Patent US6031148A successfully refreshed from Google Patents.
US6031148A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implantable bioabsorbable article
Assignee: W.L. Gore and Associates Inc
•
Filing: 1993-04-02
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Granted: 2000-02-29
•
Expires: 2013-04-02
Abstract
Abstract An implantable bioabsorbable article for the separation and regeneration of tissue at a tissue defect site in the form of a fibrous matrix laminarly affixed to both surfaces of a cell-barrier sheet material. When implanted it allows ingrowth of tissue into the fibrous matrix side of the material; simultaneously the tissue to be regenerated at the tissue defect site is separated from the ingrowing tissue by the cell-barrier sheet material. A method for making the implantable bioabsorbable article is also described.
Inventors
- 👤 Byron Kent Hayes
- 👤 William R. Hardwick
- 👤 Charles F. White
- 👤 Mark D. Butler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:24
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/148; A61C; A61C8/00; A61C8/0003; A61C8/0004; A61C8/0006; A61F; A61F2/00; A61F2/0063; A61F2/0077; A61F2/02; A61F2/04; A61F2/06; A61F2/28; A61F2/2846; A61K; A61K6/00; A61K6/50; A61L27/00; A61L27/14; A61L27/18; A61L27/28; A61L27/34; A61L27/50; A61L27/58; A61L31/04; A61L31/06; A61L31/08; A61L31/10; A61B; A61B17/00; A61B17/04; A61B17/06; A61B17/06166; A61B2017/00004; A61B90/00; A61B90/08; A61B2090/0815; A61B2090/0816; A61F2/30; A61F2/3094; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30032; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30235; A61F2002/30667; A61F2002/30677; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0063; A61F2230/0069; A61F2240/00; A61F2240/001; A61F2250/00; A61F2250/0014; A61F2250/003; A61F2250/0058; A61F2250/0067
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
128 words
A bioabsorbable article useful for the separation and regeneration of tissue comprising: a) a bioabsorbable, pliable, not brittle, cell-barrier polymeric sheet material being defined by a length, a width, and a thickness wherein the thickness has the smallest dimension, and wherein surfaces bounded by the length and width define first and second opposing surfaces, said first and second opposing surfaces being separated by the thickness of the sheet material; b) a bioabsorbable fibrous matrix laminarly affixed to the first opposing surface of said bioabsorbable cell-barrier sheet material to cover at least a portion of the first opposing surface; and c) a bioabsorbable fibrous matrix laminarly affixed to the second opposing surface of said bioabsorbable cell-barrier sheet material to cover at least a portion of the second opposing surface.
Claim 2
Dependent Claim
128 words
A bioabsorbable article useful for the separation and regeneration of tissue comprising: a) a bioabsorbable, pliable, not brittle, cell-barrier polymeric sheet material being defined by a length, a width, and a thickness wherein the thickness has the smallest dimension, and wherein surfaces bounded by the length and width define first and second opposing surfaces, said first and second opposing surfaces being separated by the thickness of the sheet material; b) a bioabsorbable fibrous matrix laminarly affixed to the first opposing surface of said bioabsorbable cell-barrier sheet material to cover at least a portion of the first opposing surface; and c) a bioabsorbable fibrous matrix laminarly affixed to the second opposing surface of said bioabsorbable cell-barrier sheet material to cover at least a portion of the second opposing surface.
Claim 3
Dependent Claim
39 words
The article of claim 1 wherein both the cell-barrier sheet material and the fibrous matrix are comprised of a synthetic bioabsorbable material selected from the group consisting of polylactic acid, polyglycolic acid, poly-P-dioxanone, trimethylene carbonate, polycaprolactone and copolymers thereof.
Claim 4
Dependent Claim
26 words
The article of claim 2 wherein both the cell-barrier sheet material and the fibrous matrix are comprised of a copolymer of polylactic acid and polyglycolic acid.
Claim 5
Dependent Claim
31 words
The article of claim 2 wherein the cell-barrier sheet material is comprised of a copolymer of polylactic acid and polyglycolic acid and the fibrous matrix is comprised of polyglycolic acid fibers.
Claim 6
Dependent Claim
24 words
The article of claim 4 wherein the cell-barrier sheet material is comprised of a copolymer of about 50% polylactic acid and 50% polyglycolic acid.
Claim 7
Dependent Claim
24 words
The article of claim 4 wherein the cell-barrier sheet material is comprised of a copolymer of about 65% polylactic acid and 35% polyglycolic acid.
Claim 8
Dependent Claim
24 words
The article of claim 4 wherein the cell-barrier sheet material is comprised of a copolymer of about 85% polylactic acid and 15% polyglycolic acid.
