US6053900A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apparatus and method for delivering diagnostic and therapeutic agents intravascularly
Assignee: Individual
•
Filing: 1998-10-07
•
Granted: 2000-04-25
•
Expires: 2018-10-07
Abstract
Abstract An apparatus and method for delivering diagnostic and therapeutic agents intravascularly in which the apparatus has a shape defined by a preset shape of a resilient fiber core. The resilient fiber core is covered by a soft polymer tubing or other polymer material to form a delivery apparatus that takes the shape of the resilient fiber core. Various shapes and structures are disclosed that infuse diagnostic and therapeutic agents through a lumen of the polymer tubing, that deliver the agents in the form of a soluble coating, and that circulate or contain a preloaded charge of radioactive material for intravascular radiotherapy. The resilient fiber core and soft polymer material permit the construction of a very small apparatus that can be removed easily following treatment. Various deployment systems are disclosed for deploying the delivery apparatuses into a vessel and for protecting against radiation exposure.
Inventors
- 👤 Joe E. Brown
- 👤 Matt D. Pursley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:49
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/0021; A61M25/0041; A61M25/0017; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/88; A61F2250/00; A61F2250/0058; A61F2250/0067; A61F2250/0096; A61F2250/0098; A61M25/0043; A61M2025/0057; A61M25/01; A61M25/0105; A61M25/0108; A61M25/06; A61M25/0662; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N2005/1019; A61N2005/1021
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
71 words
A coil apparatus for delivering diagnostic and therapeutic agents intravascularly, comprising: a resilient fiber core having a linear portion and a coiled portion; and a polymer tubing encasing the resilient fiber core and adapting to the shape of the resilient fiber core, said polymer tubing comprising a first portion encasing the linear portion of the resilient fiber core and a second portion encasing the coiled portion of the resilient fiber core.
Claim 2
Dependent Claim
71 words
A coil apparatus for delivering diagnostic and therapeutic agents intravascularly, comprising: a resilient fiber core having a linear portion and a coiled portion; and a polymer tubing encasing the resilient fiber core and adapting to the shape of the resilient fiber core, said polymer tubing comprising a first portion encasing the linear portion of the resilient fiber core and a second portion encasing the coiled portion of the resilient fiber core.
Claim 3
Dependent Claim
57 words
The coil apparatus according to claim 1, wherein said polymer tubing is constructed from a braided, stitched, or other porous material, and said first portion of the polymer tubing is consolidated, coated, or impregnated so as to be non-porous, while said second portion of the polymer tubing remains porous for releasing fluid-based agents from said coil apparatus.
Claim 4
Dependent Claim
21 words
The coil apparatus according to claim 1, wherein said coiled portion of the resilient fiber core is spiral-shaped in plan view.
Claim 5
Dependent Claim
31 words
The coil apparatus according to claim 1, wherein said coiled portion of the resilient fiber core has a helical shape tapering from a relatively large end to a relatively small end.
Claim 6
Dependent Claim
34 words
The coil apparatus according to claim 1, wherein said polymer tubing comprises at least two lumens extending along a length of said polymer tubing said resilient fiber core extending through one of said lumens.
Claim 7
Dependent Claim
49 words
The coil apparatus according to claim 1, further comprising an inner sheath secured to an inner diameter of said second portion of said polymer tubing, said inner sheath having a passage extending therethrough to permit fluids to continue flowing through a vessel in which the coil apparatus is deployed.
Claim 8
Dependent Claim
30 words
The coil apparatus according to claim 1, wherein at least a portion of an outer surface of said polymer tubing is covered by a soluble coating containing a therapeutic agent.
Claim 9
Dependent Claim
51 words
The coil apparatus according to claim 1, wherein a first portion of said polymer tubing has an outer surface covered by a soluble coating containing a therapeutic agent and a second portion of said polymer tubing has a releasing means for releasing fluid-based agents from a lumen of the polymer tubing.
Claim 10
Dependent Claim
28 words
The coil apparatus according to claim 1, wherein said polymer tubing is provided with a return passage for circulating a suspension of radioactive material through a lumen thereof.
Claim 11
Dependent Claim
66 words
The coil apparatus according to claim 1, wherein said polymer tubing is provided with a double lumen construction with first and second lumens having distal ends connected together, said first lumen providing a supply passage to the coiled portion and said second lumen providing a return passage from the coiled portion for circulating a suspension of radioactive material through said coil apparatus to provide intravascular radiotherapy.
