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US3976545A
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1,2,4-Triazol E-3-carboxamides as antiviral agents
Assignee: Viratek Inc
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Filing: 1975-09-29
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Granted: 1976-08-24
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Expires: 1995-09-29
Abstract
Abstract The use of 1,2,4-triazole-3-carboxamide and 1,2,4-triazole-3-thiocarboxamide and physiologically compatible salts thereof as antiviral agents is disclosed. A process for synthesizing 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide is also disclosed.
Inventors
- 👤 Joseph T. Witkowski
- 👤 Roland K. Robins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:29
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/056; C12; C12P; C12P19/00; C12P19/26; C12P19/28; C12P19/38
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
40 words
A process of preparing 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide in which 1,2,4-triazole-3-carboxamide is reacted with the enzyme nucleoside phosphorylase in the presence of ribose-1-phosphate at a pH of from about 5 to about 9 and a temperature of from about 0° to about 50°C.
Claim 2
Dependent Claim
40 words
A process of preparing 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide in which 1,2,4-triazole-3-carboxamide is reacted with the enzyme nucleoside phosphorylase in the presence of ribose-1-phosphate at a pH of from about 5 to about 9 and a temperature of from about 0° to about 50°C.
Claim 3
Dependent Claim
20 words
The process of claim 1 in which said enzyme is utilized a concentration of about 0.015 to about 0.75 mg/ml.
Claim 4
Dependent Claim
36 words
The process of claim 2 in which the triazole-3-carboxamide is utilized in a concentration of at least about 5×10 - .sup. 5 M and said ribose-1-phosphate at a concentration of at least about 2×10.sup. -5 M.
Claim 5
Dependent Claim
24 words
The process of claim 2 in which the pH is about 7 to about 8 and the temperature from about 25° to about 35°C.
Claim 6
Dependent Claim
16 words
The process of claim 4 in which the concentration of said enzyme is about 0.15 mg/ml.
References Cited (Backward Citations)
US3535207A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-24 | 1980-02-23 | 1980-08-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-24 | 1984-02-23 | 1984-08-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-24 | 1988-02-23 | 1988-08-24 | $7700.00 | Window Closed / Lapsed |