US6005087A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2'-modified oligonucleotides
Assignee: Ionis Pharmaceuticals Inc
•
Filing: 1998-03-05
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Granted: 1999-12-21
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Expires: 2018-03-05
Abstract
Abstract Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
Inventors
- 👤 Phillip Dan Cook
- 👤 Andrew Mamoru Kawasaki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:41
CPC Classifications
C; C07; C07H; C07H21/00; C07H21/04; A; A61; A61K; A61K31/00; A61K31/70; A61K31/7088; A61K31/7125; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; C07H19/16; C07H19/20; C07H23/00; C07J; C07J43/00; C07J43/003; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/111; C12N15/113; C12N15/1137; C12N9/00; C12N9/0004; C12N9/0069; C12Q; C12Q1/00; C12Q1/68; C12Y; C12Y113/00; C12Y113/11; C12Y113/11012; A61K38/00; A61K48/00; C12N2310/00; C12N2310/10; C12N2310/11; C12N2310/30; C12N2310/31; C12N2310/312; C12N2310/3125; C12N2310/315; C12N2310/32; C12N2310/321; C12N2310/322; C12N2310/33; C12N2310/333; C12N2310/336; C12N2310/35; C12N2310/352; C12N2310/3521; C12N2310/3523; C12N2310/3527; C12N2310/353; C12N2310/3531; C12N2310/3533
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
78 words
A compound comprising a plurality of covalently-bound nucleosides that individually include a ribose or deoxyribose sugar portion and a base portion, wherein: said nucleosides are joined together by internucleoside linkages such that the base portion of said nucleosides form a mixed base sequence; at least one of said nucleosides includes a modified ribofuranosyl moiety bearing a 2'-fluoro substituent; provided that at least two of said nucleosides are 2-fluoro modified ribofuranosyl nucleosides when said internucleoside linkages are phosphodiester linkages.
Claim 2
Dependent Claim
78 words
A compound comprising a plurality of covalently-bound nucleosides that individually include a ribose or deoxyribose sugar portion and a base portion, wherein: said nucleosides are joined together by internucleoside linkages such that the base portion of said nucleosides form a mixed base sequence; at least one of said nucleosides includes a modified ribofuranosyl moiety bearing a 2'-fluoro substituent; provided that at least two of said nucleosides are 2-fluoro modified ribofuranosyl nucleosides when said internucleoside linkages are phosphodiester linkages.
Claim 3
Dependent Claim
12 words
The compound of claim 1 having 5 to 50 nucleoside linked nucleosides.
Claim 4
Dependent Claim
24 words
The compound of claim 1 wherein at least two of said nucleosides are covalently bound through phosphorothioate, methyl phosphonate, or phosphate alkylate internucleoside linkages.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-12-20 | 2003-06-21 | 2003-12-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-12-20 | 2007-06-21 | 2007-12-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-12-20 | 2011-06-21 | 2011-12-21 | $7700.00 | Window Closed / Lapsed |