Claim 12
Dependent Claim
39 words
The coil apparatus according to claim 1, wherein said polymer tubing has a single lumen that supplies a fluid to a first end of the coiled portion and returns a fluid from a second end of the coiled portion.
Claim 13
Dependent Claim
20 words
The coil apparatus according to claim 1, further comprising a radioactive material loaded into a lumen of said polymer tubing.
Claim 14
Dependent Claim
38 words
The coil apparatus according to claim 1, wherein said polymer tubing comprises at least two lumens, said resilient fiber core extending through one of said lumens and a radioactive material being loaded into another one of said lumens.
Claim 15
Dependent Claim
26 words
The coil apparatus according to claim 1, further comprising a vent tube extending through a lumen of said polymer tubing for passing gas or fluid therethrough.
Claim 16
Dependent Claim
34 words
The coil apparatus according to claim 1, further comprising a guide tube attached to said first portion of the polymer tubing tor guiding said coil apparatus along a guide wire placed within a vessel.
Claim 17
Dependent Claim
62 words
The coil apparatus according to claim 1, further comprising an inner support tube attached to a first end of said coil and an outer support tube attached to a second end of said coil, said inner and outer support tubes being concentric and movable relative to each other to change at least one of a length and diameter of the coiled portion.
Claim 18
Independent Claim
67 words
A method for delivering diagnostic and therapeutic agents intravascularly, comprising the steps of: providing a coil apparatus having a resilient fiber core with a preset coiled portion, and a soft polymer tubing encasing the resilient fiber core and adapting to the shape of the resilient fiber core; placing said coil apparatus into a vessel; and causing a diameter of said coil apparatus to enlarge within the vessel.
Claim 19
Independent Claim
67 words
A method for delivering diagnostic and therapeutic agents intravascularly, comprising the steps of: providing a coil apparatus having a resilient fiber core with a preset coiled portion, and a soft polymer tubing encasing the resilient fiber core and adapting to the shape of the resilient fiber core; placing said coil apparatus into a vessel; and causing a diameter of said coil apparatus to enlarge within the vessel.
Claim 20
Dependent Claim
76 words
The method according to claim 17, further comprising the steps of: loading said coil apparatus into a delivery sheath having an internal diameter smaller than a preset diameter of the coiled portion of said resilient fiber core; inserting said delivery sheath and said coil apparatus into a vessel; and moving said coil apparatus out of said delivery sheath whereby said resilient fiber core causes said coil apparatus to increase in diameter and lodge within the vessel.
Claim 21
Dependent Claim
41 words
The method according to claim 17, further comprising the step of introducing a pressure into a lumen of the polymer tubing sufficient to cause a coiled portion of the coil-shaped apparatus to partially unwind and increase in diameter within the vessel.
Claim 22
Dependent Claim
27 words
The method according to claim 19. wherein said step of introducing a pressure comprises introducing a therapeutic agent into the lumen of the polymer tubing under pressure.
Claim 23
Dependent Claim
47 words
The method according to claim 17, wherein the coil-shaped apparatus has a guide tube fixed to a linear portion of the coil apparatus, and further comprising the step of causing the coiled portion of the apparatus to partially unwind and increase in diameter around the guide tube.
Claim 24
Dependent Claim
62 words
The method according to claim 17, further comprising the step of preparing the soft polymer tubing from a braided, stitched, or other porous material by consolidating, coatings or impregnating a first portion of the polymer tubing so as to make said first portion non-porous, while a second portion of the polymer tubing remains porous for releasing fluid-based agents from the coil apparatus.
Claim 25
Dependent Claim
105 words
The method according to claim 17, wherein the step of providing a coil apparatus comprises providing a coil-shaped apparatus having a coiled portion having first and second ends, said first end being connected to an inner support tube and said second end being connected to an outer support tube, said inner and outer support tubes being concentric and movable relative to each other in a telescoping manner; and further comprising the step of moving said inner and outer support tubes relative to each other to change at least one of a length and diameter of the coiled portion of the coil-shaped apparatus within the vessel.
Claim 26
Independent Claim
55 words
An apparatus for delivering diagnostic and therapeutic agents intravascularly, comprising: a resilient fiber core having a preset shape; and a polymer material covering the resilient fiber core and having a shape defined by the preset shape of the resilient fiber core said polymer material defining a space for containing an agent to be delivered intravascularly.
