according to claim 5, wherein said polymeric material is selected from the group consisting of highly purified polyhydroxyacids, polysaccharides, polyamines, polyaminoacids, polyorthoesters, polyanhydrides, collagen, and composites thereof with tricalcium phosphate and/or hydroxyapatite.
Claim 8
Dependent Claim
11 words
A membrane according to claim 1, which further contains antibiotic agents.
Claim 9
Dependent Claim
11 words
A membrane according to claim 1, which has a curved surface.
Claim 10
Dependent Claim
22 words
A membrane according to claim 8, wherein said curved surface is capable of being adapted to match the dimensions of the bone.
Claim 11
Dependent Claim
11 words
A membrane according to claim 16, which has a shape memory.
Claim 12
Dependent Claim
19 words
A membrane according to claim 9, wherein said membrane is formed into a tubular form with a longitudinal slit.
Claim 13
Dependent Claim
27 words
A membrane according to claim 11 comprising a sheet for use in surgical procedures, wherein said sheet is fashioned into a tubular form intraoperatively by the surgeon.
Claim 14
Dependent Claim
16 words
A membrane according to claim 11, comprising a sheet rolled up to form a multilayer tube.
Claim 15
Dependent Claim
21 words
A membrane according to claim 2 wherein said glass transition temperature is in the range of +40° C. to +70° C.
Claim 16
Dependent Claim
27 words
A membrane according to claim 1 wherein at least 99 weight percent of said polymeric material has a molecular weight in the range of 5,000 to 1,000,000.
Claim 17
Dependent Claim
16 words
A membrane according to claim 1 and having a thickness between 0.2 mm and 3.0 mm.
Claim 18
Dependent Claim
17 words
A membrane according to claim 16 and having a thickness of between 0.4 mm and 1.5 mm.
Claim 19
Dependent Claim
27 words
A membrane according to claim 5 wherein at least 90 weight percent of said polymeric material has a molecular weight in the range of 30,000 to 70,000.
Claim 20
Dependent Claim
26 words
A membrane according to claim 8, wherein said membrane has a surface defined by the movement of a substantially straight line along a curved planar path.
Claim 21
Dependent Claim
11 words
A membrane according to claim 9 wherein said surface is cylindrical.
Claim 22
Dependent Claim
29 words
A membrane according to claim 12 wherein said tubular form is adapted to be modified intraoperatively by a surgeon applying said membrane to match the dimensions of the bone.
Claim 23
Dependent Claim
22 words
A membrane according to claim 1 wherein said polymeric material has a molecular weight distribution in the range of 1.9 to 2.5.
Claim 24
Dependent Claim
65 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, and further comprising reinforcement including resorbable and/or degradable fibers.
Claim 25
Dependent Claim
65 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, and further comprising reinforcement including resorbable and/or degradable fibers.
Claim 26
Dependent Claim
63 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane further contains antiosteomyelitis agents.
Claim 27
Dependent Claim
63 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane further contains antiosteomyelitis agents.
Claim 28
Dependent Claim
63 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane further contains antineoplastic agents.
Claim 29
Dependent Claim
63 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane further contains antineoplastic agents.
Claim 30
Dependent Claim
70 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane further contains osteoconductive agents of autogenic, allogenic, xenogenic, or synthetic origin.
Claim 31
Dependent Claim
70 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane further contains osteoconductive agents of autogenic, allogenic, xenogenic, or synthetic origin.
Claim 32
Dependent Claim
70 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane further contains osteoinductive agents of autogenic, allogenic, xenogenic, or synthetic origin.
Claim 33
Dependent Claim
70 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane further contains osteoinductive agents of autogenic, allogenic, xenogenic, or synthetic origin.
Claim 34
Dependent Claim
89 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane is formed in a tubular form with a longitudinal slit adapted to form semi-occlusive fits at the two extremities of the tube formed by said membrane for fixation to bones.
Claim 35
Dependent Claim
89 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane is formed in a tubular form with a longitudinal slit adapted to form semi-occlusive fits at the two extremities of the tube formed by said membrane for fixation to bones.
Claim 36
Dependent Claim
89 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane is formed in a tubular form with a longitudinal slit having ends shaped to form semi-occlusive fits over cortical bone ends and within medullary canals of long or tubular bones.
Claim 37
Dependent Claim
89 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material wherein the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0, said membrane having interconnected micropores therein, wherein said membrane is formed in a tubular form with a longitudinal slit having ends shaped to form semi-occlusive fits over cortical bone ends and within medullary canals of long or tubular bones.
Claim 38
Dependent Claim
59 words
A thin, resorbable bone regeneration membrane containing interconnected micropores and having a thickness between 0.05 mm and 5.0 mm, said membrane consisting of resorbable or degradable polymeric material having a glass transition temperature in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0.
Claim 39
Dependent Claim
59 words
A thin, resorbable bone regeneration membrane containing interconnected micropores and having a thickness between 0.05 mm and 5.0 mm, said membrane consisting of resorbable or degradable polymeric material having a glass transition temperature in the range of body temperature to 200° C. and the molecular weight distribution of said polymeric material is in the range of 1.2 to 100.0.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-10-13 | 2001-04-14 | 2001-10-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-10-13 | 2005-04-14 | 2005-10-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-10-13 | 2009-04-14 | 2009-10-14 | $7700.00 | Window Closed / Lapsed |