Patent US6028311A successfully refreshed from Google Patents.
US6028311A
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Rapid non-invasive optical analysis using broad bandpass spectral processing
Assignee: Optix LP
•
Filing: 1998-08-21
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Granted: 2000-02-22
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Expires: 2018-08-21
Abstract
Abstract The present invention provides a generally applicable apparatus and method for achieving measurements of a constituent in a sample. This is achieved by employing a detection means having a plurality of detectors responsive to radiation in a selected region of the spectrum, e.g., the infrared. In most embodiments, at least two of the detectors provide broad wavelength bandpass. If narrow bandpass sources or detectors are used, the information generated is processed in a manner similar to broadband information. The broad bandpass response of the detectors can be contrasted with the approach of classical spectrophotometry, in which the spectral response of the detectors is designed to be as narrow as feasible, and substantially narrower than the spectral features of the constituent or constituents of interest. The data is processed such that the contributions of known background constituents and scattering is eliminated prior to further processing, thereby yielding a better result in high background situations. The use of intensity processing rather than absorbance processing also allows the method and apparatus to be used in a variety of non-ideal situations.
Inventors
- 👤 Lester Sodickson
- 👤 Howard E. Guthermann
- 👤 Myron J. Block
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:55
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/47; G01N21/4795; A; A61; A61B; A61B5/00; A61B5/0059; A61B5/145; A61B5/14532; A61B5/14546; A61B5/1455; A61B5/68; A61B5/6801; A61B5/6813; A61B5/6825; A61B5/6826; A61B5/683; A61B5/6838; G01N21/25; G01N21/31; G01N21/35; G01N21/359; G01N2021/3129; G01N2021/3137
Claims Analysis
Total Claims: 68
Claim 1
Independent Claim
231 words
An apparatus for determining the concentration of a constituent of interest in a sample which has transmittance, emittance, or reflectance in a selected region of the spectrum comprising: illumination means which generates a plurality of beams of illuminating radiation in a selected region of the spectrum; coding means for placing an identifiable, distinct code on each of said plurality of beams of radiation; means for individually limiting the wavelength of each of said plurality of beams such that each beam is limited in wavelength to a distinct portion of said selected region of said spectrum, whereby at least one of said beams covers a broadband spectral region; transmission means for transmitting said coded beams to illuminate said sample; detection means for detecting the intensity of radiation transmitted, emitted, or reflected by said sample, said detection means including at least one broad band detector and decoding means for identifying the code on each of said coded beams, said detection means generating output signals which are functions of the information carried by each coded beam; and analysis means for converting said output signals into a measure of said concentration of said constituent of interest in said sample; wherein said analysis means generates a response which is an analog of a location in an n-dimensional colorimetric space, where n is equal to, or less than, the number of beams used to illuminate said sample.
Claim 2
Independent Claim
231 words
An apparatus for determining the concentration of a constituent of interest in a sample which has transmittance, emittance, or reflectance in a selected region of the spectrum comprising: illumination means which generates a plurality of beams of illuminating radiation in a selected region of the spectrum; coding means for placing an identifiable, distinct code on each of said plurality of beams of radiation; means for individually limiting the wavelength of each of said plurality of beams such that each beam is limited in wavelength to a distinct portion of said selected region of said spectrum, whereby at least one of said beams covers a broadband spectral region; transmission means for transmitting said coded beams to illuminate said sample; detection means for detecting the intensity of radiation transmitted, emitted, or reflected by said sample, said detection means including at least one broad band detector and decoding means for identifying the code on each of said coded beams, said detection means generating output signals which are functions of the information carried by each coded beam; and analysis means for converting said output signals into a measure of said concentration of said constituent of interest in said sample; wherein said analysis means generates a response which is an analog of a location in an n-dimensional colorimetric space, where n is equal to, or less than, the number of beams used to illuminate said sample.
Claim 3
Dependent Claim
16 words
The apparatus of claim 1 wherein at least two of said beams comprise overlapping broadband beams.
