US6296809B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Automated molecular pathology apparatus having independent slide heaters
Assignee: Ventana Medical Systems Inc
•
Filing: 1999-02-26
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Granted: 2001-10-02
•
Expires: 2019-02-26
Abstract
Abstract Apparatus and methods for automatically staining or treating multiple tissue samples mounted on microscope slides are provided. Individualized slide temperature control is accomplished by the heating system according to the present invention that has thermal platforms radially mounted to the carousel for heating the slides and sensing the temperature of each. The heating system also permits automated de-waxing if necessary.
Inventors
- 👤 William Richards
- 👤 Charles D. Lemme
- 👤 Kimberly Christensen
- 👤 Ethel R. Macrea
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 07:46
CPC Classifications
G; G01; G01N; G01N35/00; G01N35/10; G01N35/1002; G01N1/00; G01N1/28; G01N1/30; G01N1/31; G01N1/312; G01N1/36; G01N35/1079
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
153 words
Apparatus for temperature control of biological materials comprising: a plurality of heating devices, each of said plurality of heating devices adapted to receive a slide and each of said plurality of heating devices including a heater and a sensor; a movable heating device support, each of said plurality of heating devices being located on said movable heating device support; and control electronics mounted to said movable heating device support and electrically connected to each said heater and each said sensor of said plurality of heating devices, said control electronics receiving data from each said sensor of said plurality of heating devices and independently controlling each said heater of each of said plurality of heating devices as a function of data from a respective one of each-said sensor of said plurality of heating devices and as a function of respective set point temperature data for a respective slide as stored in said control electronics.
Claim 2
Dependent Claim
153 words
Apparatus for temperature control of biological materials comprising: a plurality of heating devices, each of said plurality of heating devices adapted to receive a slide and each of said plurality of heating devices including a heater and a sensor; a movable heating device support, each of said plurality of heating devices being located on said movable heating device support; and control electronics mounted to said movable heating device support and electrically connected to each said heater and each said sensor of said plurality of heating devices, said control electronics receiving data from each said sensor of said plurality of heating devices and independently controlling each said heater of each of said plurality of heating devices as a function of data from a respective one of each-said sensor of said plurality of heating devices and as a function of respective set point temperature data for a respective slide as stored in said control electronics.
Claim 3
Dependent Claim
21 words
Apparatus for temperature control of biological materials as claimed in claim 1 wherein the movable heating device support is a carousel.
Claim 4
Dependent Claim
34 words
Apparatus for temperature control of biological materials as claimed in claim 1 wherein each of said plurality of heating devices further includes a housing, the housing being mounted to the movable heating device support.
Claim 5
Dependent Claim
43 words
Apparatus for temperature control of biological materials as claimed in claim 3 wherein the housing includes a skirt, the skirt having an upper end which supports the heater and also having a lower end which is mounted to the movable heating device support.
Claim 6
Dependent Claim
22 words
Apparatus for temperature control of biological materials as claimed in claim 4 wherein the skirt is composed of a thermally insulative material.
Claim 7
Dependent Claim
17 words
Apparatus for temperature control of biological materials as claimed in claim 5 wherein the skirt is rubber.
Claim 8
Dependent Claim
34 words
Apparatus for temperature control of biological materials as claimed in claim 1 wherein each of said plurality of heating devices further includes a plate adjacent to the heater and adapted for supporting the slide.
Claim 9
Dependent Claim
19 words
Apparatus for temperature control of biological materials as claimed in claim 7 wherein the plate is composed of brass.
Claim 10
Dependent Claim
45 words
Apparatus for temperature control of biological materials as claimed in claim 1 wherein each of said plurality of heating devices is mounted on a respective thermal platform and disposed on the movable heating device support, wherein the thermal platforms are thermally isolated from one another.
Claim 11
Dependent Claim
32 words
Apparatus for temperature control of biological materials as claimed in claim 9 wherein thermally resistant material is located between each of the plurality of heating devices and the movable heating device support.
Claim 12
Dependent Claim
32 words
Apparatus for temperature control of biological materials as claimed in claim 9 wherein thermally resistant material is mounted on the movable heating device-support in between each of the plurality of heating devices.
Claim 13
Dependent Claim
66 words
Apparatus for temperature control of biological materials as claimed in claim 1 wherein the control electronics compares the received data from each said sensor with said respective set point temperature data for a respective slide as stored in said control electronics and wherein the control electronics controls each said heater based on the comparison in order to independently control each of said plurality of heating devices.
Claim 14
Dependent Claim
54 words
Apparatus for temperature control of biological materials as claimed in claim 12 wherein the control electronics modifies duty cycles of each of the plurality of heaters based on the comparison of the received data from each said sensor with said-respective set point temperature data for a respective slide as stored in said control electronics.
Claim 15
Dependent Claim
59 words
Apparatus for temperature control of biological materials as claimed in claim 1 wherein the control electronics modifies power sent to said respective one of each said heater based on comparison of the data received from said respective one of each said sensor with said respective set point temperature data for said respective slide as stored in said control electronics.
Claim 16
Dependent Claim
26 words
Apparatus for temperature control of biological materials as claimed in claim 14 wherein the control electronics includes at least one processor and at least one driver.