Claim 27
Independent Claim
55 words
An apparatus for delivering diagnostic and therapeutic agents intravascularly, comprising: a resilient fiber core having a preset shape; and a polymer material covering the resilient fiber core and having a shape defined by the preset shape of the resilient fiber core said polymer material defining a space for containing an agent to be delivered intravascularly.
Claim 28
Dependent Claim
50 words
The apparatus according to claim 24, wherein said preset shape of said resilient fiber core is such that said resilient fiber core defines a general outline of a cylindrical shape with an open central passage to permit fluids to continue flowing through a vessel in which the apparatus is deployed.
Claim 29
Dependent Claim
20 words
The apparatus according to claim 24, further comprising a radioactive material contained within said space defined by said polymer material.
Claim 30
Dependent Claim
41 words
The apparatus according to claim 24, wherein said preset shape of the resilient fiber core includes first and second circular segments connected by a linear segment, and said polymer material covers the circular and linear segments to define a cylindrical-shaped flap.
Claim 31
Dependent Claim
47 words
The apparatus according to claim 24, wherein said preset shape of the resilient fiber core includes a plurality of circular segments connected by a plurality of linear segments, and said polymer material covers the circular segments and the linear segments to define a plurality of cylindrical-shaped flaps.
Claim 32
Dependent Claim
43 words
The apparatus according to claim 24, wherein said preset shape of the resilient fiber core includes a plurality of circular segments, and said polymer material comprises a plurality of polymer tubing segments covering said circular segments to define a plurality of ring portions.
Claim 33
Dependent Claim
62 words
The apparatus according to claim 24, wherein said preset shape of the resilient fiber core includes a linear portion and a folded end portion, and said folded end portion comprises a plurality of folded segments extending generally parallel to the linear portion said folded segments being formed into a general outline of a cylindrical shape and being covered by a polymer tubing.
Claim 34
Dependent Claim
70 words
In combination, a delivery apparatus for delivering diagnostic and therapeutic agents intravascularly and an deployment apparatus for deploying the delivery apparatus, the delivery apparatus comprising: a resilient fiber core having a preset shape; and a polymer material covering the resilient fiber core and having a shape defined by the preset shape of the resilient fiber core, said polymer material defining a space for containing an agent to be delivered intravascularly.
Claim 35
Dependent Claim
70 words
In combination, a delivery apparatus for delivering diagnostic and therapeutic agents intravascularly and an deployment apparatus for deploying the delivery apparatus, the delivery apparatus comprising: a resilient fiber core having a preset shape; and a polymer material covering the resilient fiber core and having a shape defined by the preset shape of the resilient fiber core, said polymer material defining a space for containing an agent to be delivered intravascularly.
Claim 36
Dependent Claim
43 words
The combination of claim 31, wherein the delivery apparatus contains a radioactive material and the deployment apparatus comprises a deployment sheath formed of a material that blocks radiation emitted from said radioactive material when the delivery apparatus is placed within the deployment sheath.
Claim 37
Dependent Claim
46 words
The combination of claim 32, wherein the deployment apparatus further comprises a protective container through which said deployment sheath passes, said protective container being formed of a material that blocks radiation emitted from said radioactive material when the delivery apparatus is located within said protective container.
References Cited (Backward Citations)
US4655771B1
Cited
US4655771A
Cited
US4531933A
Cited
US4531943A
Cited
US4694838A
Cited
US4687482A
Cited
US4681570A
Cited
US4887996A
Cited
US4813925A
Cited
US5232444A
Cited
US5087244A
Cited
EP0399712A1
Cited
US5059166A
Cited
US5267960A
Cited
US5282785A
Cited
US5304121A
Cited
US5163928A
Cited
US5320604A
Cited
US5318531A
Cited
EP0526102A1
Cited
US5302168A
Cited
US5254089A
Cited
EP0567788A1
Cited
US5306250A
Cited
US5295962A
Cited
US5421826A
Cited
US5368566A
Cited
US5383928A
Cited
US5342301A
Cited
US5269755A
Cited
US5380307A
Cited
US5336178A
Cited
US5419760A
Cited
US5415637A
Cited
US5649958A
Cited
US5662580A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-04-25 | 2003-10-25 | 2004-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-04-25 | 2007-10-25 | 2008-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-04-25 | 2011-10-25 | 2012-04-25 | $7700.00 | Window Closed / Lapsed |