US6287628B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Porous prosthesis and a method of depositing substances into the pores
Assignee: Abbott Cardiovascular Systems Inc
•
Filing: 1999-09-03
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Granted: 2001-09-11
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Expires: 2019-09-03
Abstract
Abstract A porous implantable prosthesis is loaded with a substance for subsequent application to biological tissues. A method according to loading the substance to the porous prosthesis is provided. A first fluid in combination with an added substance is applied to the porous prosthesis. During the application, the first fluid containing the substance is capable of penetrating into prosthesis pores. The first fluid is removed and a second fluid is applied to the prosthesis. The second fluid is not capable of significantly penetrating into the pores. Prior to the application of the second fluid, the prosthesis can be immersed in a third fluid and agitated via mechanical perturbation techniques so that any of the substance gathered on the surface of the body, after the application of the first fluid, is removed. The third fluid should not be capable of dissolving the substance.
Inventors
- 👤 Syed F. A. Hossainy
- 👤 Li Chen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:11
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/16; A61L31/146; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/90; A61F2/91
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
127 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said pores; removing said first fluid from said prosthesis; applying a second fluid to said prosthesis to remove said substance from said surface of said prosthesis, wherein said second fluid has a contact angle greater than about 90° so as to prevent said second fluid from significantly penetrating into said pores to remove said substance out from said pores during the application of said second fluid; and removing said second fluid from said prosthesis, wherein said substance is deposited into said pores.
Claim 2
Independent Claim
127 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said pores; removing said first fluid from said prosthesis; applying a second fluid to said prosthesis to remove said substance from said surface of said prosthesis, wherein said second fluid has a contact angle greater than about 90° so as to prevent said second fluid from significantly penetrating into said pores to remove said substance out from said pores during the application of said second fluid; and removing said second fluid from said prosthesis, wherein said substance is deposited into said pores.
Claim 3
Dependent Claim
33 words
The method according to claim 1 , wherein said acts of removing said first fluid and said second fluid comprise allowing said first fluid and said second fluid to evaporate from said prosthesis.
Claim 4
Dependent Claim
69 words
The method according to claim 1 , additionally comprising prior to said act of applying said second fluid: immersing said prosthesis in a third fluid, wherein said substance does not significantly dissolve in said third fluid; agitating said prosthesis in said third fluid to significantly remove said substance from said surface of said prosthesis, wherein said substance remains in said pores; and removing said prosthesis from said third fluid.
Claim 5
Dependent Claim
19 words
The method according to claim 3 , wherein said third fluid has a contact angle greater than about 90°.
Claim 6
Dependent Claim
15 words
The method according to claim 1 , wherein said substance is a first therapeutic substance.
Claim 7
Dependent Claim
75 words
The method according to claim 5 , additionally comprising, prior to said act of applying said second fluid: immersing said prosthesis in a third fluid, wherein said first therapeutic substance does not significantly dissolve in said third fluid; agitating said prosthesis in said third fluid to significantly remove said first therapeutic substance from said surface of said prosthesis, wherein said first therapeutic substance remains in said pores; and removing said prosthesis from said third fluid.
Claim 8
Dependent Claim
19 words
The method according to claim 6 , wherein said third fluid has a contact angle greater than about 90°.
Claim 9
Dependent Claim
45 words
The method according to claim 5 , wherein said second fluid comprises a second therapeutic substance added thereto, such that after said act of removing said second fluid from said prosthesis, a coating of said second therapeutic substance remains on said surface of said prosthesis.
Claim 10
Dependent Claim
20 words
The method according to claim 8 , wherein said second therapeutic substance is the same as the first therapeutic substance.
Claim 11
Dependent Claim
19 words
The method according to claim 8 , wherein said second therapeutic substance is different than said first therapeutic substance.
Claim 12
Dependent Claim
43 words
The method according to claim 1 , wherein said second fluid comprises a polymeric material added thereto, such that after said act of removing said second fluid from said prosthesis, a coating of said polymeric material remains on said surface of said prosthesis.
Claim 13
Dependent Claim
54 words
The method according to claim 1 , wherein said second fluid comprises a combination of a polymeric material and a therapeutic substance added thereto, such that after said act of removing said second fluid from said prosthesis, a coating of said polymeric material containing said therapeutic substance remains of said surface of said prosthesis.
Claim 14
Dependent Claim
14 words
The method according to claim 1 , wherein said substance includes a polymeric material.
