US6120847A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Surface treatment method for stent coating
Assignee: Boston Scientific Scimed Inc
•
Filing: 1999-01-08
•
Granted: 2000-09-19
•
Expires: 2019-01-08
Abstract
Abstract A method is provided for eliminating surface imperfections on a medical device having a drug release coating including a therapeutic substance in a polymeric carrier disposed on at least a portion of the medical device. The medical device is preferably a stent including wire-like members interconnected to form struts with open interstices therebetween. A therapeutic substance incorporate into a polymeric carrier is disposed on the surface of the stent through which process imperfections including polymeric fibers, polymeric particles or other polymeric surface aberrations or imperfections are formed. This imperfections are eliminated by contacting the polymeric coating with a vaporized solvent for a specified period of time.
Inventors
- 👤 Dachuan Yang
- 👤 Carmen Jacob
- 👤 Lixiao Wang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:29
CPC Classifications
B; B05; B05D; B05D3/00; B05D3/12; A; A61; A61L; A61L31/00; A61L31/08; A61L31/10
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
86 words
A method for eliminating polymeric fibers, polymeric particles or other polymeric surface aberrations or imperfections from a polymeric coating on a medical device, the method comprising the steps of: providing a medical device having a surface generally defined by a skeletal frame having spaces therebetween, wherein at least a portion of said surface is coated with a polymeric material, some of said polymeric material extending across said spaces; and, contacting said polymeric coating with a vaporized solvent, thereby eliminating said polymeric material extending across said spaces.
Claim 2
Independent Claim
86 words
A method for eliminating polymeric fibers, polymeric particles or other polymeric surface aberrations or imperfections from a polymeric coating on a medical device, the method comprising the steps of: providing a medical device having a surface generally defined by a skeletal frame having spaces therebetween, wherein at least a portion of said surface is coated with a polymeric material, some of said polymeric material extending across said spaces; and, contacting said polymeric coating with a vaporized solvent, thereby eliminating said polymeric material extending across said spaces.
Claim 3
Dependent Claim
18 words
The method of claim 1, wherein said polymeric material is at least partially soluble in said vaporized solvent.
Claim 4
Dependent Claim
46 words
The method of claim 2, wherein said polymeric material is contacted with said vaporized solvent for between about 0.5 seconds to about 2 hours to thereby eliminate surface fibers, surface particles or other surface aberrations without abrogating the integrity of said polymeric coating over said surface.
Claim 5
Dependent Claim
13 words
The method of claim 2, wherein said vaporized solvent is an organic solvent.
Claim 6
Dependent Claim
33 words
The method of claim 4, wherein said organic solvent is selected from the group consisting of hydrocarbons, polyethers, halocarbons, alkyl amides, cyclic ethers, ethyl acetate, benzene, alkyl-substituted benzene derivatives, alcohols, and combinations thereof.
Claim 7
Dependent Claim
29 words
The method of claim 1, wherein said polymeric coating is selected from the group consisting of polyethylene oxide (PEO), polylactic acid, polyglycolic acid, polycaprolactone, polyurethane, polysiloxane and their copolymers.
Claim 8
Dependent Claim
16 words
The method of claim 1, wherein said polymeric coating includes a therapeutic agent releasably incorporated therein.
Claim 9
Dependent Claim
27 words
The method of claim 7, wherein said therapeutic agent is selected from the group consisting of an anti-thrombogenic agent, an anti-angiogenesis agent, heparin, hirudin, ticlopidine, and Taxol.
Claim 10
Dependent Claim
21 words
The method of claim 1, wherein said contact between said polymeric coating and said vaporized solvent occurs through a dipping process.
Claim 11
Dependent Claim
21 words
The method of claim 1, wherein said contact between said polymeric coating and said vaporized solvent occurs through a spraying process.