Claim 4
Dependent Claim
16 words
The apparatus of claim 1 wherein at least two of said beams comprise non-overlapping broadband beams.
Claim 5
Dependent Claim
16 words
The apparatus of claim 1 wherein said illuminating radiation comprises infrared radiation between about 700-2500 nm.
Claim 6
Dependent Claim
29 words
The apparatus of claim 1 wherein said illumination means comprises a radiation source and beam splitters which splits radiation generated by said radiation source into said plurality of beams.
Claim 7
Dependent Claim
16 words
The apparatus of claim 1 wherein said illumination means comprises a plurality of separate radiation sources.
Claim 8
Dependent Claim
13 words
The apparatus of claim 1 wherein said analysis means comprises a neural network.
Claim 9
Dependent Claim
39 words
The apparatus of claim 1 wherein said means for limiting the wavelength comprises a plurality of broad bandpass filters, each of said filters having a spectral transmission substantially limited to a distinct portion of the spectrum of illuminating radiation.
Claim 10
Dependent Claim
17 words
The apparatus of claim 1 wherein said coding means individually temporally modulates the intensity of said beams.
Claim 11
Dependent Claim
18 words
The apparatus of claim 9 wherein said coding means comprises a chopper associated with each of said beams.
Claim 12
Dependent Claim
15 words
The apparatus of claim 1 wherein said sample comprises a portion of an animal body.
Claim 13
Dependent Claim
13 words
The apparatus of claim 11 where said animal body is a human body.
Claim 14
Dependent Claim
16 words
The apparatus of claim 12 wherein said constituent of interest is an analyte of clinical interest.
Claim 15
Dependent Claim
40 words
The apparatus of claim 13 wherein said analyte of clinical interest is selected from the group consisting of glucose, glucose indicating constituents, drugs of abuse, drugs of abuse indicating constituents, alcohol, proteins, lipoproteins, hemoglobin and its variants, cholesterol, and lipids.
Claim 16
Dependent Claim
22 words
The apparatus of claim 1 wherein apparatus is arranged such that said plurality of separate beams provide congruent illumination of said sample.
Claim 17
Dependent Claim
33 words
The apparatus of claim 15 further comprising a plurality of detectors in said detection means and beam splitter means to direct the radiation reflected, emitted, or transmitted from said sample to said detectors.
Claim 18
Dependent Claim
59 words
The apparatus of claim 1 wherein said transmission means comprises a plurality of optical fibers, one end of each of said optical fibers admitting radiation from one of said beams, the other ends of said optical fibers being randomly distributed in a fiber bundle so as to provide substantially uniform distribution of said beams and illumination of said sample.
Claim 19
Dependent Claim
15 words
The apparatus of claim 17 wherein said optical fibers are arranged to provide congruent illumination.
Claim 20
Dependent Claim
29 words
The apparatus of claim 18 comprising at least a first detection means and a second detection means, each of said detection means having a distinct set of detectors therein.
Claim 21
Dependent Claim
22 words
The apparatus of claim 19 wherein at least one of said first and second detection means is arranged to provide incongruent measurement.
Claim 22
Dependent Claim
63 words
The apparatus of claim 19 wherein said analysis means comprises means to compare output signals generated from data from each of said detection means to generate a response indicative of the concentration of said constituent of interest while rendering the interfering features of the backgrounds from each of said detection means to be less distinct than if only one detection means was used.
Claim 23
Dependent Claim
26 words
The apparatus of claim 19 wherein said first detection means and said second detection means are arranged to obtain radiation from different portions of said sample.
Claim 24
Dependent Claim
18 words
The apparatus of claim 19 wherein said first and second detection means are arranged to provide congruent sampling.
Claim 25
Dependent Claim
26 words
The apparatus of claim 1 wherein said analysis means is arranged such that the outputs from said detectors are combined before any additional mathematical processing occurs.
Claim 26
Dependent Claim
18 words
The apparatus of claim 24 wherein said analysis means provides mathematical processing of intensity rather than absorbance values.