Claim 17
Dependent Claim
48 words
Apparatus for temperature control of biological materials as claimed in claim 15 wherein the processor for the control electronics compares the data received from said respective one of each said sensor with said respective set point temperature data for said respective slide as stored in said control electronics.
Claim 18
Dependent Claim
31 words
Apparatus for temperature control of biological materials as claimed in claim 15 wherein the at least one driver supplies power to at least one heater of said plurality of heating devices.
Claim 19
Dependent Claim
43 words
Apparatus for temperature control of biological materials as claimed in claim 1 further comprising a processor which sends said respective set point temperature data to the control electronics, the processor being mounted on a fixed assembly external to the movable heating device support.
Claim 20
Dependent Claim
131 words
Apparatus for temperature control of biological materials comprising: a plurality of thermal platforms, each thermal platform comprising a heater, a sensor, a slide support and a housing, each thermal platform adapted for receiving a slide on the slide support; a thermal platform support, the thermal platform support being movable, and each of the plurality of thermal platforms being located on the thermal platform support; and control electronics mounted on the thermal platform support and electrically connected to each of the plurality of thermal platforms and receiving temperature data from each said sensor and individually controlling the heater of each of the plurality of thermal platforms based upon temperature data from the sensor of each of the plurality of thermal platforms and based upon respective set point temperature data for each slide.
Claim 21
Dependent Claim
131 words
Apparatus for temperature control of biological materials comprising: a plurality of thermal platforms, each thermal platform comprising a heater, a sensor, a slide support and a housing, each thermal platform adapted for receiving a slide on the slide support; a thermal platform support, the thermal platform support being movable, and each of the plurality of thermal platforms being located on the thermal platform support; and control electronics mounted on the thermal platform support and electrically connected to each of the plurality of thermal platforms and receiving temperature data from each said sensor and individually controlling the heater of each of the plurality of thermal platforms based upon temperature data from the sensor of each of the plurality of thermal platforms and based upon respective set point temperature data for each slide.
Claim 22
Dependent Claim
69 words
Apparatus for temperature control of biological materials as claimed in claim 19 wherein each of said plurality of thermal platforms further includes a housing and, the housing includes a skirt, the skirt having an upper end which supports the slide support and also having a lower end which is mounted to the thermal platform support so that the slide support is raised with respect to the thermal platform support.
Claim 23
Dependent Claim
66 words
Apparatus for temperature control of biological materials as claimed in claim 19 wherein the control electronics compares the temperature data from each said sensor with said respective set point temperature data for a respective slide as stored in said control electronics and wherein the control electronics controls each said heater based on the comparison in order to individually control each of said plurality of thermal platforms.
Claim 24
Dependent Claim
44 words
Apparatus for temperature control of biological materials as claimed in claim 21 wherein the control electronics modifies duty cycles of each said heater based on the comparison of the temperature data from each said sensor with said respective setpoint temperature data for the slide.
Claim 25
Dependent Claim
41 words
Apparatus for temperature control of biological materials as claimed in claim 19 wherein the control electronics modifies power to the heater based on comparison of the temperature data from the sensor with the respective set point temperature data for the slide.
Claim 26
Dependent Claim
26 words
Apparatus for temperature control of biological materials as claimed in claim 23 wherein the control electronics includes at least one processor and at least one driver.
Claim 27
Dependent Claim
36 words
Apparatus for temperature control of biological materials as claimed in claim 24 wherein the processor for the control electronics compares the temperature data from the sensor with the respective set point temperature data for the slide.
Claim 28
Dependent Claim
31 words
Apparatus for temperature control of biological materials as claimed in claim 24 wherein the at least one driver supplies power to at least one heater of the plurality of thermal platforms.
Claim 29
Dependent Claim
43 words
Apparatus for temperature control of biological materials as claimed in claim 19 further comprising a processor which sends the respective set point temperature data to the control electronics, the processor being mounted on a fixed assembly external to the movable heating device support.
References Cited (Backward Citations)
US3979576A
Cited
US3853092A
Cited
US4043292A
Cited
US4092952A
Cited
US4358470A
Cited
US4543236A
Cited
US4647431A
Cited
US4384193A
Cited
US4430299A
Cited
US4629862A
Cited
US4731335B1
Cited
US4731335A
Cited
US4695430A
Cited
US4858155A
Cited
US4933146A
Cited
US5154889A
Cited
US4847208A
Cited
US5073504A
Cited
US4985206A
Cited
US4865986A
Cited
US5105066A
Cited
US5093557A
Cited
US5231029A
Cited
US5089229A
Cited
US5595707A
Cited
US6180060B1
Cited
US5207987A
Cited
US5075079A
Cited
US5425918A
Cited
US5475610A
Cited
US5280156A
Cited
US5273905A
Cited
US5246665A
Cited
WO1993009486A1
Cited
US5819842A
Cited
US5645114A
Cited
US5316452A
Cited
US5947167A
Cited
US5314825A
Cited
US5601141A
Cited
US5439649A
Cited
US5496518A
Cited
US5523056A
Cited
US5985672A
Cited
US6096271A
Cited
US6183693B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-10-01 | 2005-04-02 | 2005-10-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-10-01 | 2009-04-02 | 2009-10-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-10-01 | 2013-04-02 | 2013-10-02 | $7700.00 | Window Closed / Lapsed |