Claim 12
Independent Claim
121 words
A method of coating a medical device with a polymeric material wherein said coating is generally free of polymeric strands, polymeric particles or other polymeric surface aberrations, said method comprising the steps of: providing a medical device having a surface generally defined by a plurality of interconnected stunts with open interstitial spaces therebetween, coating at least a portion of said surface with a polymeric material in a solvent carrier; drying said polymeric material by evaporating at least a portion of said solvent carrier to form a dried polymeric coating, wherein some of said dried polymeric material extends across said interstitial spaces; and, contacting said dried polymeric coating with a vaporized solvent, thereby eliminating said polymeric material extending across said interstitial spaces.
Claim 13
Independent Claim
121 words
A method of coating a medical device with a polymeric material wherein said coating is generally free of polymeric strands, polymeric particles or other polymeric surface aberrations, said method comprising the steps of: providing a medical device having a surface generally defined by a plurality of interconnected stunts with open interstitial spaces therebetween, coating at least a portion of said surface with a polymeric material in a solvent carrier; drying said polymeric material by evaporating at least a portion of said solvent carrier to form a dried polymeric coating, wherein some of said dried polymeric material extends across said interstitial spaces; and, contacting said dried polymeric coating with a vaporized solvent, thereby eliminating said polymeric material extending across said interstitial spaces.
Claim 14
Dependent Claim
46 words
The method of claim 11, wherein said polymeric material is contacted with said vaporized solvent for between about 0.5 seconds to about 2 hours to thereby eliminate surface fibers, surface particles or other surface aberrations without abrogating the integrity of said polymeric coating over said surface.
Claim 15
Dependent Claim
13 words
The method of claim 11, wherein said vaporized solvent is an organic solvent.
Claim 16
Dependent Claim
30 words
The method of claim 13, wherein said organic solvent is selected from the group consisting of hydrocarbons, polyethers, cyclic ethers, ethyl acetate, benzene, alkyl-substituted benzene derivatives, alcohols, and combinations thereof.
Claim 17
Dependent Claim
30 words
The method of claim 11, wherein said polymeric coating is selected from the group consisting of polyethylene oxide (PEO), polylactic acid, polyclycolic acid, and polycaprolactone, polyurethane, polysiloxane and their copolymers.
Claim 18
Independent Claim
137 words
A method for coating a stent with a polymeric material having a therapeutic substance dispersed therein for timed release of said therapeutic substance when said stent is implanted wherein said coating is generally free of polymeric strands, polymeric particles or other polymeric surface aberrations, said method comprising the steps of: providing a stent having a surface generally defined by a plurality of interconnected struts with open interstitial spaces therebetween; coating at least a portion of said surface with a polymeric material in a solvent carrier; drying said polymeric material by evaporating at least a portion of said solvent carrier to form a dried polymeric coating, wherein some of said dried polymeric material extends across said interstitial spaces; and, contacting said dried polymeric coating with a vaporized solvent, thereby eliminating said polymeric material extending across said interstitial spaces.
Claim 19
Independent Claim
137 words
A method for coating a stent with a polymeric material having a therapeutic substance dispersed therein for timed release of said therapeutic substance when said stent is implanted wherein said coating is generally free of polymeric strands, polymeric particles or other polymeric surface aberrations, said method comprising the steps of: providing a stent having a surface generally defined by a plurality of interconnected struts with open interstitial spaces therebetween; coating at least a portion of said surface with a polymeric material in a solvent carrier; drying said polymeric material by evaporating at least a portion of said solvent carrier to form a dried polymeric coating, wherein some of said dried polymeric material extends across said interstitial spaces; and, contacting said dried polymeric coating with a vaporized solvent, thereby eliminating said polymeric material extending across said interstitial spaces.
Claim 20
Dependent Claim
18 words
The method of claim 16, wherein said polymeric material is at least partially soluble in said vaporized solvent.
Claim 21
Dependent Claim
46 words
The method of claim 17, wherein said polymeric material is contacted with said vaporized solvent for between about 0.5 seconds to about 2 hours to thereby eliminate surface fibers, surface particles or other surface aberrations without abrogating the integrity of said polymeric coating over said surface.