Claim 27
Dependent Claim
25 words
The apparatus of claim 1 wherein said analysis means comprises means to eliminate responses generated from known background components prior to any additional mathematical processing.
Claim 28
Dependent Claim
23 words
The apparatus of claim 1 wherein said apparatus comprises interrogation means which collects outputs from said detectors for all illumination beams substantially simultaneously.
Claim 29
Dependent Claim
39 words
The apparatus of claim 27 wherein said interrogation means collects outputs from said detectors in a sufficiently rapid manner to observe a distinct arterial pulse wave form so as to allow differentiation of constituents of interest in arterial blood.
Claim 30
Dependent Claim
23 words
The apparatus of claim 1 wherein said detectors are located such that they obtain radiation from said sample only within restricted solid angles.
Claim 31
Dependent Claim
28 words
The apparatus of claim 1 wherein at least a portion of said illuminating radiation is directed through a reference material to an additional detector to generate reference values.
Claim 32
Dependent Claim
22 words
The apparatus of claim 1 wherein said decoding means comprises electrical narrow bandpass filters substantially centered about the temporal frequency of modulation.
Claim 33
Dependent Claim
42 words
The apparatus of claim 1 wherein at least one of said detectors is formed, at least in part, from a material selected from the group consisting of silicon photocells, lead selenide cells, indium gallium arsenide cells, germanium cells, and lead sulfide cells.
Claim 34
Dependent Claim
32 words
The apparatus of claim 1 wherein said detection means further comprises a separate black/white luminosity detector which is responsive to and overlaps said spectral response of all of said plurality of detectors.
Claim 35
Independent Claim
221 words
A method for determining the concentration of a constituent of interest in a sample which has transmittance, emittance, or reflectance in a selected region of the spectrum comprising: coding each of a plurality of beams of illuminating radiation by placing an identifiable, distinct code thereon; individually optically filtering each of said plurality of beams such that each beam is limited to a distinct portion of said selected region of said spectrum; transmitting said coded beams to illuminate said sample; detecting the intensity of radiation transmitted, emitted, or reflected by said sample; decoding the code on each of said coded beams to generate an output signal which is a function of the information carried by each coded beam; generating a processing input signal which is responsive to selected aspects of the background of the detection system and the sample, and said constituent of interest utilizing the output signal generated from a coded beam from a broadband source, and analyzing said output signals and said processing input signal with an analysis means to generate a measure of said concentration of said constituent of interest in said sample; wherein said analysis means generates a response which is an analog of a location in an n-dimensional colorimetric space, where n is equal to, or less than, the number of beams used to illuminate said sample.
Claim 36
Independent Claim
221 words
A method for determining the concentration of a constituent of interest in a sample which has transmittance, emittance, or reflectance in a selected region of the spectrum comprising: coding each of a plurality of beams of illuminating radiation by placing an identifiable, distinct code thereon; individually optically filtering each of said plurality of beams such that each beam is limited to a distinct portion of said selected region of said spectrum; transmitting said coded beams to illuminate said sample; detecting the intensity of radiation transmitted, emitted, or reflected by said sample; decoding the code on each of said coded beams to generate an output signal which is a function of the information carried by each coded beam; generating a processing input signal which is responsive to selected aspects of the background of the detection system and the sample, and said constituent of interest utilizing the output signal generated from a coded beam from a broadband source, and analyzing said output signals and said processing input signal with an analysis means to generate a measure of said concentration of said constituent of interest in said sample; wherein said analysis means generates a response which is an analog of a location in an n-dimensional colorimetric space, where n is equal to, or less than, the number of beams used to illuminate said sample.
Claim 37
Dependent Claim
16 words
The methods of claim 34 wherein said illuminating radiation comprises infrared radiation between about 700-2500 nm.
Claim 38
Dependent Claim
36 words
The method of claim 34 wherein said illumination step comprises illuminating said sample with an apparatus having a radiation source and beam splitters which split radiation generated by said radiation source into said plurality of beams.