Claim 15
Dependent Claim
20 words
The method according to claim 13 , wherein said polymeric material significantly dissolves when in contact with said second fluid.
Claim 16
Dependent Claim
72 words
The method according to claim 13 , additionally comprising, prior to said act of applying said second fluid: immersing said prosthesis in a third fluid, wherein said polymeric material does not significantly dissolve in said third fluid; agitating said prosthesis in said third fluid to significantly remove said polymeric material from said surface of said prosthesis, wherein said polymeric material remains in said pores; and removing said prosthesis from said third fluid.
Claim 17
Dependent Claim
19 words
The method according to claim 15 , wherein said third fluid has a contact angle greater than about 90°.
Claim 18
Dependent Claim
31 words
The method according to claim 13 , wherein said polymeric material is a non-thermoplastic polymer and the method additionally comprises the act of curing said non-thermoplastic polymer deposited in said pores.
Claim 19
Dependent Claim
18 words
The method according to claim 1 , wherein said substance includes a polymeric material and a therapeutic substance.
Claim 20
Dependent Claim
84 words
The method according to claim 18 , additionally comprising, prior to said act of applying said second fluid: immersing said prosthesis in a third fluid, wherein said polymeric material and said therapeutic substance do not significantly dissolve in said third fluid; agitating said prosthesis in said third fluid to significantly remove said polymeric material and said therapeutic substance from said surface of said prosthesis, wherein said polymeric material containing said therapeutic substance remains in said pores; and removing said prosthesis from said third fluid.
Claim 21
Dependent Claim
19 words
The method according to claim 19 , wherein said third fluid has a contact angle greater than about 90°.
Claim 22
Dependent Claim
14 words
The method according to claim 1 , wherein said substance is a radioactive isotope.
Claim 23
Dependent Claim
52 words
The method according to claim 21 , additionally comprising prior to said act of applying said second fluid: immersing said prosthesis in a third fluid; agitating said prosthesis in said third fluid to significantly remove said radioactive isotope from said surface of said prosthesis; and removing said prosthesis from said third fluid.
Claim 24
Dependent Claim
19 words
The method according to claim 22 , wherein said third fluid has a contact angle greater than about 90°.
Claim 25
Dependent Claim
14 words
The method according to claim 1 , wherein said substance is a radiopaque material.
Claim 26
Dependent Claim
26 words
The method according to claim 24 , additionally comprising, subsequent to said act of removing said second fluid, sintering said radiopaque material deposited in said pores.
Claim 27
Dependent Claim
52 words
The method according to claim 24 , additionallt comprising prior to said act of applying said second fluid: immersing and prosthesis in a third fluid; agitating said prosthesis in said third fluid to significantly remove said radiopaque material from said surface of said prosthesis; and removing said prosthesis from said third fluid.
Claim 28
Dependent Claim
19 words
The method according to claim 26 , wherein said third fluid has a contact angle greater than about 90°.
Claim 29
Independent Claim
109 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said pores; removing said first fluid from said prosthesis; applying a second fluid to said prosthesis, wherein during said act of applying said second fluid, said second fluid does not significantly penetrate into said pores; and removing said second fluid from said prosthesis, wherein said substance is deposited into said pores, and wherein said substance significantly dissolves when in contact with said second fluid.
Claim 30
Independent Claim
109 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said pores; removing said first fluid from said prosthesis; applying a second fluid to said prosthesis, wherein during said act of applying said second fluid, said second fluid does not significantly penetrate into said pores; and removing said second fluid from said prosthesis, wherein said substance is deposited into said pores, and wherein said substance significantly dissolves when in contact with said second fluid.
Claim 31
Independent Claim
117 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said pores; removing said first fluid from said prosthesis; applying a second fluid to said prosthesis, wherein during said act of applying said second fluid, said second fluid does not significantly penetrate into said pores; and removing said second fluid from said prosthesis, wherein said substance is deposited into said pores, wherein said substance is a therapeutic substance, and wherein said therapeutic substance significantly dissolves when in contact with said second fluid.
Claim 32
Independent Claim
117 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said pores; removing said first fluid from said prosthesis; applying a second fluid to said prosthesis, wherein during said act of applying said second fluid, said second fluid does not significantly penetrate into said pores; and removing said second fluid from said prosthesis, wherein said substance is deposited into said pores, wherein said substance is a therapeutic substance, and wherein said therapeutic substance significantly dissolves when in contact with said second fluid.