Claim 22
Dependent Claim
13 words
The method of claim 17, wherein said vaporized solvent is an organic solvent.
Claim 23
Dependent Claim
33 words
The method of claim 19, wherein said organic solvent is selected from the group consisting of hydrocarbons, polyethers, halocarbons, alkyl amides, cyclic ethers, ethyl acetate, benzene, alkyl-substituted benzene derivatives, alcohols, and combinations thereof.
Claim 24
Dependent Claim
29 words
The method of claim 16, wherein said polymeric coating is selected from the group consisting of polyethylene oxide (PEO), polylactic acid, polyglycolic acid, polycaprolactone, polyurethane, polysiloxane, and their copolymers.
Claim 25
Dependent Claim
21 words
The method of claim 16, wherein said contact between said polymeric coating and said vaporized solvent occurs through a dipping process.
Claim 26
Dependent Claim
21 words
The method of claim 16, wherein said contact between said polymeric coating and said vaporized solvent occurs through a spraying process.
Claim 27
Dependent Claim
18 words
The method of claim 16, wherein said therapeutic substances include anti-proliferative agents, anti-thrombogenic agents, or a combination thereof.
Claim 28
Dependent Claim
19 words
The method of claim 16, wherein said therapeutic substance in said polymeric material is contacted with said vaporized solvent.
References Cited (Backward Citations)
US2282274A
Cited
US3525634A
Cited
US3527650A
Cited
US3676171A
Cited
US3684553A
Cited
US3737499A
Cited
US4027676A
Cited
US4391797A
Cited
US4302418A
Cited
US4459317A
Cited
US4487808A
Cited
US4525409A
Cited
US4770664A
Cited
US5569469A
Cited
US4923464A
Cited
US5102417A
Cited
US4768507A
Cited
EP0274846B1
Cited
US5092885A
Cited
EP0294905A1
Cited
US5527337A
Cited
US4969890A
Cited
US5019096A
Cited
WO1990001969A1
Cited
WO1990013332A1
Cited
US4994071A
Cited
WO1991007154A1
Cited
WO1991010424A1
Cited
WO1991011193A1
Cited
WO1991012779A1
Cited
US5545208A
Cited
EP0470246B1
Cited
US5569463A
Cited
US5447724A
Cited
WO1992000747A1
Cited
EP0470569A1
Cited
US5222971A
Cited
US5449372A
Cited
US5304121A
Cited
WO1992012717A2
Cited
WO1992015286A1
Cited
US5512055A
Cited
WO1993006792A1
Cited
US5514154A
Cited
EP0543653A1
Cited
WO1993011120A1
Cited
EP0551182A1
Cited
US5423885A
Cited
US5755769A
Cited
US5591227A
Cited
US5443496A
Cited
US5282823A
Cited
US5697967A
Cited
EP0568310A1
Cited
EP0567816A1
Cited
US5383928A
Cited
US5578075A
Cited
US5449382A
Cited
US5578075B1
Cited
EP0604022A1
Cited
US5443458A
Cited
US5419760A
Cited
US5733925A
Cited
WO1994021308A1
Cited
US5562922A
Cited
US5464650A
Cited
US5837008A
Cited
EP0623354A1
Cited
US5776184A
Cited
US5624411A
Cited
US5679400A
Cited
EP0706376B1
Cited
US5716981A
Cited
US5616608A
Cited
US5380299A
Cited
WO1996003092A1
Cited
WO1996003984A1
Cited
US5626862A
Cited
US5651986A
Cited
US5660873A
Cited
US5700286A
Cited
US5637113A
Cited
WO1996025176A1
Cited
US5674241A
Cited
WO1996026689A1
Cited
US5605696A
Cited
US5674242A
Cited
US5609629A
Cited
WO1998036784A1
Cited
US5779732A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-09-19 | 2004-03-20 | 2004-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-09-19 | 2008-03-20 | 2008-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-09-19 | 2012-03-20 | 2012-09-19 | $7700.00 | Window Closed / Lapsed |