Claim 39
Dependent Claim
23 words
The method of claim 34 wherein said illumination step comprises illuminating said sample with beams generated from a plurality of separate radiation sources.
Claim 40
Dependent Claim
19 words
The method of claim 34 wherein said analysis is carried out, at least in part, by a neural network.
Claim 41
Dependent Claim
43 words
The method of claim 34 wherein said optical filtering is carried out, at least in part, by a plurality of broad bandpass filters, each of said filters having a spectral transmission substantially limited to a distinct portion of the spectrum of illuminating radiation.
Claim 42
Dependent Claim
20 words
The method of claim 34 wherein said coding step is provided by individually temporally modulating the intensity of said beams.
Claim 43
Dependent Claim
20 words
The method of claim 40 wherein said coding step comprises modulation using a chopper associated with each of said beams.
Claim 44
Dependent Claim
15 words
The method of claim 34 wherein said sample comprises a portion of an animal body.
Claim 45
Dependent Claim
13 words
The method of claim 42 where said animal body is a human body.
Claim 46
Dependent Claim
16 words
The method of claim 43 wherein said constituent of interest is an analyte of clinical interest.
Claim 47
Dependent Claim
40 words
The method of claim 44 wherein said analyte of clinical interest is selected from the group consisting of glucose, glucose indicating constituents, drugs of abuse, drugs of abuse indicating constituents, alcohol, proteins, lipoproteins, hemoglobin and its variants, cholesterol, and lipids.
Claim 48
Dependent Claim
17 words
The method of claim 34 wherein said plurality of separate beams provide congruent illumination of said sample.
Claim 49
Dependent Claim
33 words
The method of claim 46 further comprising the step of directing the radiation reflected, emitted, or transmitted from said sample to a plurality of detectors in a detection means by a beam splitter.
Claim 50
Dependent Claim
63 words
The method of claim 34 wherein said beams are transmitted to said sample by a plurality of optical fibers, one end of each of said optical fibers admitting radiation from one of said beams, the other ends of said optical fibers being randomly distributed in a fiber bundle so as to provide substantially uniform distribution of said beams and illumination of said sample.
Claim 51
Dependent Claim
15 words
The method of claim 48 wherein said optical fibers are arranged to provide congruent illumination.
Claim 52
Dependent Claim
36 words
The method of claim 34 wherein said detecting step is carried out using at least a first detection means and a second detection means, each of said detection means having a distinct set of detectors therein.
Claim 53
Dependent Claim
26 words
The method of claim 50 wherein at least one of said first and second detection means is arranged to provide measurements that are not congruent measurements.
Claim 54
Dependent Claim
57 words
The method of claim 50 wherein said analysis step comprises comparing data generated from each of said detection means to generate information indicative of the concentration of said constituent of interest while rendering the interfering features of the backgrounds from each of said detection means to be less distinct than if a single detection means is used.
Claim 55
Dependent Claim
42 words
The method of claim 50 wherein said at least two distinct portions of said sample are illuminated and radiation therefrom is detected, said first detection means and said second detection means being arranged to obtain radiation from different portions of said sample.
Claim 56
Dependent Claim
20 words
The method of claim 50 wherein congruent sampling is achieved by geometric arrangement of said first and second detection means.
Claim 57
Dependent Claim
29 words
The method of claim 34 wherein said analysis step is carried out such that the data generated in said detection step is combined before any additional mathematical processing occurs.
Claim 58
Dependent Claim
19 words
The method of claim 55 wherein said analysis step acts by mathematical processing of intensity rather than absorbance values.
Claim 59
Dependent Claim
25 words
The method of claim 55 wherein said analysis step is used to eliminate data generated from known background components prior to any additional mathematical processing.
Claim 60
Dependent Claim
37 words
The method of claim 42 wherein said detection step comprises interrogating a detection means in a manner which is sufficiently rapid that the output signals from said detection means are collected substantially simultaneously for all illuminating beams.