Claim 33
Dependent Claim
19 words
The method according to claim 29 , wherein said second fluid has a contact angle greater than about 90°.
Claim 34
Dependent Claim
24 words
The method according to claim 29 , wherein said second fluid has a boiling point not greater than about 60° C. at 1 atm.
Claim 35
Independent Claim
145 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said pores; removing said first fluid from said prosthesis; applying a second fluid to said prosthesis, wherein during said act of applying said second fluid, said second fluid does not significantly penetrate into said pores; and removing said second fluid from said prosthesis, wherein said substance is deposited into said pores, wherein said substance includes a polymeric material and a therapeutic substance, and wherein said polymeric material and said therapeutic substance dissolve when in contact with said second fluid such that any of said polymeric material and said therapeutic substance disposed on said surface of said prosthesis are significantly removed.
Claim 36
Independent Claim
145 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said pores; removing said first fluid from said prosthesis; applying a second fluid to said prosthesis, wherein during said act of applying said second fluid, said second fluid does not significantly penetrate into said pores; and removing said second fluid from said prosthesis, wherein said substance is deposited into said pores, wherein said substance includes a polymeric material and a therapeutic substance, and wherein said polymeric material and said therapeutic substance dissolve when in contact with said second fluid such that any of said polymeric material and said therapeutic substance disposed on said surface of said prosthesis are significantly removed.
Claim 37
Independent Claim
147 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said pores; removing said first fluid from said prosthesis; applying a second fluid to said prosthesis, wherein during said act of applying said second fluid, said second fluid does not significantly penetrate into said pores; and removing said second fluid from said prosthesis, wherein said substance is deposited into said pores, wherein said substance includes a polymeric material and a therapeutic substance, and wherein said therapeutic substance dissolves when in contact with said second fluid, wherein after said act of removing said second fluid a coating made from said polymeric material remains on said surface of said prosthesis and covers said pores.
Claim 38
Independent Claim
147 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said pores; removing said first fluid from said prosthesis; applying a second fluid to said prosthesis, wherein during said act of applying said second fluid, said second fluid does not significantly penetrate into said pores; and removing said second fluid from said prosthesis, wherein said substance is deposited into said pores, wherein said substance includes a polymeric material and a therapeutic substance, and wherein said therapeutic substance dissolves when in contact with said second fluid, wherein after said act of removing said second fluid a coating made from said polymeric material remains on said surface of said prosthesis and covers said pores.
Claim 39
Dependent Claim
19 words
The method according to claim 33 , wherein said second fluid has a contact angle greater than about 90°.
Claim 40
Independent Claim
106 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid and said substance penetrate into said pores; allowing said first fluid to evaporate; applying a second fluid to said prosthesis to remove said substance from said surface of said prosthesis, wherein said second fluid has a boiling point of not greater than about 60° C. at 1 atm; and allowing said second fluid to evaporate, wherein said substance is deposited into said pores.
Claim 41
Independent Claim
106 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid and said substance penetrate into said pores; allowing said first fluid to evaporate; applying a second fluid to said prosthesis to remove said substance from said surface of said prosthesis, wherein said second fluid has a boiling point of not greater than about 60° C. at 1 atm; and allowing said second fluid to evaporate, wherein said substance is deposited into said pores.
Claim 42
Independent Claim
104 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid and said substance penetrate into said pores; allowing said first fluid to evaporate; applying a second fluid to said prosthesis to remove said substance from said surface of said prosthesis, wherein said second fluid has a viscosity not less than about 1.0 centipoise at room temperature; and allowing said second fluid to evaporate, wherein said substance is deposited into said pores.
Claim 43
Independent Claim
104 words
A method of loading a substance into pores of an implantable prosthesis: providing a prosthesis having a surface and pores formed in said surface; applying a first fluid including a substance to said prosthesis, wherein during said act of applying, said first fluid and said substance penetrate into said pores; allowing said first fluid to evaporate; applying a second fluid to said prosthesis to remove said substance from said surface of said prosthesis, wherein said second fluid has a viscosity not less than about 1.0 centipoise at room temperature; and allowing said second fluid to evaporate, wherein said substance is deposited into said pores.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-09-10 | 2005-03-12 | 2005-09-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-09-10 | 2009-03-12 | 2009-09-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-09-10 | 2013-03-12 | 2013-09-11 | $7700.00 | Window Closed / Lapsed |