US4381344A
Expired / Lapsed
US
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Process for producing deoxyribosides using bacterial phosphorylase
Assignee: SmithKline Beecham Corp
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Filing: 1980-04-25
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Granted: 1983-04-26
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Expires: 2000-04-25
Abstract
Abstract The novel compounds 3-deaza-2'-deoxyadenosine and certain of its derivatives and their pharmaceutically acceptable salts have anti-inflammatory activity as well as immune response suppression activity. 3-Deaza-2'-deoxyadenosine and certain of its intermediates are synthesized by the enzyme catalyzed reaction of the appropriately substituted 3-deazapurine with a 2'-deoxyribose donor.
Inventors
- 👤 Janet L. Rideout
- 👤 Thomas A. Krenitsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:55
CPC Classifications
C; C12; C12P; C12P19/00; C12P19/26; C12P19/28; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/052
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
51 words
A process for producing compounds of formula (II) ##STR8## wherein R is halogen, amino or substituted amino including protected amino which process comprises reacting a 4-substituted-1H-imidazo-[4,5-c]-pyridine base of formula (III) ##STR9## wherein R is as hereinbefore defined with a 2-deoxyribosyl donor system comprising 2-deoxyribose-1-phosphate and a bacterial purine nucleoside phosphorylase enzyme.
Claim 2
Dependent Claim
51 words
A process for producing compounds of formula (II) ##STR8## wherein R is halogen, amino or substituted amino including protected amino which process comprises reacting a 4-substituted-1H-imidazo-[4,5-c]-pyridine base of formula (III) ##STR9## wherein R is as hereinbefore defined with a 2-deoxyribosyl donor system comprising 2-deoxyribose-1-phosphate and a bacterial purine nucleoside phosphorylase enzyme.
Claim 3
Dependent Claim
20 words
A process according to claim 1 wherein 2-deoxyribose-1-phosphate is generated enzymatically in situ from a 2-deoxyribosyl donor and inorganic phosphate.
Claim 4
Dependent Claim
24 words
A process according to claim 2 wherein 2-deoxyribose-1-phosphate is generated from a pyrimidine-2'-deoxyriboside and inorganic phosphate in the presence of a pyrimidine nucleoside phosphorylase.
Claim 5
Dependent Claim
13 words
The method of claim 1, 2 or 3 in which R is amino.
Claim 6
Independent Claim
27 words
The method of preparing the compound 4-amino-1-(2-deoxy-β-D-ribofuranosyl)-1H-imidazo-[4,5-c]-pyridine which comprises reacting a compound of the formula ##STR10## with 2-deoxyriboside-1-phosphate in the presence of bacterial purine nucleoside phosphorylase enzyme.
Claim 7
Independent Claim
27 words
The method of preparing the compound 4-amino-1-(2-deoxy-β-D-ribofuranosyl)-1H-imidazo-[4,5-c]-pyridine which comprises reacting a compound of the formula ##STR10## with 2-deoxyriboside-1-phosphate in the presence of bacterial purine nucleoside phosphorylase enzyme.
References Cited (Backward Citations)
US3269917A
Cited
US3976545A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-04-25 | 1986-10-25 | 1987-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-04-25 | 1990-10-25 | 1991-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-04-25 | 1994-10-25 | 1995-04-26 | $7700.00 | Window Closed / Lapsed |