EP0030610B1
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EP
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Method and device for quantitative determination of optically active substances
Assignee: Phillips Medisize AS
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Filing: 1980-10-27
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Granted: 1986-03-05
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Expires: 2000-10-27
Abstract
Abstract 1. A process for the quantitative determiantion of a dissolved optically active substance in aqueous or non-aqueous solutions by means of polarimetry by splitting the light beam after the sample by means of a beam splitter, thereby producing a measuring beam and a reference beam, and forming a difference or quotient signal of the signals of the measuring and the reference beam detected by corresponding detectors, whereby the polarized light of the light source prior to passing through of the sample is eventually subjected to frequency, phase, or amplitude modulation, and the difference or quotient signal formed of the signals of the measuring and the reference beam is demodulated correspondingly, characterized in that for simultaneously obtaining beam splitting and an analyzing effect the light beam after the sample is directed to an optical interface at an incidence angle (alpha) between the polarization angle and the limit angle of total reflection.
Inventors
- 👤 Arno Dr. Dipl.-Phys. Müller
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 16:20
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/14558; G; G01; G01N; G01N21/00; G01N21/17; G01N21/21
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
148 words
A process for the quantitative determination of a dissolved optically active substance in aqueous or non-aqueous solutions by means of.polarimetry by splitting the light beam after the sample by means of a beam splitter, thereby producing a measuring beam and a reference beam, and forming a difference or quotient signal of the signals of the measuring and the reference beam detected by corresponding detectors, whereby the polarized light of the light source prior to passing through of the sample is eventually subjected to frequency, phase, or amplitude modulation, and the difference or quotient signal formed of the signals of the measuring and the reference beam is demodulated correspondingly, characterized in that for simultaneously obtaining beam splitting and an analyzing effect the light beam after the sample is directed to an optical interface at an incidence angle (a) between the polarization angle and the limit angle of total reflection.
Claim 2
Dependent Claim
148 words
A process for the quantitative determination of a dissolved optically active substance in aqueous or non-aqueous solutions by means of.polarimetry by splitting the light beam after the sample by means of a beam splitter, thereby producing a measuring beam and a reference beam, and forming a difference or quotient signal of the signals of the measuring and the reference beam detected by corresponding detectors, whereby the polarized light of the light source prior to passing through of the sample is eventually subjected to frequency, phase, or amplitude modulation, and the difference or quotient signal formed of the signals of the measuring and the reference beam is demodulated correspondingly, characterized in that for simultaneously obtaining beam splitting and an analyzing effect the light beam after the sample is directed to an optical interface at an incidence angle (a) between the polarization angle and the limit angle of total reflection.
Claim 3
Dependent Claim
23 words
A process according to claim 1, characterized in that for obtaining beam splitting and an analyzing effect a plane parallel plate is used.
Claim 4
Dependent Claim
49 words
A process according to claim 1, characterized in that for obtaining beam splitting and an analyzing effect a prism is used and the beam reflected at the interface to the optically thinner medium and refracted at the second interface to the optically thinner medium is used as reflected beam.
Claim 5
Dependent Claim
41 words
A process according to claim 3, characterized in that a prism is used having such angles of the triangular cross section that the irradiated light is impacting on both interfaces in the direction of the thinner medium at the same angle.
Claim 6
Dependent Claim
27 words
A process according to claim 3 or 4, characterized in that a prism is used having the angles a, 2a, and (180-3a) of the triangular cross section.
Claim 7
Dependent Claim
103 words
A highly sensitive polarimeter comprising a light source (1) of polarized light, a sample part for taking-up a sample (3), a beam splitter (5), detectors (7, 7 * ) for the measuring and the reference beam, respectively, a differential amplifier or quotient former (8), a signal amplifier (15), and a display, output, or registering unit (10), characterized in that as beam splitter and analyzer as well a plane parallel plate (5) is arranged in such a way that the angle a of incidence measured towards the perpendicular on the reflecting surface is between the limit angle of total reflection and the polarization angle.
Claim 8
Dependent Claim
103 words
A highly sensitive polarimeter comprising a light source (1) of polarized light, a sample part for taking-up a sample (3), a beam splitter (5), detectors (7, 7 * ) for the measuring and the reference beam, respectively, a differential amplifier or quotient former (8), a signal amplifier (15), and a display, output, or registering unit (10), characterized in that as beam splitter and analyzer as well a plane parallel plate (5) is arranged in such a way that the angle a of incidence measured towards the perpendicular on the reflecting surface is between the limit angle of total reflection and the polarization angle.
Claim 9
Dependent Claim
123 words
A highly sensitive polarimeter comprising a light source (1) of polarized light a sample part for taking-up a sample (3), a beam splitter (5), detectors (7, 7 * ) for the measuring and the reference beam, respectively, a differential amplifier or quotient former (8), a signal amplifier (15), and a display, output, or registering unit (10), characterized in that as beam splitter and analyzer as well a prism (5) having the angles a, 2a, and (180-3a) of the triangle cross section is arranged in such a way that the angle a of incidence measured towards the perpendicular on the reflecting surface is equal to the angle a of the prism, a being between the limit angle of total reflection and the polarization angle.
Claim 10
Dependent Claim
123 words
A highly sensitive polarimeter comprising a light source (1) of polarized light a sample part for taking-up a sample (3), a beam splitter (5), detectors (7, 7 * ) for the measuring and the reference beam, respectively, a differential amplifier or quotient former (8), a signal amplifier (15), and a display, output, or registering unit (10), characterized in that as beam splitter and analyzer as well a prism (5) having the angles a, 2a, and (180-3a) of the triangle cross section is arranged in such a way that the angle a of incidence measured towards the perpendicular on the reflecting surface is equal to the angle a of the prism, a being between the limit angle of total reflection and the polarization angle.
Claim 11
Dependent Claim
34 words
A polarimeter according to claim 6 or 7,' characterized in that the optical part is miniaturized and designed to be fastened to an ear and to carry out the measuring at an earlobe, respectively.
Claim 12
Dependent Claim
50 words
A polarimeter according to any one of claims 6 to 8, characterized in that it is connected to a controlling and/or a dosing unit and controls said unit directly, said unit dosing a liquid, particularly insulin, into the body in dependence of the detected concentration of the optically active substance.
References Cited (Backward Citations)
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