Claim 61
Dependent Claim
37 words
The method of claim 58 wherein said interrogation step is carried out in a sufficiently rapid manner to observe a distinct arterial pulse wave form so as to allow differentiation of constituents of interest in arterial blood.
Claim 62
Dependent Claim
26 words
The method of claim 34 wherein said detecting step is carried out such that radiation is obtained from said sample only within a restricted solid angle.
Claim 63
Dependent Claim
36 words
The method of claim 34 wherein at least a portion of said illuminating radiation is directed through a reference material to a detector to generate reference values which can be used to correct for color constancy.
Claim 64
Dependent Claim
37 words
The method of claim 40 wherein said transmitting step includes transmitting said coded beam at a predetermined frequency and said decoding is achieved, at least in part, using electrical narrow bandpass filters substantially centered about said frequency.
Claim 65
Dependent Claim
16 words
The method of claim 34 wherein at least two of said beams have overlapping spectral characteristics.
Claim 66
Dependent Claim
24 words
The method of claim 34 wherein the outputs generated from a said broadband beam forms at least a part of said processing input signal.
Claim 67
Independent Claim
231 words
A method for determining the concentration of a constituent of interest in a sample which has transmittance, emittance, or reflectance in a selected region of the spectrum comprising: coding each of a plurality of beams of illuminating radiation by placing an identifiable, distinct code thereon; individually optically filtering each of said plurality of beams such that each beam is limited to a distinct portion of said selected region of said spectrum; transmitting said coded beams to illuminate said sample; detecting the intensity of radiation transmitted, emitted, or reflected by said sample; decoding the code on each of said coded beams to generate an output signal which is a function of the information carried by each coded beam; generating a processing input signal which is responsive to selected aspects of the background of the detection system and the sample, and said constituent of interest utilizing the output signal generated by combining the output signals generated from coded beams from some of said detectors to simulate broadband detection, and analyzing said output signals and said processing input signal with an analysis means to generate a measure of said concentration of said constituent of interest in said sample; wherein said analysis means generates a response which is an analog of a location in an n-dimensional colorimetric space, where n is equal to, or less than, the number of beams used to illuminate said sample.
Claim 68
Independent Claim
231 words
A method for determining the concentration of a constituent of interest in a sample which has transmittance, emittance, or reflectance in a selected region of the spectrum comprising: coding each of a plurality of beams of illuminating radiation by placing an identifiable, distinct code thereon; individually optically filtering each of said plurality of beams such that each beam is limited to a distinct portion of said selected region of said spectrum; transmitting said coded beams to illuminate said sample; detecting the intensity of radiation transmitted, emitted, or reflected by said sample; decoding the code on each of said coded beams to generate an output signal which is a function of the information carried by each coded beam; generating a processing input signal which is responsive to selected aspects of the background of the detection system and the sample, and said constituent of interest utilizing the output signal generated by combining the output signals generated from coded beams from some of said detectors to simulate broadband detection, and analyzing said output signals and said processing input signal with an analysis means to generate a measure of said concentration of said constituent of interest in said sample; wherein said analysis means generates a response which is an analog of a location in an n-dimensional colorimetric space, where n is equal to, or less than, the number of beams used to illuminate said sample.
References Cited (Backward Citations)
DE233873C
Cited
US4178917A
Cited
US4278538A
Cited
US4286327A
Cited
EP0030610B1
Cited
US4641973A
Cited
US4520265A
Cited
US4543481A
Cited
SU1187032A1
Cited
US4799795A
Cited
US4655225A
Cited
WO1988001128A2
Cited
US4805623A
Cited
US4883953A
Cited
US4882492A
Cited
US4850365A
Cited
US4928014A
Cited
US5028787A
Cited
US4975581A
Cited
US5070874A
Cited
US5054487A
Cited
US5321565A
Cited
US5210590A
Cited
US5321265A
Cited
US5424545A
Cited
US5433197A
Cited
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