Claim 9
Dependent Claim
19 words
The article of claim 1 wherein the fibrous matrix comprises a mesh of fibers in a random, unorganized configuration.
Claim 10
Dependent Claim
33 words
The article of claim 1 wherein the bioabsorbable fibrous matrix comprises a mesh of fibers in an organized configuration selected from the group consisting of threads, yarns, nets, knits, weaves, laces and felts.
Claim 11
Dependent Claim
27 words
The article of claim 1 wherein the cell-barrier sheet material is porous having a pore size small enough to substantially preclude the passage and ingrowth of tissue.
Claim 12
Dependent Claim
13 words
The article of claim 1 incorporating a suture affixed to the bioabsorbable article.
Claim 13
Dependent Claim
34 words
The article of claim 1 wherein at least a portion of the article is impregnated with a substance selected from the group consisting of antibiotics, antimicrobials, growth factors, differentiation factors and cell attachment factors.
Claim 14
Dependent Claim
91 words
A bioabsorbable article for promoting tissue regeneration, comprising a length of pliable, not brittle, bioabsorbable material having a first outer surface adapted for supporting tissue ingrowth, a second outer surface opposed to the first outer surface and adapted for supporting tissue ingrowth, the first and second outer surfaces each extending substantially the length of the bioabsorbable material, and a polymeric barrier between the first and second surfaces and extending substantially the length of the bioabsorbable material, the barrier adapted to substantially prevent tissue migration between the first and second outer surfaces.
Claim 15
Dependent Claim
91 words
A bioabsorbable article for promoting tissue regeneration, comprising a length of pliable, not brittle, bioabsorbable material having a first outer surface adapted for supporting tissue ingrowth, a second outer surface opposed to the first outer surface and adapted for supporting tissue ingrowth, the first and second outer surfaces each extending substantially the length of the bioabsorbable material, and a polymeric barrier between the first and second surfaces and extending substantially the length of the bioabsorbable material, the barrier adapted to substantially prevent tissue migration between the first and second outer surfaces.
Claim 16
Dependent Claim
16 words
The article of claim 13, wherein the length of bioabsorbable material is substantially planar in shape.
Claim 17
Dependent Claim
16 words
The article of claim 13, further comprising a suture attached to the length of bioabsorbable material.
Claim 18
Dependent Claim
98 words
A multi-layered bioabsorbable article for promoting tissue regeneration, comprising a pliable, not brittle, substantially cell-impermeable polymeric inner layer defined by a length, a width, and a thickness wherein the thickness has the smallest dimension, and wherein surfaces bounded by the length and width define first and second opposing surfaces, a first cell-permeable outer layer superposed on a first surface of the inner layer, and a second cell-permeable outer layer superposed on a second surface of the inner layer opposite the first surface so that the inner layer is positioned between and separates the first and second outer layers.
Claim 19
Dependent Claim
98 words
A multi-layered bioabsorbable article for promoting tissue regeneration, comprising a pliable, not brittle, substantially cell-impermeable polymeric inner layer defined by a length, a width, and a thickness wherein the thickness has the smallest dimension, and wherein surfaces bounded by the length and width define first and second opposing surfaces, a first cell-permeable outer layer superposed on a first surface of the inner layer, and a second cell-permeable outer layer superposed on a second surface of the inner layer opposite the first surface so that the inner layer is positioned between and separates the first and second outer layers.
Claim 20
Dependent Claim
13 words
The article of claim 16, wherein the article is substantially planar in shape.
Claim 21
Dependent Claim
13 words
The article of claim 16, further comprising a suture attached to the article.
Claim 22
Dependent Claim
142 words
A bioabsorbable article useful for the separation and regeneration of tissue comprising: a) a bioabsorbable, pliable, not brittle, cell-barrier sheet material being defined by a length, a width, and a thickness wherein the thickness has the smallest dimension, and wherein surfaces bounded by the length and width define first and second opposing surfaces, said first opposing surface being in a first plane and said second opposing surface being in a second plane, said planes being separated by the thickness of the sheet material; b) a bioabsorbable fibrous matrix laminarly affixed to the first opposing surface of said bioabsorbable cell-barrier sheet material to cover at least a portion of the first opposing surface; and c) a bioabsorbable fibrous matrix laminarly affixed to the second opposing surface of said bioabsorbable cell-barrier sheet material to cover at least a portion of the second opposing surface.
Claim 23
Dependent Claim
142 words
A bioabsorbable article useful for the separation and regeneration of tissue comprising: a) a bioabsorbable, pliable, not brittle, cell-barrier sheet material being defined by a length, a width, and a thickness wherein the thickness has the smallest dimension, and wherein surfaces bounded by the length and width define first and second opposing surfaces, said first opposing surface being in a first plane and said second opposing surface being in a second plane, said planes being separated by the thickness of the sheet material; b) a bioabsorbable fibrous matrix laminarly affixed to the first opposing surface of said bioabsorbable cell-barrier sheet material to cover at least a portion of the first opposing surface; and c) a bioabsorbable fibrous matrix laminarly affixed to the second opposing surface of said bioabsorbable cell-barrier sheet material to cover at least a portion of the second opposing surface.
Claim 24
Dependent Claim
91 words
A bioabsorbable article for promoting tissue regeneration, comprising a length of pliable, not brittle, bioabsorbable material having a first outer surface adapted for supporting tissue ingrowth, a second outer surface opposed to the first outer surface and adapted for supporting tissue ingrowth, the first and second outer surfaces each extending substantially the length of the bioabsorbable material, and a cell barrier between the first and second surfaces and extending substantially the length of the bioabsorbable material, the barrier adapted to substantially prevent tissue migration between the first and second outer surfaces.
Claim 25
Dependent Claim
91 words
A bioabsorbable article for promoting tissue regeneration, comprising a length of pliable, not brittle, bioabsorbable material having a first outer surface adapted for supporting tissue ingrowth, a second outer surface opposed to the first outer surface and adapted for supporting tissue ingrowth, the first and second outer surfaces each extending substantially the length of the bioabsorbable material, and a cell barrier between the first and second surfaces and extending substantially the length of the bioabsorbable material, the barrier adapted to substantially prevent tissue migration between the first and second outer surfaces.
Claim 26
Dependent Claim
97 words
A multi-layered bioabsorbable article for promoting tissue regeneration, comprising a pliable, not brittle, substantially cell-impermeable inner layer defined by a length, a width, and a thickness wherein the thickness has the smallest dimension, and wherein surfaces bounded by the length and width define first and second opposing surfaces, a first cell-permeable outer layer superposed on a first surface of the inner layer, and a second cell-permeable outer layer superposed on a second surface of the inner layer opposite the first surface so that the inner layer is positioned between and separates the first and second outer layers.
Claim 27
Dependent Claim
97 words
A multi-layered bioabsorbable article for promoting tissue regeneration, comprising a pliable, not brittle, substantially cell-impermeable inner layer defined by a length, a width, and a thickness wherein the thickness has the smallest dimension, and wherein surfaces bounded by the length and width define first and second opposing surfaces, a first cell-permeable outer layer superposed on a first surface of the inner layer, and a second cell-permeable outer layer superposed on a second surface of the inner layer opposite the first surface so that the inner layer is positioned between and separates the first and second outer layers.
References Cited (Backward Citations)
FR560934A
Cited
US2748781A
Cited
US2991224A
Cited
US3386440A
Cited
FR1499912A
Cited
US3589011A
Cited
US3953566A
Cited
US4187390A
Cited
US3855638A
Cited
US3754332A
Cited
GB1390445A
Cited
US3863344A
Cited
US3879767A
Cited
US3909852A
Cited
US4039653A
Cited
US4136162A
Cited
US3971670A
Cited
US4020558A
Cited
US3971134A
Cited
FR2306672A1
Cited
US4007494A
Cited
GB1602932A
Cited
US4175326A
Cited
US4244689A
Cited
US4303712A
Cited
US4195405A
Cited
US4252525A
Cited
US4321914A
Cited
US4400833A
Cited
EP0089782A1
Cited
US4520821A
Cited
US4492577A
Cited
US4534349A
Cited
US4883618A
Cited
US4664474A
Cited
US4643734A
Cited
US4531916A
Cited
US4655777A
Cited
US4841962A
Cited
US4886870A
Cited
EP0171173A1
Cited
WO1986000517A1
Cited
US5032445A
Cited
GB2161080A
Cited
US4752294A
Cited
US4595713A
Cited
US4923470A
Cited
US5061281A
Cited
US4743252A
Cited
US5084051A
Cited
EP0274898A2
Cited
WO1988005312A1
Cited
EP0303496A1
Cited
US4916193A
Cited
US4961707A
Cited
US4870966A
Cited
WO1990000410A1
Cited
WO1990001824A1
Cited
US5010009A
Cited
GB2222954A
Cited
DE3830481A1
Cited
FR2635966A1
Cited
EP0359575A2
Cited
US5024671A
Cited
US5011486A
Cited
EP0370292A1
Cited
WO1990007308A1
Cited
WO1990011730A1
Cited
WO1990013302A1
Cited
US5077049A
Cited
US5676699A
Cited
US5651505A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-02-28 | 2003-08-30 | 2004-02-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-02-28 | 2007-08-30 | 2008-02-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-02-28 | 2011-08-30 | 2012-02-29 | $7700.00 | Window Closed / Lapsed |